Description
Blood flow into the corpus cavernosum is increased and smooth muscles are relaxed as a result of cyclic GMP. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. By increasing the amount of cGMP, vardenafil's inhibition of phosphodiesterase type 5 (PDE5) improves erectile function. Nitric oxide (NO), which is released by nerve terminals and endothelial cells and stimulates the synthesis of cGMP in smooth muscle cells, is the mediator of this response. Vardenafil prevents phosphodiesterase type 5 (PDE5), a specific cGMP phosphodiesterase, from degrading cGMP in the corpus cavernosum, a region surrounding the penis, which is the site of erection.
Dosage
The moment you take the tablet out of the blister package, put it on your tongue, and then close your mouth. Ask your pharmacist if you have any questions about the type of vardenafil you were given. Make sure you only take the brand of vardenafil your doctor prescribed. Never take it in larger or smaller amounts or more frequently than your doctor has instructed. The rapidly disintegrating tablet should not be taken with liquids, including water. Never attempt to force the tablet through the foil. Do not use any of the medication from the pack if any of the blisters are torn, broken, or do not contain tablets. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. To remove the tablet from the blister package, follow the instructions on the packaging. Prior to taking your first dose, inspect the blister pack if you are using a rapidly disintegrating tablet. The rapidly disintegrating tablets are only offered in one strength, so your doctor won't be able to change your dosage if you're taking them. Your doctor might advise taking vardenafil less frequently if you have specific medical conditions or are taking specific medications. Your doctor might recommend the regular tablets if you require a higher or lower dosage. 60 minutes prior to sexual activity, it is typically taken as needed, with or without food. Follow the manufacturer's instructions when taking vardenafil. Talk to your doctor about eating grapefruit or drinking grapefruit juice while taking this medicine. If vardenafil is not working as intended or if any side effects occur, let your doctor know right away. The tablet will dissolve very quickly. Inquire with your doctor or pharmacist for more details if you believe this medication may be prescribed for other purposes. Vardenafil can be taken orally as a tablet and a rapidly disintegrating tablet, which dissolves in the mouth and can be swallowed without water. It is not possible to use vardenafil tablets in place of vardenafil rapidly disintegrating tablets. Typically, taking Vardenafil only once every 24 hours is recommended. Your doctor will likely start you off on a typical dose of vardenafil tablets and then adjust it based on how you respond to the drug.
Missed dose
You should wait 24 hours between doses. Vardenafil should not be taken more than once daily. You probably aren't on a dosing schedule because vardenafil is taken as needed.
Overdose
Call your doctor or the nearest Poison Control Center right away if you take more vardenafil than is recommended, or get emergency medical help.
Storage
This medication should not, however, be flushed down the toilet. A medicine take-back program is the preferable method for getting rid of your medication. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Store this medication out of children's reach in the tightly closed, original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature and away from excess heat and moisture (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and put medications in a secure location right away that is up and away and out of young children's sight and reach to prevent poisoning. http://www.upandaway.org Unneeded medications should be disposed of in a specific manner to prevent pets, kids, and other people from eating them.
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There is no relevant indication for use of Vardenafil Accord in children. In patients with severe renal impairment (creatinine clearance <30 mL/min), a starting dose of 5 mg should be considered. The recommended dose is 10 mg taken as needed approximately 25 to 60 minutes before sexual activity. The maximum dose recommended in patients with moderate hepatic impairment (Child-Pugh B) is 10 mg (see sections 4.3 and 5.2). A starting dose of 5 mg should be considered in patients with mild and moderate hepatic impairment (Child-Pugh A-B).
Talk to your doctor before taking Valif 20 mg if you have heart trouble, as it may be risky for you to have sex. Concomitant use of Lofatra and vasodilators, two drug classes, can cause a significant drop in blood pressure. Inform your doctor if you are suffering from irregular heartbeat, a physical condition affecting the shape of a penis, priapism, stomach ulcers, bleeding disorders, or using any other treatments for erection difficulties. This vardenafil formulation is not for use by children or adolescents under 18 years. Caution is advised when a PDE5 inhibitor is co-administered with alpha-blockers.
This drug does not provide orgasm or increase your sexual performance. This drug is sold under the name Levitra in doses such as 10 mg, 20 mg, 40 mg, and 60 mg. Generic versions of this drug include Vilitra, Zhewitra, Snovitra, etc. For best results, consume the drug on an empty stomach and exactly 1 hour before sexual intercourse.
However, an increase to a maximum 20 mg dose should be carefully considered depending on the individual tolerability (see sections 4.4 and 4.8). In patients with severe renal impairment (creatinine clearance <30 ml/min), a starting dose of 5 mg should be considered. Based on tolerability and efficacy, the dose may subsequently be increased.
The potential exists for adverse drug interactions with drugs which inhibit or induce CYP3A4 and anti-hypertensive drugs due to their capacity to diminish blood pressure. Co-administration of sildenafil with ritonavir is not advised and in any event the maximum dose of sildenafil should under no circumstances exceed 25mg within 48 hours. Sildenafil, vardenafil and tadalafil are primarily metabolised by hepatic enzymes via cytochrome CYP3A4 with some contribution from isoform CYP2C9 for sildenafil and from CYP3A5 and CYP2C for vardenafil. {openx:269} CYP3A4 inhibitors Sildenafil: When sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25mg should be considered.
Substances that exert stimulating, hallucinating, or psychoactive effects, or the ones containing nitrates such as weed, may cause critical side effects. Priapism or a painful erection that stays for more than 4 hours. No more than one tablet should be consumed within 24 hours.