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Sofosbuvir
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sofosbuvir daclatasvir price

Includes sofosbuvir indications, interactions, and side effects. Hepatitis C infections are treated with sofosbuvir in conjunction with other antiviral drugs.

Other names for this medication:
Sovaldi, Harvoni, Vosevi, Epclusa

Similar Products:
Lamivudine, Daklinza, Epivir, Truvada, Daclatasvir, Emtricitabine, Efavirenz, Tenvir, Ledipasvir, Ribavirin, Copegus, Sustiva, Atripla, Lopinavir, Kaletra, Viraday, Ritonavir, Tenofovir

Description

Sofosbuvir combines with HCV RNA by the NS5B polymerase and functions as a chain terminator after intracellular metabolism to produce the pharmacologically active uridine analog triphosphate (GS-461203). More specifically, sofosbuvir stops the replication of HCV genetic material by interacting with the two Mg2+ ions found in the GDD active site motif of HCV NS5B polymerase. The nucleotide analog inhibitor sofosbuvir specifically prevents HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase from functioning.

Dosage

Taken once daily, with or without food, one 400 mg tablet. When treating patients with genotype 1 infection who are ineligible for interferon, sofosbuvir should be used in conjunction with ribavirin. For the treatment of CHC, should be used in conjunction with Ribavirin or in conjunction with Pegylated Interferon and Ribavirin.

Missed dose

Never combine two doses into one. Before you completely run out of medication, have your prescription filled. If your next dose is almost due, skip the missed dose and take the medication as soon as you remember.

Overdose

If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Dial 1-800-222-1222 to reach the poison control hotline in the event of an overdose. At https://www.poisonhelp.org/help, you can also find information online.

Storage

Keep in a dry, cool environment. Keep away from children's reach. Protect from light.

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Side effects

Fatigue and headache were the most frequently reported side effects (incidence greater than or equal to 20%, all grades) when sofosbuvir and ribavirin were combined. Fatigue, headache, nausea, insomnia, anemia, pruritus, asthenia, rash, decreased appetite, chills, influenza-like illness, pyrexia, diarrhea, neutropenia, myalgia, and irritability were the most frequent adverse reactions seen with sofosbuvir combined with Peginterferon alfa and Ribavirin.

Interactions

Sofosbuvir and numerous medications can interact. Not all possible interactions are covered here. Drug interactions for sofosbuvir (detailed information) Other medications you take may have their blood levels affected by certain medications, which could increase their side effects or reduce their efficacy. Utilizing certain medications concurrently is occasionally not advised. Inform your doctor about all of your current medications as well as any new or discontinued ones. This includes vitamins, herbal products, prescription and over-the-counter medications. When you start or stop taking sofosbuvir, your doctor may need to adjust the doses of any other medicines you take on a regular basis.

Contraindications

If you experience light-colored stools, weakness, fatigue, nausea, vomiting, yellow eyes or skin, loss of appetite, or any of the other symptoms listed above, call your doctor right away. During treatment and for six months after treatment with sofosbuvir and ribavirin or in combination with peginterferon alfa and ribavirin, both females and males must use two reliable methods of birth control. Before beginning treatment with sofosbuvir and ribavirin or in combination with peginterferon alfa and ribavirin, as well as each month while receiving treatment, as well as for six months after treatment is finished, females must have a negative pregnancy test. If you are also infected with HIV and taking medicines to treat your HIV infection, an Antiretroviral Pregnancy Registry is also available at 1-800-258-4263. Do not take these medications if you are pregnant, planning to become pregnant, or if your sexual partner is. If you or your female sexual partner becomes pregnant while taking or within 6 months after you stop taking sofosbuvir and ribavirin, or sofosbuvir in combination with peginterferon alfa and ribavirin, tell your healthcare provider right away. To treat chronic hepatitis C infection, sofosbuvir and ribavirin should be taken together, or sofosbuvir and peginterferon alfa should be combined. Sofosbuvir, in combination with ribavirin or peginterferon alfa and ribavirin, may cause birth defects or death of your unborn baby. Discuss the various birth control methods that might be used at this time with your healthcare provider. Information is gathered by the Ribavirin Pregnancy Registry about what happens to mothers and their unborn children when the mother uses ribavirin while she is pregnant. These could be indications that your liver is seriously damaged. Call 1-800-593-2214 to get in touch with the Ribavirin Pregnancy Registry if you or your healthcare provider want more information. You should avoid getting pregnant while taking sofosbuvir with ribavirin, in combination with peginterferon alfa and ribavirin, and for six months after treatment is finished. This applies to both you and your sexual partner. Taking sofosbuvir by itself is not advised.

