Tofranil dosage, description, and administration information has been reviewed by a physician.
Other names for this medication:
Tofranil should not be taken in two doses at once. Skip the missed dose and take your next dose at the scheduled time if it is almost time for your next dose. Take the missed dose right away if you forget to do so. As directed, take Tofranil as directed. Tofranil comes in tablet form, and depending on your doctor's instructions, you may need to take it once, twice, or more throughout the day. Tofranil tablets are typically taken an hour prior to bedtime, or as one dose in the afternoon and another dose at bedtime, to prevent bedwetting in children.
Carefully adhere to the instructions on the prescription label. Take this medication exactly as prescribed by your doctor. The recommended dose range for Tofranil (imipramine) for the treatment of depression is 75 mg–300 mg/day. Your doctor may recommend a different dose based on the following factors: the condition being treated, other medical conditions you have, other medications you are taking, how you respond to this medication, your age, and your weight. For the treatment of childhood enuresis in children younger than 12 years old, a dose range of 25 mg to 50 mg/day of Tofranil (imipramine) is advised. For the treatment of childhood enuresis in children over the age of 12, the dosage range for Tofranil (imipramine) is 25 mg–75 mg/day.
Do not increase the dose to make up lost time. Skip the missed dose if the time for the subsequent dose is approaching. If you forget to take a dose, do so right away. At the scheduled time, take your subsequent dose.
Call your physician or the local Poison Control Center right away if you take too much Tofranil, or go to the hospital right away if you need emergency care.
Consult your pharmacist or the neighborhood waste management business. Unless specifically instructed to do so, avoid flushing or pouring medications down the drain. Keep out of the bathroom. Pets and children should not have access to any medications. Properly discard this product when it is expired or no longer needed. Store at room temperature away from light and moisture.
Rarely will this medication cause a very serious allergic reaction. It is possible to experience dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain or loss, and increased perspiration. If any of the following symptoms appear in you: rapid heartbeat, hallucinations, loss of coordination, extreme nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness, or severe dizziness, seek medical attention right away. If you experience any very serious side effects, such as chest pain, a slow, fast, or irregular heartbeat, fainting, seizures, difficulty speaking, weakness on one side of the body, eye pain, swelling, or redness, dilated pupils, or vision changes (such as seeing rainbows around lights at night), seek immediate medical attention. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Inform your doctor or pharmacist as soon as possible if any of these effects persist or get worse. Contact your doctor or pharmacist if you experience any additional effects that aren't covered above. For medical advice about side effects in Canada, contact your doctor. Call your doctor in the US for medical advice regarding side effects. Many people using this medication do not have serious side effects. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. See also the Warning section. Inform your physician right away if you experience any severe side effects, such as mental/mood changes (such as confusion, depression, memory issues), enlarged/painful breasts, unusual breast milk production, irregular/painful menstrual cycles, muscle stiffness, restlessness, ringing in the ears, sexual problems (such as decreased sexual ability, changes in desire), shakiness (tremors), numbness/tingling of the hands/feet, pain/redness Tell your doctor or pharmacist about all the medications you take (see the Drug Interactions section) because the risk increases if you also take other medications that raise serotonin. Possible side effects are not covered in this list in full. Serotonin syndrome/toxicity, a very serious condition, is a rare but potentially fatal side effect of this medication. You can contact the FDA to report side effects at 1-800-FDA-1088 or online at www.fda.gov/medwatch. Call 1-866-234-2345 to report side effects to Health Canada.
Ask your doctor when to start or stop taking this medication. Ask your pharmacist about the safe use of those products. When using this drug in conjunction with MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), consult your doctor before taking any of these drugs. Before taking imipramine, let your doctor or pharmacist know about all other medications you are taking. All of your medications, including those for colds and coughs, should have their labels read carefully because they may contain decongestants or ingredients that make you drowsy and could raise your blood pressure or heart rate. The blood levels of this medication drop when you smoke cigarettes. Without your doctor's permission, you should never start, stop, or modify the dosage of any medications. When using imipramine, avoid taking drugs that contain desipramine. Interactions between drugs can alter how well your medications work or put you at risk for serious side effects. Examples include barbiturates (such as phenobarbital), cimetidine, haloperidol, certain drugs for heart rhythm (such as flecainide, propafenone), halofantrine, certain HIV protease inhibitors (such as fosamprenavir), phenothiazines (such as thioridazine), pimozide, certain anti-seizure drugs (such as phenytoin), terbinafine, trazodone, among others. For instance, illicit substances like MDMA/"ecstasy," St. Imipramine is very similar to desipramine. John's wort and a few antidepressants, including SSRIs like fluoxetine and paroxetine and SNRIs like duloxetine and venlafaxine, are examples. Keep a list of everything you use and give it to your doctor and pharmacist. This list should include both prescription and over-the-counter medications as well as herbal products. Amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (like erythromycin), sparfloxacin, and a number of other medications, in addition to imipramine, may affect the heart rhythm (QT prolongation). For two weeks prior to and following treatment with this medication, most MAO inhibitors should also be avoided. Other medications can affect the removal of imipramine from your body, which may affect how imipramine works. Digoxin, disopyramide, thyroid supplements, valproic acid, and anticholinergics like atropine, belladonna alkaloids, and scopolamine are a few examples of products that may interact with this medication. A dangerous (possibly fatal) drug interaction could result from taking this medication along with MAO inhibitors. If you smoke or have recently stopped smoking, let your doctor know. Inform your doctor or pharmacist if you use any other products that make you drowsy, such as alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), sleep or anxiety medications (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or opioid painkillers (such as codeine, hydrocodone). If you also take other medications that raise serotonin, the risk of serotonin syndrome or toxicity rises. As you begin taking these medications or up the dosage, the risk of serotonin syndrome/toxicity may increase. This document does not contain all possible drug interactions.
