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Ziprasidone
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ziprasidone hcl moa

Patient education about ziprasidone that has been reviewed by a physician - includes a description, dosage information, and instructions.

Other names for this medication:
Geodon, Zeldox

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Sertraline, Bupropion, Buspirone, Bupron, Fluoxetine, Clomipramine, Zoloft, Trazodone, Tofranil, Aripiprazole, Lexapro, Oxetin, Clofranil, Citalopram, Seroquel, Strattera

Description

Patient's taking ziprasidone will likely experience a lower incidence of orthostatic hypotension, cognitive disturbance, sedation, weight gain, and disruption in prolactin levels since ziprasidone has a lower affinity for histamine H1, muscarinic M1, and alpha1-adrenoceptors. Due to ziprasidone's preference and affinity for particular receptors, its effects can be distinguished from those of other antispychotics. Similar to other atypical antipsychotics, ziprasidone binds to serotonin-2A (5-HT2A) and dopamine D2 receptors. However, ziprasidone differs from other antipsychotics like olanzapine, quetiapine, risperidone, and aripiprazole in that it has a higher 5-HT2A/D2 receptor affinity ratio. Ziprasidone's moderate ability to bind to norepinephrine and serotonin reuptake sites may be a factor in its antidepressant and anxiolytic activity. Due to ziprasidone's powerful interaction with 5-HT2C, 5-HT1D, and 5-HT1A receptors in brain tissue, it has the ability to significantly improve mood regulation, significantly relieve negative symptoms, improve overall cognitive function, and reduce motor dysfunction.

Dosage

Intramuscular administration for the short-term treatment of schizophrenia-related agitation: 10–20 mg, with a daily maximum of 40 mg. Start with 40 mg twice daily for the acute management of manic/mixed episodes of bipolar I disorder. The recommended dosage can be changed up to 80 mg twice daily. Dose adjustments ought to be spaced no less than two days apart. Every 2 hours, 10 mg doses can be given. Doses of 20 mg may be administered every 4 hours Your doctor will determine the best dose for you. Follow the directions on your prescription label carefully. On the second day of treatment, up the dosage to 60 or 80 mg twice daily. Continue treatment at the same dosage at which the patient was initially stabilized, which is between 40 and 80 mg twice daily, as a maintenance treatment for bipolar I disorder as an adjunct to lithium or valproate. Oral/Injectable: The following is a list of suggested dosages: Schizophrenia: Start at 20 mg twice daily. In doses as high as 100 mg twice daily, safety and effectiveness have been proven. Within the range of 40-80 mg twice daily, subsequent dose adjustments should be based on tolerability and efficacy. As directed, take ziprasidone as soon as possible. Use the smallest effective dose possible.

Missed dose

To make up for a missed dose, do not take a second one. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. As soon as you remember, take the missed dose.

Overdose

Get immediate medical help or dial 1-800-222-1222 for poison help.

Storage

Keep below 30°C temperature, away from light & moisture. Place away from children's reach.

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Side effects

If you experience any strange side effects while taking this medication, contact your doctor right away. The Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program is available online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you or your doctor notice a serious side effect. Call your doctor right away or seek emergency medical attention if you experience any of the following symptoms, those mentioned in the IMPORTANT WARNING section, or those in the SPECIAL PRECAUTIONS section: headache, restlessness, anxiety, lack of energy, constipation, diarrhea, loss of appetite, muscle pain, stomach pain, runny nose, cough, weight gain, breast enlargement or discharge, late or missed menstrual period, decreased sexual ability, dizziness, feeling unsteady, or trouble Tell your doctor if any of these symptoms are severe or do not go away: headache restlessness anxiety lack of energy constipation diarrhea loss of appetite muscle pain stomach pain runny nose cough weight gain breast enlargement or discharge late or missed menstrual period decreased sexual ability dizziness, feeling unsteady, or having trouble keeping your balance unusual movements of your face or body that you cannot control fast, irregular, or pounding heartbeat rash or hives itching blisters or peeling of skin mouth sores swollen glands fever chills shaking muscle stiffness falling confusion sweating loss of consciousness painful erection of the penis that lasts for hours Some side effects can be serious. There could be negative effects from ziprasidone.

Interactions

Skip the alcohol. Consume with food.

