Side effects
If you experience any strange side effects while taking this medication, contact your doctor right away. Call your doctor right away if you experience any of the following signs: dizziness lightheadedness fainting dry mouth nausea vomiting stomach pain difficulty swallowing heartburn diarrhea gas constipation difficulty falling or staying asleep strange dreams grouchiness depression pain, particularly in the legs or back muscle pain or weakness rash redness, irritation, or sores in the mouth (if you are taking the orally disintegrating tablet). Other negative effects of selegiline may occur. Selegiline may cause side effects. Ask your doctor if you should have your skin checked while receiving treatment, as well as the risks of taking selegiline. If any of these symptoms persist or are severe, consult your doctor right away: dizziness, lightheadedness, fainting, dry mouth, nausea, vomiting, heartburn, diarrhea, gas, constipation, difficulty falling or staying asleep, unusual dreams, sleepiness, depression, pain, particularly in the legs or back, muscle pain or weakness, purple blotches on the skin, rash, redness, irritation, or sores in the mouth (if you are taking the orally disintegrating tablets), etc. There is not enough information to tell whether selegiline or other medications for PD increase the risk of melanoma.
Interactions
Whenever a medical professional treats you, give them a list of all the medications you take. Some medications should not be taken together because they may interact with selegiline. More information on selegiline Adverse reactions Dosage guidance During pregnancy or breastfeeding Reviews (57) Drug images Pricing & coupons Drug class: dopaminergic antiparkinsonism drugs Patient resources Drug Information Selegiline Oral (Advanced Reading) Selegiline Transdermal (Advanced Reading) Selegiline Capsules and Tablets Selegiline Orally Disintegrating Tablets Selegiline Transdermal System Other brands Emsam, Eldepryl, Zelapar Professional resources P This medication guide does not include all interactions that might occur. Drug interactions with selegiline (more information) Inform your physician of all medications you take, as well as any you begin or stop taking while receiving treatment with selegiline. This covers both prescription and non-prescription drugs, vitamins, and herbal products.
Contraindications
Mention any of the following: nafcillin; phenobarbital; phenytoin (Dilantin); selective serotonin reuptake inhibitors like citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); and rifampin (Rifadin, Rimact Tell your doctor and pharmacist if you have any allergies before taking selegiline, including those to other drugs. If you become pregnant while taking selegiline, call your doctor. you should know that selegiline may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. If you stop taking selegiline, your doctor may tell you not to take these medications until at least 14 days have passed since you last took selegiline. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. When you first begin taking selegiline, this happens more frequently. Get out of bed slowly, resting your feet on the floor for a few minutes before standing up, to avoid this issue. If you have phenylketonuria (PKU), an inherited condition that requires a special diet be followed to prevent damage to your brain that can cause severe intellectual disability, you should be aware that the orally disintegrating tablets contain phenylalanine. tell your doctor if you are pregnant, planning a pregnancy, or if you have ever had liver or kidney disease. In the event that you are currently taking or recently took any of these drugs, your doctor might advise against taking selegiline.
Selective serotonin reuptake inhibitors (SSRIs) Serotonin norepinephrine reuptake inhibitors (SNRIs) Tricyclic antidepressants (TCAs) Monoamine oxidase (MOA) inhibitors A class of antidepressants called monoamine oxidase inhibitors or MOAIs doubles blood levels of Zecuity. Concomitant use has been reported to cause prolonged or additive vasospastic reactions. Zecuity should not be used in combination or within 24 hours of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide). Examples of MOAIs include: tranylcypromine (Parnate) phenelzine (Nardil) selegiline (Eldepryl, Carbex, Zelapar) Use of this drug with medications that increase serotonin levels may increase the risk of serotonin syndrome, a rare but serious disorder that may cause symptoms such as: Mental status changes (agitation, confusion, and hallucinations) Sweating High blood pressure Diarrhea Fever Tremor Breathing difficulties Therefore, co-administration with the following classes of antidepressants is not recommended.
Avoid using this remedy if you are under 18 years (there can not be find much information about using Eldepryl by patients yonger 18). In case of monotherapy take5 mg of Eldepryl one or two times daily. Selective inhibitor of MAO-B, which takes part in the metabolism of dopamine and other catecholamines, inhibits the metabolism of dopamine reuptake at the level of its presynaptic terminal. from the sensory organs: diplopia, a violation of visual acuity; from the part of the nervous system: dizziness, hallucinations, fatigue, headache, anxiety, dyskinesia, motor and mental excitement, insomnia, rarely – psychosis, confusion; allergic reactions: photosensitivity, shortness of breath, bronchospasm, skin rash; from the cardiovascular system: orthostatic hypotension, rarely – arrhythmia, increased blood pressure; from the digestive system: increased activity of “liver” of transaminases, constipation or diarrhea, dry mouth, loss of appetite, dysphagia, nausea.
However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Examples of these drugs include: proton pump inhibitors such as: omeprazole esomeprazole H2 receptor antagonists such as: • famotidine Tricyclic antidepressants (TCAs) The combination of amphetamine and a TCA can increase blood pressure and risk of heart problems. An interaction is when a substance changes the way a drug works. Stomach acid drugs When taken with amphetamine, drugs that decrease stomach acid, such as antacids, may increase the level of amphetamine in your body.
Buccal administration of selegiline results in 5-fold higher bioavailability, more reproducible blood concentration, and produces less amphetamine metabolites than the oral tablet form. Due to the presence of these metabolites, people taking selegiline may test positive for "amphetamine" or "methamphetamine" on drug screening tests. While the amphetamine metabolites may contribute to selegiline's ability to inhibit reuptake of the neurotransmitters dopamine and norepinephrine, they have also been associated with orthostatic hypotension and hallucinations. There is some evidence that selegiline acts as a neuroprotectant and reduces the rate of disease progression, though this is disputed.