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safinamide vs selegiline

Selegiline, a monoamine oxidase inhibitor, is used to treat Parkinson's disease and major depressive disorder.

Other names for this medication:
Emsam, Zelapar

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Parkinson's disease and low concentrations of this chemical are related. Selegiline is used together with other medicines to treat symptoms of Parkinson's disease. Selegiline may also be used for purposes not listed in this medication guide. Dopamine (DO pa meen), a chemical found in your brain, is protected from deterioration by selegiline.


-There is no proof that this medication is effective without concurrent levodopa therapy. Tyramine-rich foods should be avoided starting on the first day of therapy at a dose of 9 mg/24 hours or 12 mg/24 hours and should be avoided for a further 2 weeks after these doses are lowered to 6 mg/24 hours or less. Information on Selegiline dosage in detail Oral capsule and tablet: 5 mg orally twice a day taken at breakfast and lunch Maximum dose: 10 mg orally per day Oral disintegrating tablet: 1.25 mg orally once a day for at least 6 weeks -After 6 weeks, the dose may be increased to 2.5 mg orally once a day if necessary Maintenance dose: 1.25 to 2.5 mg orally once a day before breakfast Maximum dose: 2.5 mg orally once a day Comments: -Two to three days after beginning therapy with this Initial dose: 6 mg/24 hours patch applied topically once a day -Based on clinical judgment, doses may be increased in increments of 3 mg/24 hours at intervals of no less than 2 weeks Maintenance dose: 6 mg/24 hours to 12 mg/24 hours patch applied topically once a day Maximum dose: 12 mg/24 hours Comments: -Full antidepressant effect may be delayed. Use: As an adjunct in the management of Parkinson's disease in patients receiving levodopa-carbidopa who show a decline in the quality of their response to this treatment. Major Depressive Disorder (MDD) treatment The typical adult dosage for depression is: Usual Adult Dose for Parkinson's Disease:

Missed dose

To make up for a missed dose, don't take more medication. Skip the missed dose if it is almost time for your next scheduled dose. As soon as you remember, take the missed dose.


If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Symptoms of overdose may include: drowsiness dizziness faintness irritability hyperactivity agitation severe headache hallucinations (seeing things or hearing voices that do not exist) jaw tightness stiffness and arching of the back seizures coma (loss of consciousness for a period of time) fast and irregular pulse chest pain slowed breathing sweating fever cold, clammy skin


Three months after opening the protective pouch, discard any unopened orally disintegrating tablets. You shouldn't flush this medication down the toilet, though. Instead, using a medication take-back program is the best way to get rid of your medication. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Store this medication out of children's reach in the tightly closed, original container. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Keep it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). For information on take-back programs in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city. Always lock safety caps and put medications in a secure location right away that is up and away and out of young children's sight and reach to prevent poisoning. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

If you experience any strange side effects while taking this medication, contact your doctor right away. Call your doctor right away if you experience any of the following signs: dizziness lightheadedness fainting dry mouth nausea vomiting stomach pain difficulty swallowing heartburn diarrhea gas constipation difficulty falling or staying asleep strange dreams grouchiness depression pain, particularly in the legs or back muscle pain or weakness rash redness, irritation, or sores in the mouth (if you are taking the orally disintegrating tablet). Other negative effects of selegiline may occur. Selegiline may cause side effects. Ask your doctor if you should have your skin checked while receiving treatment, as well as the risks of taking selegiline. If any of these symptoms persist or are severe, consult your doctor right away: dizziness, lightheadedness, fainting, dry mouth, nausea, vomiting, heartburn, diarrhea, gas, constipation, difficulty falling or staying asleep, unusual dreams, sleepiness, depression, pain, particularly in the legs or back, muscle pain or weakness, purple blotches on the skin, rash, redness, irritation, or sores in the mouth (if you are taking the orally disintegrating tablets), etc. There is not enough information to tell whether selegiline or other medications for PD increase the risk of melanoma.


Whenever a medical professional treats you, give them a list of all the medications you take. Some medications should not be taken together because they may interact with selegiline. More information on selegiline Adverse reactions Dosage guidance During pregnancy or breastfeeding Reviews (57) Drug images Pricing & coupons Drug class: dopaminergic antiparkinsonism drugs Patient resources Drug Information Selegiline Oral (Advanced Reading) Selegiline Transdermal (Advanced Reading) Selegiline Capsules and Tablets Selegiline Orally Disintegrating Tablets Selegiline Transdermal System Other brands Emsam, Eldepryl, Zelapar Professional resources P This medication guide does not include all interactions that might occur. Drug interactions with selegiline (more information) Inform your physician of all medications you take, as well as any you begin or stop taking while receiving treatment with selegiline. This covers both prescription and non-prescription drugs, vitamins, and herbal products.


