Fatigue and headache were the most frequently reported side effects (incidence greater than or equal to 20%, all grades) when sofosbuvir and ribavirin were combined. Fatigue, headache, nausea, insomnia, anemia, pruritus, asthenia, rash, decreased appetite, chills, influenza-like illness, pyrexia, diarrhea, neutropenia, myalgia, and irritability were the most frequent adverse reactions seen with sofosbuvir combined with Peginterferon alfa and Ribavirin.
Sofosbuvir and numerous medications can interact. Not all possible interactions are covered here. Drug interactions for sofosbuvir (detailed information) Other medications you take may have their blood levels affected by certain medications, which could increase their side effects or reduce their efficacy. Utilizing certain medications concurrently is occasionally not advised. Inform your doctor about all of your current medications as well as any new or discontinued ones. This includes vitamins, herbal products, prescription and over-the-counter medications. When you start or stop taking sofosbuvir, your doctor may need to adjust the doses of any other medicines you take on a regular basis.
If you experience light-colored stools, weakness, fatigue, nausea, vomiting, yellow eyes or skin, loss of appetite, or any of the other symptoms listed above, call your doctor right away. During treatment and for six months after treatment with sofosbuvir and ribavirin or in combination with peginterferon alfa and ribavirin, both females and males must use two reliable methods of birth control. Before beginning treatment with sofosbuvir and ribavirin or in combination with peginterferon alfa and ribavirin, as well as each month while receiving treatment, as well as for six months after treatment is finished, females must have a negative pregnancy test. If you are also infected with HIV and taking medicines to treat your HIV infection, an Antiretroviral Pregnancy Registry is also available at 1-800-258-4263. Do not take these medications if you are pregnant, planning to become pregnant, or if your sexual partner is. If you or your female sexual partner becomes pregnant while taking or within 6 months after you stop taking sofosbuvir and ribavirin, or sofosbuvir in combination with peginterferon alfa and ribavirin, tell your healthcare provider right away. To treat chronic hepatitis C infection, sofosbuvir and ribavirin should be taken together, or sofosbuvir and peginterferon alfa should be combined. Sofosbuvir, in combination with ribavirin or peginterferon alfa and ribavirin, may cause birth defects or death of your unborn baby. Discuss the various birth control methods that might be used at this time with your healthcare provider. Information is gathered by the Ribavirin Pregnancy Registry about what happens to mothers and their unborn children when the mother uses ribavirin while she is pregnant. These could be indications that your liver is seriously damaged. Call 1-800-593-2214 to get in touch with the Ribavirin Pregnancy Registry if you or your healthcare provider want more information. You should avoid getting pregnant while taking sofosbuvir with ribavirin, in combination with peginterferon alfa and ribavirin, and for six months after treatment is finished. This applies to both you and your sexual partner. Taking sofosbuvir by itself is not advised.