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Daclatasvir
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daclatasvir side effects

In conjunction with other antiviral medications, daclatasvir, a direct-acting antiviral agent, is used to treat particular hepatitis C virus (HCV) infections.

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Description

Daclatasvir is demonstrated to disassemble hyperphosphorylated NS5A proteins, interfering with the operation of fresh HCV replication complexes. It can attach to the RNA of the HCV. It is also reported that daclatasvir also blocks both intracellular viral RNA synthesis and virion assembly/secretion in vivo. Using phosphorylated states as a guide, it is demonstrated that it performs two different functions in HCV RNA replication. The trans-acting activity of NS5A that is hyperphosphorylated regulates HCV assembly and infectious particle formation, while the cis-acting activity of basally phosphorylated NS5A mediates the maintenance of the HCV replication complex. A functional replication complex responsible for viral RNA genome amplification on endoplasmic reticulum membranes includes the viral nonstructural phospoprotein NS5A.

Dosage

For a copy of the manufacturer's information for the patient, ask your pharmacist or doctor. Continue to take daclatasvir even if you feel well. Daclatasvir comes as a tablet to take by mouth. Sofosbuvir and daclatasvir must be taken together for a minimum of 12 weeks. Take care not to stop taking daclatasvir or sofosbuvir without first consulting your physician. Never take it in quantities or frequencies other than those recommended by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow them. It is usually taken with or without food once a day. Take daclatasvir at roughly the same time each day. Utilize daclatasvir as prescribed. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Continue eating normally unless your doctor instructs you otherwise.

Missed dose

Never take two doses on the same day. To continue with your regular dosing schedule, skip the missed dose if you don't remember it until the following day. Take the missed dose as soon as you remember it if you remember the missed dose on the day you were supposed to take it.

Overdose

If you take too much daclatasvir call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Storage

Store at room temperature below 30°C, protect from light. keep out of the reach of children.

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Side effects

Any of the following symptoms, including fainting or near-fainting, dizziness or lightheadedness, feeling unwell, weakness, exhaustion, shortness of breath, chest pain, confusion, and memory issues, may occur. Serious Symptomatic Bradycardia When Coadministered with Sofosbuvir and Amiodarone is one of the severe adverse reactions that are detailed below and elsewhere in the labeling.

Interactions

Adults who have a chronic hepatitis C virus (HCV) infection should take Daclatasvir along with Sofosbuvir to treat their condition.

Contraindications

When taken with amiodarone, a medication used to treat some heart conditions, daclatasvir combination therapy with sofosbuvir may cause heart rate (pulse) slowing as well as other symptoms. When taking strong CYP3A4 inducers like carbamazepine (Tegretol, Equetro, Carbatrol), phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), St. John's wort, and nimodipine (Nimotop), daclatasvir should not be taken alone. If you are taking amiodarone along with sofosbuvir and Daclatasvir and experience any of the following symptoms, seek medical attention right away: fainting or near-fainting weakness fatigue shortness of breath chest pain confusion memory issues. You should also contact your doctor right away if you experience weakness, fatigue, nausea, vomiting, yellow eyes or skin, loss of appetite, or light-colored stools. Serious side effects have been reported with daclatasvir including the following: Slow heart rate (bradycardia). These could be indicators of a serious liver condition. Use daclatasvir in combination with sofosbuvir.

What is sofosbuvir used for?

Sofosbuvir is used along with ribavirin (Copegus, Rebetol, Ribasphere, others) and sometimes another medication (peginterferon alfa [Pegasys]) to treat certain types of chronic hepatitis C (an ongoing viral infection that damages the liver) in adults.

What class of drug is Daclatasvir?

Daclatasvir is in a class of antiviral medications called hepatitis C virus (HCV) NS5A inhibitors. It works by stopping the virus that causes hepatitis C from spreading inside the body. It is not known if daclatasvir prevents the spread of hepatitis C to other people.

What class of drug is daclatasvir?

Daclatasvir is in a class of antiviral medications called hepatitis C virus (HCV) NS5A inhibitors. It works by stopping the virus that causes hepatitis C from spreading inside the body. It is not known if daclatasvir prevents the spread of hepatitis C to other people.

How much does daclatasvir cost?

A 12-week course of daclatasvir is priced at US$63,000 in the US [3].

What does daclatasvir treat?

Why is this medication prescribed? Daclatasvir is used along with another medication (sofosbuvir [Solvadi]) to treat a certain type of chronic hepatitis C (an ongoing viral infection that damages the liver). Daclatasvir is in a class of antiviral medications called hepatitis C virus (HCV) NS5A inhibitors.

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Testimonials
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njeru May 19, 2010, 7:31:53 PM

Dicho esto, una o dos tazas de café o té no son ningún problema. La razón de esto es que las enzimas, llamadas enzimas CYP, utilizadas por el cuerpo para eliminar la cafeína de la sangre son de la misma familia de enzimas que el cuerpo utiliza para eliminar Sofosbuvir y Daclatasvir de la sangre. Los altos niveles de cafeína pueden crear una situación de “dosis insuficiente”. Usted necesitaría comer acerca de varias toronjas para hacer una diferencia realmente significativa.

user1125807 May 9, 2012, 2:06:43 PM

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goten Jan 14, 2021, 1:06:40 AM

The combination was approved and is used in the treatment of HCV in treatment-naive or treatment-experienced patients with chronic HCV genotype 1 or 3 infections. The active ingredient of the Dalsiclear The combination of daclatasvir (DCV), sofosbuvir (SOF), and ribavirin (RBV) is a direct-acting antiviral (DAA) regimen for the treatment of hepatitis C virus (HCV) infection. Do not consume this medicine in case you have an allergy to any of the ingredients of Alternate brands

Lisa Biesinger Aug 4, 2019, 1:29:14 AM

STORAGE CONDITIONS • In a dry, dark place, out of reach of small children. But if more than 20 hours have passed, you should take a pill, and postpone the next one the next day. The price of DaclaHep is indicated per package (28 tablets).

Achintya Idam Jun 9, 2019, 2:34:53 PM

Patients who had not previously received any treatment recovered after 8 weeks in 95% of cases. Basically, the drug is well tolerated and does not cause concern to the patient. Compared to him, Sovihep-Dacihep contributes to recovery much faster and with fewer side effects.

azrul Oct 9, 2015, 2:10:56 AM

People with genotype 3 should always consider doing a longer treatment time than genotypes 1 or 2 as G3 has proved to only give about a 93% cure rate from 12 weeks of treatment. For example if you compare genotypes with breeds of dogs; different breeds of dogs have similar features but also significant differences. Of these three HCV genotypes it is genotype 3 that is the most difficult to cure.

Ben Morton Dec 16, 2011, 12:04:54 AM

Daclatasvir mepesuccinate is Generic Name for the trade name drug Hepcdac. There are no data available demonstrating improvement in patient reported outcomes or survival with Hepcdac . It is not known whether daclatasvir passes into breast milk or if it could harm a nursing baby.

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