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sulfasalazine dose pediatric

It reduces swelling and inflammation inside the body. In children who have not responded to other medications, sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat polyarticular juvenile idiopathic arthritis (PJIA), a type of childhood arthritis that affects five or more joints during the first six months of the condition and causes pain, swelling, and loss of function. Adults with rheumatoid arthritis who have not responded well to other medications or who could not tolerate them are treated with sulfasalazine delayed-release (Azulfidine EN-tabs). Sulfasalazine belongs to the group of drugs known as anti-inflammatory drugs. Sulfasalazine is used to treat ulcerative colitis, a condition that leads to swelling and sores in the lining of the colon and rectum, as well as to maintain symptom improvement.

Other names for this medication:
Salazopyrin En-Tabs, Salazopyrin, Azulfidine

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For the treatment of active Crohn's disease, particularly in cases where the colon has been affected. Sulfasalazine is indicated in: Rheumatoid arthritis & Juvenile arthritis: In the treatment of patients with rheumatoid arthritis and pediatiric patients with polyarticular-course juvenile rheumatoid arthritis, who have responded inadequately to salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs). Ulcerative colitis and Crohn's Disease: Used in conjunction with the standard dietary and supportive therapy for ulcerative colitis.


Even if you feel well, keep taking the sulfasalazine medication. Without consulting your doctor, never stop taking sulfasalazine. Never take it in larger or smaller amounts or more frequently than directed by your doctor. Sulfasalazine should be taken with plenty of fluids. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. For treatment of rheumatoid arthritis or polyarticular juvenile idiopathic arthritis, sulfasalazine delayed-release tablets are usually taken twice a day in evenly spaced doses throughout the day. It usually is taken 3 to 6 times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Sulfasalazine comes as regular and delayed-release (releases the medication in the intestine to prevent irritation to the stomach and to allow the medication to work in the intestine where its effects are needed) tablets. Sulfasalazine is also used to treat Crohn's disease-related abdominal pain, diarrhea (frequent stools), rectal bleeding, and bowel inflammation. Do not crush or chew delayed-release tablets; instead, swallow them whole. Take sulfasalazine after a meal or with a light snack, then drink a full glass of water. Sulfasalazine should be taken exactly as prescribed. If you use this medication to treat your condition, discuss any potential risks with your doctor.

Missed dose

Do not take two doses at once. Simply take your next dose when it is due if it is almost time for one. Sulfasalazine should be taken as soon as you remember if you miss a dose.


Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room if you take too much sulfasalazine.


You shouldn't flush this medication down the toilet, though. The best way to get rid of your medication is instead through a medication take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication tightly closed in the original container and out of the reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. It should not be kept in the bathroom. Store it at room temperature, away from sources of extreme heat and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. Always lock safety caps and immediately stow medication up and away, out of sight, and away from reach of young children to prevent poisoning. In order to prevent pets, kids, and other people from ingesting leftover medications, they should be disposed of in a specific manner.

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Side effects

Call your physician for advice on possible side effects. Consult your doctor or pharmacist for more details. Less frequent side effects are: See "Important information" above. A yellow-orange discoloration of the skin or urine is another side effect of sulfasalazine. the negative effects of sulfasalazine Sulfasalazine's most frequent negative effects include: These are not all the possible side effects of sulfasalazine. Contact the FDA at 1-800-FDA-1088 to report side effects. reversible oligospermia, anorexia, headache, nausea, and vomiting. skin rash pruritus urticaria fever Heinz body anemia hemolytic anemia cyanosis


In the treatment of active Crohn's disease, especially in patients with colonic involvement. In the treatment of rheumatoid arthritis patients and pediatric patients with polyarticular-course juvenile rheumatoid arthritis who have not responded adequately to salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs), sulfasalazine is recommended. Ulcerative colitis and Crohn's Disease: As adjunct in the treatment of ulcerative colitis with the usual supportive and dietary measures.


Wear protective clothing, sunglasses, and sunscreen, and avoid unnecessary or prolonged sun exposure. If you have an enzyme disorder called porphyria, this medication may make your skin more sensitive to sunlight. If you are allergic to sulfasalazine, its metabolites, sulfonamides, or salicylates.