Mention any of the following: nafcillin; phenobarbital; phenytoin (Dilantin); selective serotonin reuptake inhibitors like citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); and rifampin (Rifadin, Rimact Tell your doctor and pharmacist if you have any allergies before taking selegiline, including those to other drugs. If you become pregnant while taking selegiline, call your doctor. you should know that selegiline may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. If you stop taking selegiline, your doctor may tell you not to take these medications until at least 14 days have passed since you last took selegiline. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. When you first begin taking selegiline, this happens more frequently. Get out of bed slowly, resting your feet on the floor for a few minutes before standing up, to avoid this issue. If you have phenylketonuria (PKU), an inherited condition that requires a special diet be followed to prevent damage to your brain that can cause severe intellectual disability, you should be aware that the orally disintegrating tablets contain phenylalanine. tell your doctor if you are pregnant, planning a pregnancy, or if you have ever had liver or kidney disease. In the event that you are currently taking or recently took any of these drugs, your doctor might advise against taking selegiline.

What's the difference between selegiline and rasagiline?

Rasagiline is about 10 times more potent in the inhibition of MAO-B than selegiline in ex vivo studies. This higher potency of rasagiline is corrected in the clinic with dose adjustments (approved daily dose 1 and 5–10 mg for rasagiline and selegiline, respectively).

Is selegiline an MAOI?

Selegiline (brand names: Anipryl®, Eldepryl®, l-deprenyl, Selgian®, Zelapar®) is a monoamine oxidase inhibitor (MAOI) used to treat signs due to cognitive dysfunction syndrome in dogs and cats. It has also been used to treat pituitary dependent Cushing's disease, although its effectiveness has not been proven.

Is selegiline an MAOI?

Selegiline (brand names: Anipryl®, Eldepryl®, l-deprenyl, Selgian®, Zelapar®) is a monoamine oxidase inhibitor (MAOI) used to treat signs due to cognitive dysfunction syndrome in dogs and cats. It has also been used to treat pituitary dependent Cushing's disease, although its effectiveness has not been proven.

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Ilya Muradyan Sep 26, 2011, 4:53:00 AM

Selective serotonin reuptake inhibitors (SSRIs) Serotonin norepinephrine reuptake inhibitors (SNRIs) Tricyclic antidepressants (TCAs) Monoamine oxidase (MOA) inhibitors A class of antidepressants called monoamine oxidase inhibitors or MOAIs doubles blood levels of Zecuity. Concomitant use has been reported to cause prolonged or additive vasospastic reactions. Zecuity should not be used in combination or within 24 hours of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide). Examples of MOAIs include: tranylcypromine (Parnate) phenelzine (Nardil) selegiline (Eldepryl, Carbex, Zelapar) Use of this drug with medications that increase serotonin levels may increase the risk of serotonin syndrome, a rare but serious disorder that may cause symptoms such as: Mental status changes (agitation, confusion, and hallucinations) Sweating High blood pressure Diarrhea Fever Tremor Breathing difficulties Therefore, co-administration with the following classes of antidepressants is not recommended.

vimist Dec 14, 2015, 9:45:28 PM

Avoid using this remedy if you are under 18 years (there can not be find much information about using Eldepryl by patients yonger 18). In case of monotherapy take5 mg of Eldepryl one or two times daily. Selective inhibitor of MAO-B, which takes part in the metabolism of dopamine and other catecholamines, inhibits the metabolism of dopamine reuptake at the level of its presynaptic terminal. from the sensory organs: diplopia, a violation of visual acuity; from the part of the nervous system: dizziness, hallucinations, fatigue, headache, anxiety, dyskinesia, motor and mental excitement, insomnia, rarely – psychosis, confusion; allergic reactions: photosensitivity, shortness of breath, bronchospasm, skin rash; from the cardiovascular system: orthostatic hypotension, rarely – arrhythmia, increased blood pressure; from the digestive system: increased activity of “liver” of transaminases, constipation or diarrhea, dry mouth, loss of appetite, dysphagia, nausea.

Mimi Baizura Dec 1, 2016, 3:43:29 AM

However, because drugs interact differently in each person, we can not guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Examples of these drugs include: proton pump inhibitors such as: omeprazole esomeprazole H2 receptor antagonists such as: • famotidine Tricyclic antidepressants (TCAs) The combination of amphetamine and a TCA can increase blood pressure and risk of heart problems. An interaction is when a substance changes the way a drug works. Stomach acid drugs When taken with amphetamine, drugs that decrease stomach acid, such as antacids, may increase the level of amphetamine in your body.

Keeper216 Aug 21, 2013, 7:25:44 AM

Buccal administration of selegiline results in 5-fold higher bioavailability, more reproducible blood concentration, and produces less amphetamine metabolites than the oral tablet form. Due to the presence of these metabolites, people taking selegiline may test positive for "amphetamine" or "methamphetamine" on drug screening tests. While the amphetamine metabolites may contribute to selegiline's ability to inhibit reuptake of the neurotransmitters dopamine and norepinephrine, they have also been associated with orthostatic hypotension and hallucinations. There is some evidence that selegiline acts as a neuroprotectant and reduces the rate of disease progression, though this is disputed.

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