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Tolterodine
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tolterodine dose

Both urine leakage and the need to urinate frequently are reduced. It works by relaxing the bladder muscle. Tolterodine is prescribed for overactive bladder.

Other names for this medication:
Detrol, Detrusitol

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Description

The 5-hydroxymethyl derivative, a key pharmacologically active metabolite, is created by the liver's metabolism of tolterodine following oral administration. Since neither tolterodine nor its 5-hydroxymethyl metabolite exhibits much activity or affinity for other neurotransmitter receptors or other potential cellular targets like calcium channels, they are highly specific for muscarinic receptors. Cholinergic muscarinic receptors are the mediators of both salivation and urinary bladder contraction. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. The primary effects of tolterodine are an increase in residual urine, which indicates an incomplete bladder emptying, and a decrease in detrusor pressure, which is consistent with an antimuscarinic action on the lower urinary tract. A significant impact of tolterodine is seen on bladder operation. Tolterodine is a competitive muscarinic receptor antagonist.

Dosage

Take it only as directed by your doctor, neither more nor less than that amount or more frequently. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Do not split, chew, or crush the extended-release capsules; instead, swallow them whole. Exactly as prescribed, take tolterodine. The extended-release capsule is typically taken once daily with liquids. Usually, two daily doses of the tablet are taken. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Tolterodine comes in oral tablet and extended-release (long-acting) capsule forms.

Missed dose

Do not use 2 doses in one day If you miss a dose, skip it and take your next dose at the scheduled time.

Overdose

However, seek immediate medical attention if overdose is thought to have occurred. If tolterodine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. Call your doctor or the local Poison Control Center if you take too much tolterodine, or go to the hospital right away for emergency care.

Storage

You should not, however, dispose of this medication in the toilet. A medicine take-back program is the preferable method for getting rid of your medication. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Store this medication out of children's reach in the tightly closed, original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more information. Keep it at room temperature and out of the bathroom and away from light, excessive heat, and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

If you experience any of the following symptoms, stop taking tolterodine and contact your doctor right away. You should also seek emergency medical attention if necessary. Dry mouth, heartburn, headache, constipation, diarrhea, dry eyes, dry skin, joint pain, excessive fatigue, difficulty emptying the bladder painfully, weight gain, anxiety, swelling of the face, throat, tongue, lips, and eyes, as well as difficulty swallowing or breathing. Inform your doctor if any of these symptoms persist or are particularly bothersome: dry mouth, heartburn, headache, constipation, diarrhea, dry eyes, dry skin, joint pain, excessive fatigue, painful urination, weight gain, anxiety, swelling of the face, throat, tongue, lips, and eyes, and difficulty swallowing or breathing. Some side effects can be very serious. There may be negative effects from tolterodine.

Interactions

For more details, consult your physician or pharmacist. Tell your doctor right away if you take any of the following medications in addition to tolterodine: clarithromycin, cyclosporin, erythromycin, itraconazole, ketoconazole, miconazole, vinblastine. If you take tolterodine with other medicines, the effects of either could be increased, decreased, or altered. Inform your doctor of all the drugs you are taking or intend to take, including vitamins, herbal supplements, prescription and non-prescription medications.

Contraindications

Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. If you use any of the following medications, make sure to mention them: amiodarone (Nexterone, Pacerone); antihistamines; atazanavir (Reyataz, in Evotaz); clarithromycin; cyclosporine (Gengraf, Neoral, Sandimmune); donepezil (Aricept, in Namzaric); erythromycin (E.E.S., Ery-Tab, others); galant Inform your doctor and pharmacist if you have any allergies before taking tolterodine, including those to other medicines, tolterodine, fesoterodine fumarate (Toviaz), or any of the ingredients in tolterodine tablets or extended-release capsules. Before you know how this medication affects you, do not operate machinery or drive a car. Tolterodine may cause you to feel drowsy or woozy, or it may cause blurred vision or other vision problems. If you become pregnant while taking tolterodine, call your doctor. Tolsura; drugs for irritable bowel syndrome, motion sickness, or Parkinson's disease; ketoconazole; procainamide; quinidine (in Nuedexta); ritonavir (Norvir, in Kaletra, Technivie, Viekira); rivastigmine (Exelon); saquinavir (Invirase); sotalol (Betapace, Sorine, Sotylize); and Tell your doctor if you have or have ever had glaucoma (increased pressure in the eyes that may cause vision loss), urinary retention (inability to empty your bladder completely or at all), or gastric retention (slow emptying of your stomach). Your doctor may advise against taking tolterodine.