Contraindications

Age-Related Dementia-Related Psychosis in Elderly Patients: Increased Incidence of Cerebrovascular Adverse Reactions (e.g., Stroke, Transient Ischemic Attack). It is possible to die from DRESS and other severe cutaneous adverse reactions (SCAR). If DRESS or SCAR is suspected, stop taking ziprasidone. Dyslipidemia: Unwanted changes have been seen in patients taking atypical antipsychotic medications. Monitoring for polydipsia, polyuria, polyphagia, and weakness are signs of hyperglycemia and Diabetes Mellitus (DM). Antipsychotic medications have been linked to leukopenia, neutropenia, and agranulocytosis. Manage by stopping the drug as soon as possible and keeping a close eye on things. Metabolic Modifications: Atypical antipsychotics have been linked to metabolic modifications that could raise the risk of cardiovascular and cerebral vascular disease. Keep track of weight gain. Antipsychotic drugs have been associated with the potentially fatal neuroleptic malignant syndrome (NMS), a symptom complex. Patients with known cardiovascular or cerebral vascular disease should use orthostatic hypotension with caution. Blood glucose levels should be monitored in patients with DM risk factors both before and after treatment. Patients with a pre existing low white blood cell count (WBC) or a history of leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and should discontinue ziprasidone at the first sign of a decline in WBC in the absence of other causative factors. Potential for Cognitive and Motor impairment: Patients should use caution when operating machinery. QT Interval Prolongation: Use of ziprasidone should be avoided in patients who have bradycardia, hypokalemia, hypomagnesemia, congenital prolongation of the QT interval, or when combined with other medications that have shown to prolong the QT interval. Patients should stop treatment if they experience a rash that has no known cause. Use this medication with caution in patients who have a history of seizures or who have medical conditions that lower their seizure threshold. Ziprasidone exposure has been associated with serious skin side effects, including Stevens-Johnson syndrome and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Suicide: Closely watch over high-risk patients. Tardive Dyskinesia: May develop acutely or chronically. These metabolic alterations also cause weight gain, hyperglycemia, and dyslipidemia. Weight Gain: Weight gain has been reported.

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Testimonials
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user3035398 Jun 21, 2015, 8:25:06 PM

If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or the SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment: Unusual movements of your face or body that you cannot control Rash Hives Itching Blisters or peeling of skin Mouth sores Swollen glands Fever Chills Yellowing of the skin or eyes Shortness of breath Fast, irregular, or pounding heartbeat Shaking Muscle stiffness Falling Confusion Sweating Loss of consciousness Painful erection of the penis that lasts for hours Ziprasidone injection may cause other side effects. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Call your doctor if you have any unusual problems while receiving this medication. Tell your doctor if any of these symptoms are severe or do not go away: Headache Injection site pain Nausea Vomiting Restlessness Heartburn Anxiety Agitation Lack of energy Constipation Diarrhea Loss of appetite Weight gain Stomach pain Pricking, or tingling feeling Speech problems Breast enlargement or discharge Late or missed menstrual period Decreased sexual ability Dizziness, feeling unsteady, or having trouble keeping your balance Some side effects can be serious.

McShaman Nov 10, 2021, 3:50:15 AM

Lurasidone, sold under the trade name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder. The drug also has negligible affinity for the histamine H receptor and the muscarinic acetylcholine receptors, and hence has no antihistamine or anticholinergic effects. Lurasidone is chemically similar to perospirone (also a chemical analogue of ziprasidone), as well as risperidone, paliperidone and iloperidone. The drug has a relatively well tolerated side effect profile, with low propensity for QTc interval changes, weight gain and lipid-related adverse effects. Lurasidone is mainly metabolized in the liver via the enzyme CYP3A4, but has negligible affinity to other cytochrome P450 enzymes.

user261141 Aug 18, 2018, 6:13:24 PM

(5aR,8aS)-3-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-5,5a,6,7,8,8a-hexahydrocyclopenta[3,4]pyrrolo[2,1-c][1,2,4]triazole FC(F)(F)c1cc(ccc1)N5CCN(CCc4nnc2n4C[[email protected]@H]3CCC[[email protected]]23)CC5 Lorpiprazole (INN) (brand name Normarex) is a marketed anxiolytic drug of the phenylpiperazine group. It has been described as a serotonin antagonist and reuptake inhibitor (SARI) in the same group as trazodone, nefazodone, and etoperidone.

Gerilyn Gruzwalski Jul 16, 2012, 7:25:33 AM

Although there is no clear link between ziprasidone and diabetes, patients should be tested during treatment for elevated blood-sugars. Ziprasidone frequently causes tiredness (1 in 7 patients). There is a slight risk (1 in 1500 patients) that ziprasidone by itself could significantly increase the QT interval. Therefore, care should be exercised in any activity requiring mental alertness, such as operating a motor vehicle (including automobiles) or operating hazardous machinery. A potentially fatal complex referred to as neuroleptic malignant syndrome (NMS) has been reported with other anti-psychotic drugs.

Oculus Dexter May 31, 2016, 4:31:04 PM

Since pramocaine exhibited approximately dose proportional pharmacokinetics following sc administration, the absolute bioavailability characteristics of Vagisil medicated wipes 50 mg orally or 200 mg dose is nothing expected to be similar subjects to the 100 mg sublingual dose. Comments bedaquiline may greatly decrease the sedative activities each of ziprasidone. New hormone free Sunmark milk molars of magnesia mint contraceptive gel which contains no magnesium hydroxide, the most effective contraceptive methods available without a prescription.

user398843 Oct 21, 2021, 1:26:53 PM

Online accounts and anecdotal reports state that the drug can give users a feeling much like what is experienced with marijuana. Tell your doctor if you have any of the following symptoms: This medicine might also cause dizziness or fainting if you get up too quickly from a lying position. Use caution and drink plenty of fluids if you're exposed to hot weather or if you plan to exercise.

M Jayaprabu Mar 31, 2014, 6:39:12 PM

Ziprasidone is effective in the treatment of schizophrenia, though evidence from the CATIE trials suggests it is less effective than olanzapine, and equally as effective compared to quetiapine. Less commonly there may be a feeling of the world spinning, numbness, or muscle pains. Ziprasidone is known to trigger mania in some bipolar patients.

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