How much does Sofosbuvir cost without insurance?

Sofosbuvir (Sovaldi): This medication costs $1,000 per 400 mg pill. The total cost for a 12-week course is around $84,000, and doctors will typically prescribe it with other medicines, such as simeprevir.

What are ledipasvir and sofosbuvir tablets used for?

Ledipasvir and sofosbuvir combination is used with or without ribavirin to treat chronic hepatitis C infection in adults and children 3 years of age and older (including liver transplant patients, with or without cirrhosis). This medicine is available only with your doctor's prescription.

Is sofosbuvir and velpatasvir the same as Epclusa?

Epclusa (sofosbuvir / velpatasvir) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value.

Does ledipasvir and sofosbuvir work?

Generic Name: ledipasvir-sofosbuvir These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

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Testimonials
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Mohamed Hamouda Jun 9, 2011, 3:02:56 PM

In the process of treatment it is necessary to combine Sofosbuvir with other drugs against hepatitis C. Novisof is not suitable for monotherapy. It is important to take Novisof at the same time and avoid overdosing. SIDE EFFECTS • Novisof causes side effects only in rare cases. Novisof is a modern drug against the hepatitis C virus. The duration of treatment is determined by the doctor.

Miroslav Mihaylov Oct 8, 2019, 10:01:42 PM

Brand name - Ledviclear • Generic name - Sofosbuvir/Ledipasvir Manufacturer - Abbott Salt composition - Sofosbuvir 400mg + Ledipasvir 90mg Storage - Store at room temperature (10-30°C) Dosage form - Oral (tablet) Strength - 400 Mg + 90 mg Packaging - Bottle of 28 tablets Gender - Unisex Prescription required -Yes Indication - Used in the treatment of chronic Hepatitis C Virus (HCV) infection Ledviclear tablet is a combination of two antivirals, namely Sofosbuvir and Ledipasvir. Ledviclear (Ledipasvir and Sofosbuvir) tablets are used in the treatment of Chronic Hepatitis C Virus (HCV) infection in adults. Ledipasvir inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. The active ingredient of Ledviclear tablet is Sofosbuvir/Ledipasvir (400mg/90mg). Ledviclear (400mg/90mg) tablet works to reduce the multiplication of virus in the body, and eliminates the virus from the body over a period of time.

glitchform Feb 13, 2016, 5:10:47 AM

Ledipasvir inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. The active ingredient of Ledikast tablet is Sofosbuvir/Ledipasvir (400mg/90mg). This medication is used in the treatment of chronic (long lasting) Hepatitis C Virus (HCV) infection in adults.

Mensah George May 17, 2021, 4:07:50 AM

Hepcinat LP (Ledipasvir 90 mg/sofosbuvir 400 mg) - generic Harvoni of Natco available in bottle of 28 tablets. Precautions Patients who are undergoing treatment for Hepatitis C with Hepcinat LP (Ledipasvir 90 mg/sofosbuvir 400 mg) - generic Harvoni will require regular visits to their physician or the hospital so that routine blood tests can be carried out. Hepcinat LP (Ledipasvir 90 mg/sofosbuvir 400 mg) - generic Harvoni of Natco, mechanism of action involves inhibiting the enzyme which is necessary for the virus if it is to multiply.

ogechi egbeyemi Dec 20, 2014, 11:49:59 AM

Generally it seems wise to have a doctor’s prescription as well. The Australian government’s position on this is very clear and very accessible. He spoke to me about my liver enzyme level test results. https://www.tga.gov.au/personal-importation-scheme Importing Sofosbuvir for personal use into the UK or the USA.

SkinWallker Nov 10, 2012, 10:29:44 AM

What are the side effects of the Myhep Sofosbuvir tablet? Modern Times Helpline Pharma is one of the best suppliers of Myhep Tablet in India and has good reviews from our customers. Why you should order Myhep Tablet from the Modern Times Helpline?

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