What is the side effect of sulfasalazine?

Sulfasalazine may cause your urine to change colour, to orange, but this is nothing to worry about. It may also stain tears and soft contact lenses yellow. Sulfasalazine is not thought to increase risk of infection, unless it causes the rare side effect of low white blood cells.

Is sulfasalazine a sulfonamide drug?

However, the anti-inflammatory drug sulfasalazine represents an important exception. Used in rheumatic diseases, it is classified as a non-antibiotic sulfonamide, but is structurally related to antibiotic sulfonamides.

How long does it take to work?

Sulfasalazine does not work straight away. If you're taking sulfasalazine for inflammatory bowel disease, you must continue taking it even if you feel well in order to remain well. If you have rheumatoid arthritis it may take 1 to 3 months before you notice your symptoms get better. It depends on how high your dose is and how severe your symptoms are.

Will sulfasalazine affect my fertility?

There's no evidence to suggest that taking sulfasalazine will reduce fertility in women. Women should take high dose folic acid (5mg a day) if trying to get pregnant. There are some reports of sulfasalazine reducing sperm count in men. This usually gets better 2 to 3 months after stopping treatment. If you are a man, and are having difficulty in conceiving after 12 months of trying, then you may wish to discuss stopping sulfasalazine with your doctor.

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Marie Hunt Jul 19, 2013, 6:29:38 PM

Your doctor will tell you how much to take and when to take it, and these directions will also be printed on the label of the pack to remind you about what the doctor said to you. Your dose will depend upon the reason why you have been prescribed sulfasalazine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. If you have ever had an allergic reaction to a medicine.

yakarteek Jun 14, 2017, 2:42:14 PM

Management of Mild-to-Moderate Ulcerative Colitis – Summary of Recommendations from the American Gastroenterological Association 1. In patients with extensive mild–moderate ulcerative colitis (UC), the AGA recommends using either standard-dose mesalamine (2–3 g/d) or diazo-bonded 5-ASA rather than low-dose mesalamine, sulfasalazine, or no treatment. In patients with extensive or left-sided mild–moderate UC, the AGA suggests ...

zozoXD Dec 16, 2018, 8:51:13 AM

The sulfa group is readily absorbed by the liver and is responsible for some of the drug’s potential adverse side effects. Sulfasalazine Sulfasalazine has been used for decades for maintaining remission of ulcerative colitis. Compounds in this class contain 5-aminosalicylic acid (5-ASA), also known as 5-aminosalicylate. Taking a 5-ASA drug by mouth may allow the medication to break down throughout the whole gastrointestinal tract.

user97725 Jul 6, 2020, 9:56:56 PM

The best way to find out how much you will pay is to contact your insurance or Medicare prescription plan for up-to-date coverage information. 5-ASAs can be administered orally, as tablets or capsules, or rectally, as enemas or suppositories. A woman’s healthcare provider is the best source of information when deciding to start or continue 5-ASAs during pregnancy or while breastfeeding. Dipentum releases mesalamine by allowing bacteria in the colon to activate it from its carrier.

Huginn Apr 22, 2011, 8:20:17 AM

A side effect is an unwanted response to a medication when it is taken in normal doses. It is most likely to occur during the first three months of taking sulfasalazine, but may happen at any point during treatment. As well, some forms of this medication may not be used for all of the conditions discussed here. It may take 1 to 2 months before you see any results.

Nagarjun Prasad Sep 7, 2019, 8:54:10 AM

How to use sulfasalazine suppositories Sulfasalazine suppositories are used to treat inflammatory bowel disease. If you often forget doses, it may help to set an alarm to remind you. Also clean around your bottom (anus) with mild soap and water, rinse and pat dry. They may need to monitor you for side effects.

Xexendra May 14, 2021, 1:46:48 AM

• Methotrexate (MTX) is perhaps the oldest and most commonly used cDMARD on the market. They work to keep RA activity levels at their lowest possible levels within the body. Despite no definitive cure for RA, there is no lack of options for treatment.

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