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saxagliptin hydrochloride

It functions by boosting the body's post-meal insulin production when blood sugar levels are high. People with diabetes and high blood sugar over time may develop serious or life-threatening complications, such as heart disease, stroke, kidney issues, nerve damage, and eye issues. A group of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors includes saxagliptin. Saxagliptin is not used to treat diabetic ketoacidosis, a serious condition that can arise if high blood sugar is not treated, or type 1 diabetes, a condition in which the body does not produce insulin and is unable to control the amount of sugar in the blood. Patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally) can lower their blood sugar levels by taking saxagliptin in addition to diet and exercise. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This treatment may also lower your risk of heart attack, stroke, and other diabetes-related complications like kidney failure, nerve damage (resulting in numb, cold legs or feet and decreased sexual ability in both men and women), eye issues, such as changes in vision or loss of vision, and gum disease. The best way to manage your diabetes will be discussed with you by your doctor and other medical professionals.

Other names for this medication:
Kombiglyze, Komboglyze, Onglyza, Qtern, Qternmet

Similar Products:
Amaryl, Januvia, Precose, Glucophage, Glyburide, Glycomet, Glucovance, Acarbose, Glimepiride, Glipizide, Repaglinide, Sitagliptin, Irbesartan


For more details, consult your physician or pharmacist. Saxagliptin is a prescription medication used with diet and exercise to control high blood sugar in adults with type 2 diabetes. This medication may be prescribed for other uses.


Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in a variety of clinical settings. 2.5 or 5 mg orally once daily, regardless of meals. Coadministration with potent CYP450 3A4/5 inhibitors. Comprehensive information on Saxagliptin dosage Diabetes Type 2 Usual Adult Dose:

Missed dose

Do not take a double dose to make up for a missed one unless your doctor tells you that you should. Skip the missed dose and carry on with your regular dosing schedule, though, if it is almost time for the subsequent dose. When you remember, immediately take the missed dose.


Call 1-800-222-1222 for poison help if you need immediate medical attention. Extreme weakness, mental confusion, tremors, sweating, a rapid heartbeat, difficulty speaking, nausea, vomiting, rapid breathing, dizziness, and seizures (convulsions) are a few symptoms of low blood sugar that you may experience.


You should not, however, dispose of this medication in the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Always lock safety caps and immediately stow medication up and away, out of sight, and away from reach of young children to prevent poisoning. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

The following severe side effects are detailed below or elsewhere in the prescribing information: Bullous pemphigoid, Pancreatitis, Heart Failure, Hypoglycemia with Concomitant Use of Sulfonylurea or Insulin, Hypersensitivity Reactions, Severe and Disabling Arthralgia.


Saxagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. However, it is not recommended for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis because it would not be effective in these conditions.


Ask your pharmacist or check the Medication Guide for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Mention any of the following: some antifungal drugs like itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), clarithromycin (Biaxin), some HIV/AIDS drugs like atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and sa Inform your doctor and pharmacist before beginning saxagliptin treatment if you have any allergies to the drug, any other medications, or any of the components found in saxagliptin tablets. Call your doctor if you become pregnant while taking saxagliptin, let them know if you're having surgery, including dental work, and discuss with them what to do if you get hurt or contract an infection or fever. Your blood sugar levels and the amount of saxagliptin you may require may be impacted by these conditions. Tell your doctor if you consume large amounts of alcohol or have ever done so, if you have or have ever had pancreatitis (pancreatic swelling), gallstones, high triglyceride levels in your blood, heart failure, diabetic ketoacidosis, or kidney disease. Also let your doctor know if you are pregnant, intend to become pregnant, or are breastfeeding.

Who should not take Onglyza?

ONGLYZA should not be used to treat people with type 1 diabetes. Have a history of or risk for diabetic ketoacidosis (increased ketones in your blood or urine). ONGLYZA should not be used for the treatment of diabetic ketoacidosis. Have kidney problems.

What is the difference between Januvia and Onglyza?

Side effects of Januvia that are different from Onglyza include back pain, joint or muscle pain, nausea, diarrhea, or constipation. Side effects of Onglyza that are different from Januvia include cough. Both Januvia and Onglyza may interact with other anti-diabetic medications.

What is the best time to take saxagliptin?

You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take saxagliptin before or after a meal.

What are the contraindications of sitagliptin?

Contraindications / Precautions. Sitagliptin is contraindicated in patients with a known sitagliptin hypersensitivity, such as anaphylaxis, urticaria, angioedema, exfoliative dermatitis or other serious skin conditions (serious rash), including Stevens-Johnson syndrome.

What is saxagliptin used for?

Saxagliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors.

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jacktraven Jan 30, 2021, 6:07:51 AM

It was discovered and developed through Phase 1 and Phase 2 by Pfizer. Its metabolism, excretion and pharmacokinetics in rat, dog and human have been described. It is in the class of dipeptidyl peptidase-4 (DPP-4) inhibitors (also called gliptins).

Amirmahdi Feb 22, 2016, 8:53:27 PM

Pancreatitis: Saxagliptin-metformin can cause the pancreas to become inflamed. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Vitamin B12 levels: Metformin may decrease vitamin B12 levels.

user2699113 Mar 21, 2014, 7:03:13 PM

Administration Oral: Administer in the morning with food. Initiation of this combination product is intended for patients who are already on metformin. Otherwise, skip the dose and resume therapy with the next dose taken at the usual time.

shameikmoorey Oct 14, 2019, 4:12:09 PM

A new Warning and Precaution regarding this potential risk has been added to the labels Kombiglyze XR and other drugs in this class. According to the alert, the FDA had identified 33 cases of severe arthralgia reported with the use of DPP-4 inhibitors from October 16, 2006, through December 31, 2013. It was approved by the U.S. Food & Drug Administration (FDA) in November 2010 for the treatment of adults with Type 2 diabetes. U.S. health regulators are currently investigating a potential association between the use of saxagliptin and an increased risk of heart failure. The agency acted after a large clinical trial suggested that patients taking saxagliptin were 27% more likely to be hospitalized as a result of this complication.

Hamza Zubair Aug 27, 2014, 8:02:35 AM

FDA officials also acknowledged a rise in the rate of “all-cause mortality” among study participants who took Onglyza or Kombiglyze XR. Despite record sales throughout the U.S., Onglyza and other DPP-4 inhibitors have dangerous side effects. If you or a loved one suffered heart failure after taking Onglyza or Kombiglyze XR, you may be eligible for financial compensation for your injuries.

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