What is the best time of day to take tolterodine?

Dosage for tolterodine tablets Adults will usually take 2mg in the morning and 2mg in the evening. Leave a gap of 12 hours between doses. Children will usually take between 1mg and 4mg a day. If you are giving tolterodine to a child to stop bedwetting, the usual dose is 1mg taken at bedtime.

What class of drug is tolterodine and how does it work?

Tolterodine is a type of medicine called an antimuscarinic (or anticholinergic) muscle relaxant. It works by relaxing the muscle that is found in the wall of the bladder. This helps to increase the volume of pee your bladder can hold and control the release of pee.

Can I stop taking it?

If you want to stop taking tolterodine, talk to your doctor first. If you've been taking it for at least 6 months, your doctor may suggest at your review that you can stop taking it for up to 4 weeks to see how your symptoms change without it. Some people find that the improvement in their symptoms continues after they've stopped taking the medicine.

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Testimonials
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user242587 Aug 22, 2012, 7:24:55 AM

Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). erythromycin and clarithromycin), antifungal agents (e.g. Concomitant medication with other drugs that possess antimuscarinic properties may result in more pronounced therapeutic effect and side-effects. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4).

bandris Sep 27, 2013, 11:14:45 PM

Absorption Distribution Metabolism Extensively hepatic, primarily via CYP2D6 to 5-hydroxymethyltolterodine (active) and 3A4 usually (minor pathway). Excretion Urine (77%); feces (17%); primarily as metabolites (<1% unchanged drug) of which the active 5-hydroxymethyl metabolite accounts for 5% to 14% (<1% in poor metabolizers); as unchanged drug (<1%; <2.5% in poor metabolizers) Time to Peak Immediate release tablet: 1-2 hours; Extended release capsule: 2-6 hours Half-Life Elimination Immediate release tablet: Extensive metabolizers: ~2 hours; Poor metabolizers: ~10 hours Extended release capsule: Extensive metabolizers: ~7 hours; Poor metabolizers: ~18 hours Protein Binding In patients with a genetic deficiency of CYP2D6, metabolism via 3A4 predominates.

Koidi Simmons Jul 23, 2020, 3:44:40 PM

ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4). Concomitant medication with other drugs that possess antimuscarinic properties may result in more pronounced therapeutic effect and side-effects. Concomitant treatment with fluoxetine (a potent CYP2D6 inhibitor) does not result in a clinically significant interaction since tolterodine and its CYP2D6-dependent metabolite, 5-hydroxymethyl tolterodine are equipotent. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). Conversely, the therapeutic effect of tolterodine may be reduced by concomitant administration of muscarinic cholinergic receptor agonists.

Neo Steed Jun 7, 2018, 2:54:37 AM

Conversely, the therapeutic effect of tolterodine may be reduced by concomitant administration of muscarinic cholinergic receptor agonists. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). A clinical study has indicated that tolterodine is not a metabolic inhibitor of CYP2D6, 2C19, 2C9, 3A4 or 1A2.

gOnZo Jul 27, 2017, 4:30:46 AM

Conversely, the therapeutic effect of tolterodine may be reduced by concomitant administration of muscarinic cholinergic receptor agonists. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). A clinical study has indicated that tolterodine is not a metabolic inhibitor of CYP2D6, 2C19, 2C9, 3A4 or 1A2. erythromycin and clarithromycin), antifungal agents (e.g. Concomitant systemic medication with potent CYP3A4 inhibitors such as macrolide antibiotics (e.g.

abricos01 Jun 30, 2020, 5:34:58 PM

The drug, Terol is present in the tablet form. Terol LA- 4 mg consists of active ingredient Tolterodine tartrate. Buy Terol LA- 4 mg online to treat your overactive bladder syndrome.

adizere Feb 19, 2013, 12:35:49 AM

• After three months of treatment with mirabegron 50mg daily, the number of urinations was reduced by an average of 1.8 per day, compared with a reduction of 1.2 per day for placebo. The co-primary efficacy endpoints were reduction from baseline to final visit in mean number of micturitions and mean number of incontinence episodes per day. • Mirabegron produced similar reductions to tolterodine in the mean number of micturitions and episodes of incontinence per day from the first measured time point (one month) until study end. The incidence and severity of adverse events were logged over 12 months.

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