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Tacrolimus
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tacrolimus generic name

Additionally, it is applied topically to treat eczema. When someone receives a kidney, liver, or heart transplant, tacrolimus is used to reduce the risk of rejection.

Other names for this medication:
Advagraf, Envarsus, Protopic, Prograf, Astagraf, Modigraf

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Description

Only the lower strength (0.03%) formulation is recommended for pediatric patients between the ages of 2 and 15 while both available strengths are recommended for adult patients. In conjunction with other immunosuppressants, tacrolimus extended-release formulations are indicated for the prevention of organ rejection in adult and pediatric kidney transplant recipients as well as in patients switching from immediate-release formulations. Tacrolimus in its immediate-release forms, when taken with other immunosuppressants, is indicated for the prevention of organ rejection in adult and pediatric patients undergoing allogeneic liver, kidney, heart, or lung transplants. Topical tacrolimus ointment is recommended as a second-line therapy for non-immunocompromised adults and children with moderate-to-severe atopic dermatitis who have not responded adequately to other topical treatments or for whom alternative treatments are not recommended.

Dosage

If you have any concerns about the recommended dosage of tacrolimus, speak with your doctor. When taking tacrolimus, avoid eating grapefruit or consuming grapefruit juice. Regardless of how you feel, keep taking tacrolimus. Tacrolimus products cannot be interchanged because they release the medication in your body in different ways. Do not break open the capsules for immediate release. Your doctor will closely monitor you and change your dose as necessary. Never stop taking tacrolimus without consulting your doctor first. Do not take more or less of it or take it more often than prescribed by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow them. If any of the mixture remains, add 1 to 2 tablespoons (15 to 30 milliliters) of water to the mixture and immediately take it. If you are taking the granules for oral suspension, you will need to mix it with room temperature water before use. Mix the contents and then immediately take the mixture by mouth from the cup or with an oral syringe; do not save the mixture for a later time. Only take the tacrolimus product prescribed by your doctor and do not switch to a different tacrolimus product unless your doctor says that you should. In a cup containing the granules, add 1 to 2 tablespoons (15 to 30 milliliters) of water. Swallow the extended-release capsules and extended-release tablets whole with water; do not split, chew, or crush them. As long as you are taking tacrolimus, it can only stop your transplant from rejecting. Tacrolimus is available as a capsule, granules for oral suspension (to be combined with liquid), an extended-release (long acting) capsule, and an extended-release tablet to be swallowed. Tacrolimus is also sometimes used to treat fistulizing Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, fever, and the formation of abnormal tunnels connecting the digestive tract to other organs or the skin). Use the same dosage schedule each day for tacrolimus. As directed, take tacrolimus as directed. The risks of using this medication to treat your condition can be discussed with your doctor. Discuss your feelings throughout your treatment with your doctor. The extended-release capsules (Astagraf XL) or extended-release tablets (Envarsus XR) are usually taken every morning on an empty stomach at least 1 hour before or breakfast or at least 2 hours after breakfast. There will be some degree of granule retention. Prograf is typically taken twice daily, separated by a 12-hour period, in both oral suspension and immediate-release capsule form. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Take the oral suspension and immediate-release capsules exactly the same way every time, whether you take them with or without food.

Missed dose

To make up for a missed dose, do not take a second one. If, however, it is almost time for the subsequent dose, skip the missed one and carry on with your regular dosing schedule. Skip the missed dose and carry on with your regular dosing schedule if it has been longer than 14 hours. If it has been longer than 15 hours, skip the missed dose and carry on with your regular dosing schedule. Take the dose if it is within 14 hours of the missed extended-release capsule dose. If the extended-release tablet dose is missed, take the dose as soon as possible—preferably within 15 hours. Take the missed dose of the oral suspension or immediate-release capsule as soon as you remember.