You may become more groggy or drowsy after consuming alcohol or marijuana (cannabis). Don't use sunlamps or tanning booths. Inform your surgeon or dentist that you're taking this medication prior to the procedure. Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as desipramine, amitriptyline); or if you have any other allergies. Before using imipramine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Before taking this medication, inform your doctor or pharmacist of your medical history, especially of any of the following conditions: breathing issues (such as asthma, chronic bronchitis), personal or family history of glaucoma (angle-closure type), diabetes, eating disorders (such as bulimia), heart problems (such as arrhythmias, coronary artery disease, heart attack), liver problems, kidney problems, personal or family history of other mental/mood conditions (such as bipolar disorder, schizophrenia Check your blood sugar regularly as directed and share the results with your doctor. Children may be more sensitive to this medication's side effects, particularly its effects on the heart. Before breastfeeding, talk to your doctor. With your doctor, go over the advantages and disadvantages. Falling risks can be exacerbated by feeling lightheaded, sleepy, or confused. Till you can do it safely, avoid operating machinery, operating a vehicle, or performing other tasks that call for alertness or sharp vision. This drug should only be taken while expecting if it is absolutely necessary. Discuss the advantages and disadvantages of using this medication during pregnancy with your doctor as soon as you become pregnant, plan to become pregnant, or suspect that you may be pregnant. This medication may make it more difficult for you to manage your blood sugar if you have diabetes. Imipramine may cause a condition that affects the heart rhythm (QT prolongation). Similar pregnancy-related side effects, including urination issues, protracted sleepiness, shaking, and seizures, can be present in newborns whose mothers took these drugs. Be careful with alcohol. Limit your time in the sun. Your risk of QT prolongation may also increase if your blood contains too little potassium or magnesium. The adverse effects of this medication, particularly dizziness (which is more likely to occur when standing up), drowsiness, constipation, difficulty urinating, mental/mood changes (such as confusion, agitation), and heart effects like QT prolongation (see above), may be more severe in older adults. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Do not stop taking this medication unless your doctor instructs you to do so because untreated mental/mood issues (like depression, anxiety, and panic disorders) can be a serious condition. Ask your doctor how to use imipramine safely. If you use marijuana (cannabis), speak with your doctor. To learn more, speak with your pharmacist. If you experience skin blisters or redness, or if you get a sunburn, contact your doctor right away. If you experience symptoms like increased thirst or urination, call your doctor right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. You could become groggy, sleepy, or have blurred vision from this medication. You might become more sun-sensitive as a result of this medication. A nursing infant may experience negative side effects from this medication, which is excreted in breast milk. Inactive ingredients in this product have the potential to cause allergic reactions or other issues. You run a higher risk of developing this condition if you take certain medications (like diuretics or "water pills") or if you experience symptoms like excessive sweating, diarrhea, or vomiting. Get up slowly when leaving a seated or lying position to reduce vertigo and lightheadedness. When outdoors, apply sunscreen and don protective gear. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
When was Tofranil invented?
History of Tofranil (Imipramine) Imipramine, the active drug in Tofranil, was developed in the 1950s. It was the first drug in the tricyclic antidepressant (TCA) family.
Does Tofranil make you sleepy?
This medicine may cause tiredness, dizziness, drowsiness or blurred vision in some people. Be careful when drinking alcohol or taking pain relievers, sleeping tablets or antihistamines (medicines for colds or allergies such as hay fever) while you are taking Tofranil.
Does Tofranil help with anxiety?
When stimulants are not effective, tricyclic antidepressants (TCAs) like Tofranil are sometimes prescribed. Tofranil can be effective for adults with ADHD and also in treating symptoms of depression and anxiety that often accompany ADHD.
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