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Salbutamol
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levosalbutamol vs salbutamol

A beta-2 adrenergic receptor agonist called salbutamol is used to treat conditions like asthma, bronchitis, COPD, and to prevent bronchospasms brought on by exercise.

Other names for this medication:
Combivent, Ventolin, Proair, Airomir, Xopenex, Proventil

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Cyproheptadine, Allegra, Phenergan, Azelastine, Triamcinolone, Astelin, Budecort, Levolin, Asthalin, Combimist

Description

After oral and parenteral administration, stimulation of the beta receptors in the body, both beta-1 and beta-2, occurs because (a) beta-2 selectivity is not absolute, and (b) higher concentrations of salbutamol occur in the regions of these receptors with these modes of administration.,, This results in the beta-1 effect of cardiac stimulation, though not so much as with isoprenaline, and beta-2 effects of peripheral vasodilatation and hypotension, skeletal muscle tremor, and uterine muscle relaxation.,, Metabolic effects such as hyperinsulinemia and hyperglycemia also may occur, although it is not known whether these effects are mediated by beta-1 or beta-2 receptors.,, The serum potassium levels have a tendency to fall. In order to treat asthma and other chronic obstructive pulmonary diseases, bronchodilators such as salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist with structural similarities to terbutaline, are frequently used.,, Levalbuterol, the R-isomer, causes bronchodilation, while the S-isomer increases bronchial reactivity. There may be fewer side-effects when only the R-enantiomer is present because it is readily available and sold as levalbuterol, though this has not been formally proven.

Dosage

If necessary, a higher dosage of up to 5 mg administered four times per day may be used. Salbutamol I.V. infusion solution (1000 mcg/mL) can be diluted in 500 mL of a suitable i.v. solution to create a solution with a salbutamol concentration of 10 mcg/mL that is suitable for infusion. Salbutamol 2.5 mg to 5 mg up to 4 times a day for adults and the elderly. All unused admixtures of Salbutamol infusion solution with infusion fluids should be discarded 24 hours after preparation. Intravenous admixtures, like all parenteral drug products, should be visually examined before administration for clarity, particulate matter, precipitate, discoloration, and leakage. To suggest a dosage schedule for kids, there aren't enough data available right now. Children and Adolescents (<18 years of age): The dosage of Salbutamol infusion solution in the pediatric age group has not been established. Children under 12 years of age: 0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline. Children under 12 years: 2.5 mg up to 4 times a day. Children: One Salbutamol inhalation capsule is the recommended dose for relief of acute bronchospasm in the maintenance of episodic asthma or before exercise in children 4 years of age and older. Excercise-induced Asthma: Adults: 400 microgram Child: 200 microgram, 15-30 minutes prior to any physical exertion. To achieve bronchodilation, 2.0 ml of the solution is infused into the nebulizer and administered to the patient. Two 200 microgram capsules' worth of medication may need to be inhaled every four to six hours for some patients. If necessary, infusion rates can be raised to 10 and 20 mcg/min at intervals of 15 to 30 minutes, starting at 5 mcg of salbutamol/min. Infusion rates that deliver 3 to 20 micrograms of salbutamol per minute (or 0.3 to 2ml of the aforementioned infusion solution per minute) are typically sufficient. Four times per day is possible for intermittent therapy. It shouldn't be injected undiluted. It will take time about 10 minutes. It is not suggested to administer larger doses or more frequently. The maximum single dose is one 8 mg tablet. Adults (and the elderly) should take salbutamol between 0.5 and 1.0 ml up to four times per day using Method 1 (Intermittent Administration). Method 2 (Continuous administration): 1-2 ml of the solution are diluted with 100 ml of sterile saline solution. For routine upkeep or prophylactic therapy, one inhalation should be given three or four times per day. Salbutamol Inhalation Capsule: Adults: For the relief of bronchospasm and for managing intermittent episodes of asthma, one or two inhalation capsule may be administered as a single dose. Under the supervision of a doctor, use salbutamol respiratory solution with a suitable nebulizer device. Adults: Salbutamol injection is used to prepare an intravenous infusion solution that can be continuously administered. Use salbutamol nebulizer solution in accordance with a doctor's prescription and a suitable nebulizer device. For sporadic administration, salbutamol respiratory solution may be used undiluted. Salbutamol tablet or syrup- Children: 2-6 years: 2.5 ml syrup, 3-4 times daily 6-12 years: 5 ml syrup, 3-4 times daily Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily) Adults: 2-4 mg tablet, 3-4 times daily. However, some kids might need higher doses of the solution—up to 1.0 ml. Patients in this situation should be advised to seek medical advice right away rather than increasing their inhaler dosage. A salbutamol inhalation capsule's bronchodilator effect lasts for at least four hours after each administration. A suitable nebulizer device is used to administer the dilute solution. The only diluents that are advised are sodium chloride injection or sodium chloride and dextrose injection. Injection or ingestion of the solution is not permitted. To control recurrent or intermittent episodes of bronchospasm, salbutamol powder for inhalation may be used as prescribed by a physician. Adults should typically take one 200 microgram Salbutamol inhalation capsule every 4 to 6 hours through a device for maintenance or prophylactic therapy. This dosage may be increased to inhalation of two inhalation capsule, if necessary. Typically, this takes 3 to 5 minutes. Under strict medical supervision in the hospital, up to 40 mg/day may be administered. 0.5-1 ml solution should be diluted to a final volume of 2-4 ml with sterile normal saline solution, and up to 40 mg per day can be administered in the hospital under strict medical supervision. When hypoventilation poses a risk for anoxia, oxygen should be added to the inspired air.