Overdose

Canadian citizens can dial a regional poison control center. Consult your doctor for more details. Consult your pharmacist or the neighborhood waste management company. To catch up, do not double the dose. Unless specifically instructed to do so, avoid flushing or pouring medications down the drain. Store away from bathrooms. If it is near the time of the next dose, skip the missed dose. Call 911 if someone has overdosed and is exhibiting serious symptoms like fainting or difficulty breathing. If you have had an organ transplant, it is recommended that you attend a transplant education class or support group. Take the missed dose as soon as you remember it if you miss it. Pets and children should not have access to any medications. To track your progress or look for side effects, periodic laboratory and/or medical tests (such as potassium levels, blood pressure, blood sugar, tacrolimus trough level, kidney/liver function) will be done. Learn the signs of organ rejection such as a feeling of being ill, fever, or tenderness/pain around the transplanted organ. In any other case, immediately dial a poison control number. When the product has run its course or is no longer required, dispose of it properly. Away from light and moisture, keep items at room temperature. Take your next dose at the regular time. Any of these symptoms should be immediately reported to your doctor. Call 1-800-222-1222 to reach your local poison control center if you're a resident of the US.

Storage

You should not, however, dispose of this medication in the toilet. Instead, using a medication take-back program is the best way to get rid of your medication. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Keep this medication tightly closed in its original container away from the reach of children. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. Always lock safety caps and immediately store medications up and away and out of young children's sight and reach. http://www.upandaway.org Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot ingest them.

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Side effects

Abnormal dreams agitation chills blurred vision confusion cough diarrhea dizziness dry mouth fever flushed, dry skin frequent urination fruit-like breath odor general feeling of discomfort or illness headache increased hunger increased thirst increased urination itching, skin rash joint pain loss of appetite loss of consciousness loss of energy or weakness mental depression muscle pains, trembling, or twitching nausea pale skin runny nose seeing or hearing things that are not there seizures shivering sore throat stomach pain sweating swelling of the feet or lower legs tingling trembling and shaking of the hands trouble breathing trouble sleeping unexplained weight loss unusual bleeding or bruising unusual tiredness or weakness vomiting A drug may have side effects in addition to the ones that are intended. Your doctor may also be able to provide you with information on how to avoid or lessen some of these side effects. Even though not all of these side effects are likely to happen, if they do, medical attention may be required. Belching, difficulty moving, a lack of strength, stiffness in the muscles Black, tarry stools, blistering, peeling, or loosening of the skin, bloating, bloody urine, constipation, dizziness, lower back or side pain, pain and fullness in the right upper stomach, pinpoint red spots on the skin, pounding or rapid pulse, red skin lesions, often with a purple center, red, irritated eyes, skin sores, ulcers, or white spots in the mouth or on the lips, weakness, and weight gain. Any of the following side effects should be discussed with your doctor right away: If any of the following side effects persist, are bothersome, or if you have any questions about them, consult your doctor: Increased pain sensitivity, chest pain, muscle cramps, numbness or pain in the legs, ringing in the ears, and cramps in the muscles Enlarged heart flushing of the face or neck weight loss unidentified incidence Less common More common Rare Some side effects may occur that usually do not need medical attention. As your body gets used to the medication, these side effects might go away during treatment.

Interactions

Prevent drinking. Don't consume anything with grapefruit. When tacrolimus is administered along with aluminum or magnesium hydroxide antacids, the serum level of tacrolimus may rise, increasing the possibility of toxicity. Consuming alcohol may increase the rate of tacrolimus release from extended-release formulations. Exercise caution with St. Johnson's Wort As coadministration with food reduces the rate and extent of absorption, take at least 1 hour before or 2 hours after a meal. The same time each day, take. Take on an empty stomach. Away from antacids; take separately. This herb induces the CYP3A4 metabolism of tacrolimus; therefore, monitoring tacrolimus whole blood trough concentrations may be warranted.

