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tizanidine pills

Learn about side effects, interactions and indications. The short-acting muscle relaxant tizanidine is used to treat spasticity.

Other names for this medication:

Similar Products:
Baclofen, Robaxin, Methocarbamol, Mestinon


The general advice is to save the use of tizanidine, which has a brief duration of action, for times when there is a specific need for relief. The treatment of muscle spasticity, which can obstruct daily activities, is recommended with tizanidine.


Between doses, give 6 to 8 hours. How to stop taking this medication without risk? Speak with your doctor. Detailed Tizanidine dosage information Do not take more than 36 mg in a 24-hour period. Use this medication only as directed and never in excess of that. Observe every instruction on your prescription label. If you alter how you take tizanidine, let your doctor know if you experience any changes in side effects or in how well the medication functions. Following prolonged use, you might experience withdrawal symptoms like tremors, anxiety, fast heartbeats, and dizziness if you suddenly stop taking the medication. Store at room temperature away from heat and moisture. The side effects or effectiveness of the medication may change if you switch between tablets and capsules. Changing how you take your medication—either with or without food—can reduce its effectiveness or increase its side effects. Take tizanidine exactly as directed. Taking the capsules with food can decrease your blood levels of tizanidine. Your blood levels of tizanidine may rise if you take the tablets with food. Since tizanidine has a short half-life, its effects will peak between 1 and 3 hours after you take it. Up to three doses of 2 mg each of tizanidine are typically administered throughout the day. You risk liver damage if you take this medication in excess. You can take tizanidine with or without food as long as you take it consistently each time. You should take this medicine only for daily activities that require relief from muscle spasms. You will need frequent blood tests to check your liver function. To ensure you experience the best results, your doctor may occasionally adjust your dose.

Missed dose

To make up for a missed dose, do not take more medication. If the time for your next scheduled dose is almost up, skip the missed dose. When you remember, take the missed dose.


Call 911 right away if the victim has fallen, experienced a seizure, is having trouble breathing, or cannot be roused. Call 1-800-222-1222 to reach the poison control hotline in the event of an overdose. Additionally, information is accessible online at Drowsiness, extreme exhaustion, confusion, a slow heartbeat, dizziness, slow or shallow breathing, loss of consciousness, and drowsiness are some of the overdose symptoms that may occur.


However, you shouldn't dispose of this medication in the toilet. A medicine take-back program is the preferable method for getting rid of your medication. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more information. Keep it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and immediately stow medication up and away, out of sight, and away from reach of young children to prevent poisoning. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

For more information, speak with your doctor or pharmacist. For medical guidance on side effects, contact your doctor. The following are some of the more frequent side effects of tizanidine: dry mouth, drowsiness, weakness, and exhaustion. See the "Drug Precautions" section. Tizanidine has been linked to some serious side effects. Call 1-800-FDA-1088 to contact the FDA and report side effects.


For more details, consult your physician or pharmacist. Tell your doctor right away if you take any of the following substances: alcohol, baclofen (Lioresal), benzodiazepines like triazolam (Halcion), alprazolam (Xanax), and diazepam (Valium), as well as drugs that inhibit the CYP1A2 enzyme like zileuton (Zyflo), amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), In addition to vitamins and herbal supplements, make sure your doctor is aware of all the medications you are taking, both prescription and over-the-counter.


Do not drive or operate heavy machinery until you know how tizanidine affects you. Avoid abruptly stopping the use of tizanidine because this may cause liver damage, rebound hypertension, and tachycardia. Do not take tizanidine if you: are allergic to tizanidine or to any of its ingredients are taking medications that are strong blockers of CYP1A2 medications, including fluvoxamine (Luvox) and ciprofloxacin (Cipro, Proquin) Tizanidine's sedative effects can lead to drowsiness and dizziness, so use caution when getting up from a sitting position because dizziness could happen as a result of a lowered blood pressure. Low blood pressure is advised to be treated with liver function monitoring for the first six months and then on occasion after that. Rebound hypertension and tachycardia are two serious side effects of tizanidine that have been documented. You might experience a drop in blood pressure after taking tizanidine. Tizanidine use may cause this, but it has been shown to go away once the drug is stopped.

Can I take tramadol and tiZANidine together?

traMADol tiZANidine Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death.

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Seby Oct 25, 2013, 6:55:24 PM

The doctor may change the dose depending upon the response to the treatment. It is advised to take medicine at the same time every day and in the same manner. Tizanidine can be consumed before or after eating food. The effect of taking capsules and tablets with food and without food is different, and thus choose the best option to get better results after consulting a doctor (Tizanidine (Zanaflex) A Muscle Relaxant).

MikeInSpain May 9, 2014, 2:02:59 PM

The drug comes under the same class (what? Tizanidine is less fast and takes about 3 hours to activate. Hence Metaxalone is effective and fast as compared to Tizanidine. The side effects of Metaxalone are low as compared to Tizanidine.

Richard Aronson Apr 23, 2010, 7:11:19 AM

Avoid combination Pimozide: Zileuton may increase the serum concentration of Pimozide. If combined use is necessary, initiate tizanidine at an adult dose of 2 mg and increase in 2 to 4 mg increments based on patient response. Monitor therapy TiZANidine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of TiZANidine.

Warren McQuillan Apr 27, 2018, 12:34:01 PM

Presentation on theme: "Skeletal Muscle Relaxants"— Presentation transcript: 1 Skeletal Muscle Relaxants • Relax skeletal muscle tone Two types: Spasmolytics Reduce abnormally elevated tone caused by neurological or muscle endplate disease Without paralysis Neuromuscular blockers Induce paralysis Blockade at the motor end plate • 2 Spasmolytics Relax painful contractions/spasm of skeletal muscles • During radicular syndrome, cerebral palsy, stroke, multiple sclerosis etc. Elimination does not depend on function of liver or kidneys!!! • 5 Spasmolytics - AE Benzodiazepines Baclofen Tizanidine Sedation • Less sedative, dependence – withdrawal syndrome !! svalu šíření akčního potenciálu • 14 Suxamethonium Duration of effect - 5-10 min idiosyncrasy • mtb pseudocholinesterase idiosyncrasy Even 3-6 h paralysis Genetically reduced activity – 1:2500 Therapy – fresh frosen plasma 10 donors – contain pseudocholinesterase ventilation O depolarisaci svědčí počáteční svalové fascikulace – dlouhodobě depolarizovaná postsynaptická membrána přestane reagovat (důvod nejasný) na přítomnost molekul ACH, což má za následek myorelaxaci.

user201827 Sep 12, 2018, 3:23:43 PM

Because the therapeutic range of tizanidine is narrow, care should be exercised if it is given to patients taking oral contraceptives. Headache Results from an open-label study and a later controlled study suggested that tizanidine might be of value in the prophylaxis of chronic daily headache. It is an a-adrenergic agonist structurally related to clonidine and acts mainly at spinal and supraspinal levels to inhibit excitatory interneurones. Oral contraceptives Mean peak plasma concentrations after a single 4-mg dose of tizanidine were 3 times greater in 15 women using an oral contraceptive containing ethinylestradiol and gestodene than in controls; the elimination half-life was not, however, significantly different.

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