Storage

Keep away from light and moisture at a temperature below 30°C. Keep children's reach at a distance.

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Side effects

Salbutamol may cause fine tremor of skeletal muscles (particularly the hands), palpitations and muscle cramps. Large doses have been associated with tachycardia, tenseness, headaches, and peripheral vasodilatation.

Interactions

As a bronchodilator, salbutamol is indicated for use in the treatment of emphysema, chronic bronchitis, asthma, and other conditions characterized by airway obstruction.

Contraindications

Patients with closed angle glaucoma, diabetes mellitus, and those taking antihypertensive medication all require special attention. Increased susceptibility to cardiac arrhythmia brought on by digitalis may result from hypokalaemia brought on by high salbutamol doses. Patients who have hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension, or aneurysms should use salbutamol with caution. With continued use of a high dosage, tachyphylaxis with resistance may develop.

How do you take salbutamol syrup for kids?

Syrup: Adults and Children >12 years: 10-20 mL (salbutamol 2-4 mg); 6-12 years: 10 mL (salbutamol 2 mg); 2-6 years: 5-10 mL (salbutamol 1-2 mg). All doses to be taken 2 or 3 times daily. The volumes of syrup quoted are based on a formulation strength of salbutamol 2 mg/10 mL of syrup.

What is the side effect of Salbutamol tablet?

The most frequent adverse reactions of oral Salbutamol include tremors (particularly the hands), nervousness, headache, dizziness, sleeplessness or insomnia, weakness, drowsiness, restlessness, irritability, tachcardia, palpitation, peripheral vasodilation, flushing, chest discomfort, nausea, dyspepsia, difficulty in ...

What is salbutamol used for?

1. About salbutamol inhalers. Salbutamol is used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing and feeling breathless. It works by relaxing the muscles of the airways into the lungs, which makes it easier to breathe.

