Side effects
If you have: Call your doctor for medical advice about side effects. The following are possible side effects of Sustiva: If you experience any of these side effects, even if you have before, call your doctor right away. Your immune system is impacted by efavirenz, which may result in some side effects (even weeks or months after you've taken this medication). If you experience any of the following symptoms of an allergic reaction to Sustiva: hives, difficulty breathing, swelling of the face or throat, or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling), seek emergency medical attention. Confusion, a sense of sadness or hopelessness, suicidal thoughts, anxiety, paranoia, hallucinations, difficulty speaking or moving, and unusual behavior are just a few of the serious psychiatric symptoms that sutiva may bring on. The negative effects of Sustiva Inform your physician if you have: There may be additional side effects; this is not a comprehensive list. You can contact the FDA to report side effects at 1-800-FDA-1088. a seizure, hallucinations, difficulty concentrating, trouble speaking or moving (these symptoms may appear months or years after you begin taking efavirenz), nervous system issues such as dizziness, drowsiness, confusion, difficulty concentrating, strange dreams, insomnia, or issues with speech, balance, or muscle movement, severe psychiatric symptoms such as anxiety, paranoia, unusual behavior, feeling down or hopeless, hallucinations, or suicidal thoughts, or liver issues Changes in the shape or location of body fat, particularly in the arms, legs, face, neck, breasts, and waist, as well as nausea, vomiting, dizziness, drowsiness, trouble concentrating, rash, headache, and fatigue. Signs of a new infection include fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss, difficulty speaking or swallowing, issues with balance or eye movement, weakness or a prickly feeling, swelling in your neck or throat (enlarged thyroid), menstrual changes, and impotence.
Interactions
Prescription and over-the-counter medications, vitamins, and herbal products, among others, may interact with efavirenz. Some medications can change the levels of other medications you take in your blood, which could increase side effects or reduce the effectiveness of the medication. Utilizing certain medications concurrently is occasionally not advised. A serious heart issue may result from taking sutiva. Sustiva drug interactions (detailed information) Inform your doctor about all of the medications you are taking now as well as any new or discontinued ones. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Contraindications
If you want to get pregnant, consult your doctor as well. Additionally, Sustiva may enter breast milk and seriously harm the infant. Do not breast-feed if you are taking Sustiva. If you are allergic to any of the inactive ingredients or the active ingredient, efavirenz, do not take Sustiva. Never take any additional medications without first consulting your doctor. Whether Sustiva was responsible for these flaws is unknown. John's wort (Hypericum perforatum). extended QTc. Some children's rashes could be a serious issue. Animals and pregnant women who took Sustiva have both experienced serious birth defects in their offspring. After treatment is stopped, sutiva may continue to circulate in your blood for some time. Sustiva may have more side effects, such as drowsiness, when combined with alcohol or other drugs that have similar side effects. If you are nursing a child, discuss this with your doctor. If you experience any side effects while your child is taking Sustiva, including rash, call your doctor right away. Tell your doctor right away if you are pregnant. The Centers for Disease Control and Prevention advise against breastfeeding for mothers who have HIV because the virus can be transmitted to the child through the mother's milk. As a result, you should keep using birth control for 12 weeks after stopping Sustiva. These medicines include prescription and nonprescription medicines and herbal products, especially St. Even if they also use other birth control options, women must use a reliable barrier method of contraception, such as a condom or diaphragm. Sustiva should not be used by women while they are trying to get pregnant or for 12 weeks after they stop. Women should not rely only on hormone-based birth control, such as pills, injections, or implants, because Sustiva may make these contraceptives ineffective. You may need to stop breast-feeding or use a different medicine. The other medications you are taking that could raise your risk for QTc prolongation will be evaluated by your doctor to determine whether any changes to them are necessary.
Telaprevir (Incivek) is not combined with carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, and St. John's wort because they can increase the breakdown of telaprevir and decrease the effectiveness. Telaprevir should be used with caution with warfarin (Coumadin) because telaprevir can increase or decrease warfarin (Coumadin) breakdown, increasing or decreasing the effect of warfarin. Telaprevir can slow the breakdown of these medications and increase their levels in the body, leading to increased side effects and toxicity.
A mark against this young prince is its orphan status. Next in line for the title is the co-formulation of rilpivirine (TMC278) and Truvada (which is itself a combination of tenofovir + emtricitabine). Although no new data were presented on rilpivirine at this conference, the phase 3 results are expected to be available in several months.
Atripla may lead to bone problems, including bone pain or bones getting soft or thin, which may lead to fractures. A generic version became available in the U.S. in October 2020. The efavirenz in Atripla can significantly decrease the effectiveness of Vfend; Vfend can significantly increase the risk of efavirenz side effects. Consult the Atripla package insert for more details: http://packageinserts.bms.com/pi/pi_atripla.pdf Before taking this medication, tell your doctor if you have kidney disease, liver disease (including hepatitis B), or a history of depression/suicidal thoughts. These include: Combivir, Epivir, Epzicom, Rescriptor, Triumeq, Trizivir, and Viramune.
As with other antiviral agents in this class, the greatest safety concern is that it may reactivate hepatitis B virus (HBV) in coinfected patients. Although no participants in premarketing studies experienced reactivation, patients should be monitored for HBV reactivation during and after treatment. Glecaprevir/pibrentasvir is not recommended for patients with moderate to severe hepatic impairment (Child-Pugh class B and C). Glecaprevir/pibrentasvir has the potential to interact with several drugs, such as rifampin, atazanavir (Reyataz), carbamazepine (Tegretol), efavirenz (Sustiva), and St. John's wort.