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sertraline amitriptyline interaction

A selective serotonin reuptake inhibitor (SSRI) known as sertraline is approved to treat major depressive disorder, social anxiety disorder, and a variety of other psychiatric conditions.

Other names for this medication:

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When someone has symptoms of depression, panic, anxiety, or obsessive-compulsive disorder, sertraline alters brain chemicals that may be out of balance. Premenstrual dysphoric disorder is another condition that sertraline can help with. The antidepressant sertraline is a member of the class of medications known as selective serotonin reuptake inhibitors (SSRIs). Sertraline is used to treat major depressive disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder, and social anxiety disorder (SAD).


Adults: 50 to 200 mg administered once daily is the recommended maintenance dosage range. 50 mg is added once daily after a week of treatment. OCD in children (13 to 17 years old): A starting dose of 50 mg once daily is advised. Children (ages 6 to 12) with OCD: the recommended starting dose is 25 mg once daily. Adults should start with a starting dose of 50 mg once daily for depression or obsessive-compulsive disorder. Adults: A 25 mg once daily starting dose is advised for people with panic disorder, posttraumatic stress disorder, and social anxiety disorder. Adults: A starting dose of 50 mg once daily, either daily throughout the menstrual cycle or during the final two weeks of the cycle, is advised for premenstrual dysphoric disorder. When administered daily throughout the menstrual cycle, the dose may be increased to 150 mg; when administered only during the final two weeks of the cycle, it may be 100 mg. The maximum recommended dose is 200 mg per day.

Missed dose

Never take two doses at once to make up for missed ones. To continue with your regular dosing schedule, skip the missed dose if it is almost time for the next one. As soon as you realize you missed a dose, take it.


Call 911 right away if the victim has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused. In case of overdose, call the poison control helpline at 1-800-222-1222. Additionally, information is accessible online at The following signs of an overdose include: excessive fatigue, dizziness, agitation, mania, seizures, loss of consciousness, drowsiness, agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea.


You should not, however, dispose of this medication in the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication tightly closed in the original container and out of the reach of children. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

Call your doctor if you have any unusual problems while taking this medication. The Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program is available online at or by phone at 1-800-332-1088 if you or your doctor notice a serious side effect. Call your doctor right away if you experience any of the following symptoms or any of those noted in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section: dizziness excessive fatigue headache nervousness uncontrollable shaking of a part of the body sexual problems in men; decreased sex drive, inability to get or maintain an erection, or delay in erection onset. Other adverse reactions to sertraline are possible. Sertraline might have unwanted effects. Discuss the dangers of giving sertraline to your child with their doctor. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Diarrhea constipation vomiting difficulty falling or staying asleep dry mouth heartburn loss of appetite dizziness excessive tiredness headache nervousness uncontrollable shaking of a part of the body sexual problems in men; decreased sex drive, inability to get or maintain an erection, or delayed or absent ejaculation sexual problems in women; decreased sex drive, or delinquent or absent ejaculation Your child's doctor will watch his or her growth carefully.


Prevent St. The John's Wort. With or without food, take.


Ask your pharmacist for a list of the ingredients. tell your doctor if you are taking monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or have stopped taking them within the past 2 weeks, or if you are taking pimozide (Orap). Inform your doctor if you have a latex allergy before taking sertraline liquid concentrate. Inform your doctor and pharmacist if you have any allergies prior to taking sertraline, including those to latex (found in the dropper for the concentrate), other medications, or any of the ingredients in sertraline preparations. Do not take disulfiram (Antabuse) while taking sertraline oral concentrate. Inform your doctor and pharmacist of all prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Wait at least 2 weeks after stopping sertraline before starting an MAO inhibitor. You won't want to take sertraline, your doctor will likely advise.

Is sertraline HCl 50 mg a narcotic?

Since Zoloft is a long-term antidepressant, it is not considered an addictive or narcotic substance. The potential for abuse is low according to psychiatrists, even though it is a mind-altering substance. Taken properly and as prescribed, Zoloft carries very little risk for abuse or addiction.

Is sertraline a strong antidepressant?

Abstract. Sertraline is a selective serotonin reuptake inhibitor (SSRI) with well established antidepressant and anxiolytic activity. Results from several well designed trials show that sertraline (50-200 mg/day) is effective in the treatment of major depressive disorder in elderly patients (> or =60 years of age).