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Testimonials
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hodor Jun 9, 2022, 9:33:28 AM

Children aged 12 years and over: Dose as per adult population. After holding their breath for at least 5 seconds the patient can resume normal breathing. Such patients should be warned not to increase their usage of salbutamol, but should seek medical advice in case treatment with an inhaled and/or systemic glucocorticosteroid is indicated.

re1nth Apr 12, 2021, 6:16:40 PM

Salbutamol nebuliser solutions should be discontinued, and if necessary a different fast-acting bronchodilator instituted for on-going use. The dosage or frequency of administration should only be increased on medical advice. It is therefore recommended that patients are monitored for the development of elevated serum lactate and consequent metabolic acidosis in this setting. Diabetic patients may be unable to compensate for the increase in blood glucose and the development of ketoacidosis has been reported. higher doses of inhaled corticosteroid or a course of oral corticosteroid).

FAHMI PRO Feb 15, 2018, 9:21:26 PM

In consideration of this new evidence, the aim of this study was to reanalyze our data from two previous studies to provide further evidence supporting the benefit of the early use of single-dose intravenous bolus salbutamol in children with acute severe exacerbations of asthma. Children with acute severe asthma, if treated effectively in the emergency department (ED), can have the clinical progression of asthma curtailed, resulting in reduced demands placed on EDs and improving the quality of care delivered to acutely sick children. These two studies used what are considered appropriate therapies for childhood asthma: One used a frequent, high-dose nebulized salbutamol alone, and the other used frequent, high-dose nebulized salbutamol in combination with ipratropium bromide.

JusATech Feb 1, 2022, 7:01:00 AM

People also ask Salamol (Salbutamol) belongs to a group of medicines called bronchodilators that work by relaxing the muscles in the walls of the small air passages in the lungs. Like all medicines, this medicine can cause side effects, although not everybody gets them. If the response is inadequate, doses greater than two inhalations can be used.

Pavel Krutikhin Sep 14, 2010, 8:50:26 AM

Poor response to salbutamol can often be attributed to improper use of the delivery device. If you are using salbutamol for an acute asthma episode and the condition continues or worsens, call your doctor or seek medical attention immediately. Never exceed the maximum dosage set by your physician.

Maged Ramez Aug 18, 2018, 9:03:54 AM

If these occur, you need to seek medical help right away to treat the problem. Most of the time, these are relatively minor side effects and will go away after a short while or lessen over time as your body gets used to the drug. Order effective inhalers to manage your asthma View all treatments The most common side effects reported for this drug are tremors, hypersensitivity (to light, usually) and tachycardia (a heart rate that is abnormally high). While these effects may not be as common, you still need to know about them and be prepared to take action should they appear: Swelling in the throat or the mouth Rashes on the skin Redness on the skin Swelling on the hands or genitals Trouble swallowing Confusion Blurred vision Agitation Pain Most of these are considered to be major side effects, and they are potentially very dangerous. While not every side effect is a serious one, you should pay attention to all side effects that you may experience.

user11632 Jan 26, 2012, 7:08:00 PM

It minimally crosses the nasal and gastrointestinal membrane and the blood-brain barrier, resulting in a reduction of the systemic anticholinergic effects (e.g. Salbutamol sulphate, BP (equivalent to Salbutamol)…………… 100 mcg Pressurized metered-dose preparation for inhalation filled in aluminum canister crimped with suitable metered-dose valve, labelled with product label, assembled with polypropylene, adaptor packed in a folding carton along with patient information label. Salbutamol does not appear to be metabolized in the lung, therefore its ultimate metabolism and excretion after inhalation depends upon the delivery method used, which determines the proportion of inhaled salbutamol relative to the proportion inadvertently swallowed. Salbutamol has been given systemically to inhibit preterm labor. However, data on overdose with both drugs are listed below: The signs and symptoms of salbutamol overdose are chest pain, high blood pressure (hypertension) or low blood pressure (hypotension), fast heart rate (tachycardia), nervousness, headaches, shakiness(tremor), dry mouth, feelings of a rapidly or forcefully beating heart (heart palpitations), nausea, dizziness, insomnia, seizures, irregular heart rhythm (arrhythmia), fatigue, low potassium in the blood (hypokalemia) cardiac arrest, loss of life.

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