Contraindications

Anaphylactic reactions to IV formulation. Stay out of the sun and UV rays for extended periods of time. sugar diabetes. Driving and using large machinery shouldn't be done until you know how tacrolimus affects you. If you have an allergy to tacrolimus or any of its ingredients, avoid taking it. Acute or long-term kidney damage is possible; if kidney function declines, tacrolimus dosage should be decreased. Hypertension. Analyze blood sugar levels carefully. Monitor blood pressure regularly, and review medication list for relevant drug-drug interactions that may influence blood pressure. Nephrotoxicity. Nephrotoxicity: If acute or long-term kidney damage occurs, tacrolimus dosage should be decreased to prevent further kidney damage. Oral/injectable: Lymphoma and other cancers are among the serious side effects of tacrolimus that have been reported. Tacrolimus may make patients more susceptible to developing new cases of diabetes, which are a risk after transplant. Combination immunosuppression should be used with caution because patients receiving tacrolimus have an increased risk of bacterial, viral, fungal, and protozoal infections, including opportunistic infections. The signs and symptoms of anaphylaxis, such as hives, rash, itching, and trouble breathing or swallowing, may appear in patients receiving tacrolimus injection. severe infections Tacrolimus poses a risk for increased blood pressure that may require antihypertensive therapy. Tell your healthcare provider right away if you have any of the following signs or symptoms while receiving tacrolimus, which may suggest a serious reaction: decreased urination pain or burning on urination swelling of the arms, hands, feet, ankles or lower legs weight gain unusual bleeding or bruising seizures coma (loss of consciousness for a period of time) Topical: Serious side effects have been reported with topical tacrolimus including the following: Lymphoma and other malignancies: The risk of lymphomas after transplant appears related to intensity and duration of use of tacrolimus. If you experience any of the following while using tacrolimus ointment, it could be a sign of a serious reaction: swollen glands rash crusting, oozing, blistering or other skin infection symptoms cold sores chicken pox or other blisters swelling of the hands, arms, feet, ankles, or lower legs Tacrolimus can cause blurred vision, dizziness, and sleepiness. The frequency and length of tacrolimus use appear to be related to the risk of lymphomas after transplant. Use caution with other nephrotoxic drugs.

What is tacrolimus Prograf used for?

Tacrolimus (Prograf ®) is an immunosuppressant drug used to prevent and treat organ rejection in children who have had liver transplants.

What does tacrolimus do in dogs?

Tacrolimus is useful in treating dry eye (keratoconjunctivitis sicca) and CSK (chronic superficial keratitis) in dogs. It may also useful in treating immune-mediated keratitis and pannus in horses and dogs.

What is tacrolimus test used for?

Tacrolimus test is ordered to determine the level of the drug tacrolimus in your blood. This test is ordered before the doctor puts you on therapy. This is an immune suppressant drug that is usually given before a transplant.

What is tacrolimus ointment used for?

Tacrolimus topical is used on the skin to treat moderate to severe atopic dermatitis in patients who have received other medicines that have not worked well. Atopic dermatitis is a skin condition where there is itching, redness, and inflammation, much like an allergic reaction.

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Testimonials
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Graham Thurston Sep 17, 2011, 5:27:29 PM

In clinical practice, whole blood trough levels have generally been in the range 5-20 ng/ml in liver transplant recipients and 10-20 ng/ml in kidney and heart transplant patients in the early post-transplant period. Administration should commence approximately 12 hours after the completion of surgery. As the pharmacokinetics of tacrolimus are unaffected by renal function, no dose adjustment should be required.

Martin Ince Jan 10, 2018, 11:25:49 PM

Therefore, changes in TTL-SD and TTL-CV in stable KTRs with no tacrolimus dose change require medical interest and attention. The higher the TTL-mean, the higher the TTL-SD. This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients > 5 years after kidney transplantation (KT). Medical chart data, including TTL, graft rejection, and tacrolimus dose change during a 2-year period, between January 2017 and December 2018, were collected. Tacrolimus dose change significantly predicted the TTL-CV (p = .008).

shanemcd Jan 12, 2012, 4:56:36 PM

Key Words: antifungal drug coverage, conversion factors, graft-versus-host disease, hematopoietic stem-cell transplant, HLA-matched donor, tacrolimus therapeutic levels J Hematol Oncol Pharm. To reach therapeutic tacrolimus levels, the patient had to be within the target range on 2 consecutive testings at least 24 hours apart. In a multivariate regression analysis, a 4/8 human leukocyte antigen (HLA)-matched donor significantly (P = .001) increased the time to target tacrolimus levels, and the incidence of diarrhea, although not significant (P = .093), resulted in increased time to reaching target tacrolimus levels.

user60951 Apr 28, 2013, 5:44:19 PM

Advagraf doses are usually reduced in the post-transplant period. Patients should be maintained on a single formulation of tacrolimus with the corresponding daily dosing regimen; alterations in formulation or regimen should only take place under the close supervision of a transplant specialist (see sections 4.4 and 4.8). The relationship between tacrolimus trough levels (C) and systemic exposure (AUC) for Advagraf is similar to that of Prograf.

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