Is sertraline an antidepressant?

Sertraline is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It's often used to treat depression, and also sometimes panic attacks, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).

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Mohamed afiald Mar 20, 2018, 6:55:32 PM

Sertraline has a margin of safety dependent on patient population and/or concomitant medication. Patients randomized to sertraline showed significantly greater improvement than those randomised to placebo on the Children's Yale-Brown Obsessive Compulsive Scale CY-BOCS (p =0.005) the NIMH Global Obsessive Compulsive Scale (p=0.019), and the CGI Improvement (p =0.002) scales. These increased levels were not associated with any changes in EKG. Elderly patients may be at greater risk of developing hyponatraemia with SSRIs and SNRIs. Reporting suspected adverse reactions after authorisation of the medicinal product is important.

user314299 Jan 20, 2022, 8:23:42 PM

If any user is using the liquid form of this medicine, then he or she should mix it with another liquid for consuming it. If an allergy or side-effects happens then immediately report to the doctor. Daxid tablets are consumed once a day as prescribed by the doctor. Do not overdose by taking moredaxid tablets, they can be harmful to the body. The doses of the medication depend on the patient’s health and medical conditions.

k3nd0r Oct 23, 2017, 4:51:36 PM

While using sertraline, patients may notice some improvement in mood and physical symptoms in just a few days. Unfortunately, because Zoloft is one of the most commonly prescribed antidepressants, using it in combination with alcohol with it may be considered to be somewhat routine. Other less common side effects include increased sweating, headaches, insomnia, upset stomach, and diarrhea. Therefore, reducing or avoiding alcohol consumption may be instrumental in allowing the sertraline in your system to work safely and effectively as it is intended. However, the Food and Drug Administration warns against mixing Zoloft and alcohol because both substances affect the neurotransmitters in the brain and, if an unwanted interaction occurs, the individual may suffer a blackout.

Steve Haigh Sep 9, 2013, 5:52:57 AM

Diarrhea Increased sweating Erectile dysfunction Indigestion Insomnia Contact for Sertraline Hydrochloride Tablets Manufacturing And Supply Somacare is one of the leading ISO certified Pharma companies across the country that is offering DCGI & FSSAI approved products to their clients. The company has been very successful in maintaining its goodwill in the Pharma industry despite having so much competition because of the excellent services that we provide to all of our associates till now. We also offer Sertraline Hydrochloride Tablets PCD Pharma Franchise in India. We know the value of precious time, that’s why we deliver every order on time. Zertal-25 is the fusion of Sertraline Hydrochloride Tablets used to treat different mental health-related disorders such as Premenstrual, post-traumatic stress disorder, depression, dysphoric disorder, obsessive-compulsive disorder, panic disorder, anxiety, and Premenstrual syndrome.

neonblitzer Sep 8, 2014, 11:33:40 AM

After four to six weeks, Sertraline helps to attain a steady-state in your body, which means it's fully absorbed and active at a steady dosage every day. In other words, Sertraline cannot get you high. If you experience any suicidal thoughts, consult a doctor immediately. When taken correctly, antidepressants will not change your character.

dawpa2000 May 28, 2011, 1:34:56 AM

Given the rates of mental health, coupled with our prolific media coverage, you probably know someone who is on an SSRI. This in turns feeds positively into your libido and sexual function and confidence. Whenever I start someone on a drug like sertraline, the message is always the same – have patience. This alone has sent the alarm bells ringing, triggering a wave of action from social media campaigns, and the introduction of work mental health first aiders, through to NHS initiatives to improve access to mental health services.

Stephen Graue Aug 24, 2015, 2:57:36 AM

Erectile dysfunction Indigestion Insomnia Diarrhea Increased sweating Contact for Sertraline Tablets Manufacturing And Supply Neurocon Inc. is a leading ISO accredited Pharma Company across the nation that has made its benchmark by offering DCGI & FSSAI approved Pharma drugs at a very nominal rate. The latest kinds of machinery are used by us so that the efficiency of the production process remains as it is. WHO & GMP certified manufacturing facility is used by us to manufacture all of our products. Sertraline Tablets can be taken with or without having a meal but preferably at a fixed time so that a proper amount of medication remains in the body and due consultation should be done with the doctor if suffering from any liver or kidney issues. The shelf life of the products remains intact as we do the packaging process in a very good manner.

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