Trihexyphenidyl patient information, including a description, dosage, and administration guidelines, has been reviewed by a physician.
The mechanism by which the anticholinergic works to treat the symptoms of Parkinson's disease or other movement disorders has not yet been fully understood. Trihexyphenidyl has been shown to have a higher affinity for central muscarinic receptors in the cerebral cortex than for peripheral ones in in vivo studies. Other research suggests that trihexyphenidyl may alter nicotinic acetylcholine receptor neurotransmission, which would indirectly increase dopamine release in the striatum. A non-selective antagonist of muscarinic acetylcholine receptors, trihexyphenidyl has a higher affinity for the M1 subtype.
-After symptoms have been controlled for several days, it may be possible to reduce the dose of discontinue use; there are reports of EPS remaining in remission for long periods after this drug has been discontinued. -The patient's needs should be taken into consideration when deciding whether to give a dose before or after meals; this medication does cause dry mouth, so taking it before meals might be advantageous unless it also causes nausea. -Divided doses of the daily dose may improve tolerance; dosages higher than 10 mg/day should be divided and administered four times daily. Specific dosage instructions for trihexyphenidyl Initial dose: 1 mg orally once a day -Titrate in 2 mg/day increments every 3 to 5 days Maintenance dose: 6 to 10 mg orally in divided doses Maximum dose: Some patients, particularly those with postencephalitic parkinsonism, may require 12 to 15 mg/day Concomitant Use with Levodopa: 3 to 6 mg orally per day in divided doses -When used concomitantly with levodopa, the dose of both drugs may need to be reduced -Adjust doses based on side effects and symptom control Comments: -Doses should be individualized; start low and increase slowly, especially in elderly patients. Initial dose: 1 mg orally once; if symptoms are not under control within a few hours, additional doses should be given until a satisfactory level of control is reached Maintenance dose: 5 to 15 mg/day orally in divided doses; although some patients may benefit from 1 mg/day Comments: -Control of extrapyramidal symptoms (EPS) may be more quickly attained by temporarily lowering the dose of the responsible agent. Use: As a supplement to other treatments for all types of Parkinson's disease. Use: For the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones. Usual Adult Dose for Extrapyramidal Reaction: Usual Adult Dose for Parkinson's Disease:
Do not take a double dose to make up for a missed one. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. When you remember, immediately take the missed dose.
The signs of an overdose can include extreme drowsiness, fever, dilated pupils, feeling hot, paleness in the face, dry mouth, hallucinations, paranoia, agitation, seizure, or numbness in or near the mouth, nose, or throat. Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room.
You shouldn't flush this medication down the toilet, though. Instead, utilizing a medicine take-back program is the best way to get rid of your medication. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. For information on take-back programs in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.
For more information, consult your physician or pharmacist. For medical advice about side effects, contact your doctor. Trihexyphenidyl's typical side effects include dry mouth, blurred vision, dizziness, mild nausea, or jitteriness. See the "Drug Precautions" section. Trihexyphenidyl has been associated with severe side effects. Tell your doctor if you have any side effect that bothers you or that does not go away. Trihexyphenidyl's side effects are not all listed here. Call 1-800-FDA-1088 to report side effects to the FDA.
Before taking an opioid, a sleeping aid, a muscle relaxant, or a medication for seizures or anxiety, consult your doctor. More info on trihexyphenidyl Pregnancy & breastfeeding safety dosage information Reviews (20) Drug images Pricing & coupons Spanish Drug class: anticholinergic antiparkinson agents Patient resources Advanced Reading Trihexyphenidyl Tablets Trihexyphenidyl Oral Solution Other brands Artane, Trihexane Professional resources Prescribing Information Related treatment guides Parkinson's disease Cerebral Spasticity Extrapyramidal Reaction This list does not include all possible drug interactions. Trihexyphenidyl may interact with other medications, including prescription and OTC drugs, vitamins, and herbal remedies. Inform your doctor of all other medications you are taking, especially: This list is not complete. Drug interactions with trichyphenidyl (more information) This effect can be exacerbated if trihexyphenidyl is taken with other sedative medications. medications for colds or allergies (Benadryl and similar products), additional Parkinson's disease medications, medications for nausea, motion sickness, or irritable bowel syndrome, medications for an overactive bladder, or bronchodilator asthma medications.
Inform your doctor and pharmacist about all prescription and non-prescription drugs, vitamins, dietary supplements, and herbal products you are currently taking or plan to take. Be sure to mention any of the following: tranquilizers. tell your doctor if you have or have ever had glaucoma, high blood pressure, problems with your urinary system or prostate, stomach problems, or heart, kidney, or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Inform your doctor and pharmacist if you have any allergies before taking trihexyphenidyl, whether they are to the drug, any other medications, or any of the ingredients in the preparation. Talk to your doctor about the advantages and disadvantages of taking trihexyphenidyl if you are 65 years of age or older. If you become pregnant while taking trihexyphenidyl, call your doctor. If you are having surgery, including dental surgery, let the doctor or dentist know that you are taking trihexyphenidyl. Trihexyphenidyl is typically not recommended for older adults to take because it is less reliable and less efficient than other drugs that can be used to treat the same condition.
Can trihexyphenidyl get you high?
Anxiety, nervousness, confusion, and agitation occurred in patients who were on higher doses. Trihexyphenidyl also produces a short-acting euphoric and mood-elevating effect, which is why it is a drug of potential misuse. There have been cases of the disruption of normal sleep architecture (REM sleep depression).
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