Description

It was initially created as an independent antiviral agent, but it has been found to work best when combined with other protease inhibitors and low-dose ritonavir. American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) guidelines recommend ritonavir-boosted combination therapies as first-line therapy for HCV Genotype 1a/b and 4 treatment-naïve patients with or without cirrhosis. In order to lower the risk of HIV-1 protease inhibitor drug resistance, all HCV/HIV-1 co-infected patients receiving ritonavir-containing combination therapies should also be taking a suppressive antiretroviral drug regimen. First approved in December 2014, Viekira Pak is indicated for the treatment of HCV genotype 1b without cirrhosis or with compensated cirrhosis, and when combined with Ribavirin for the treatment of HCV genotype 1a without cirrhosis or with compensated cirrhosis. First approved in January 2015, Holkira Pak is indicated for the treatment of HCV genotype 1b with or without cirrhosis, and when combined with Ribavirin for the treatment of HCV genotype 1a with or without cirrhosis. Indicated for the treatment of patients with genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis, Technivie was first approved in July 2015 and is used in conjunction with ribavirin. In Canada, ritonavir is also available as a fixed-dose combination product with , , and as the Health Canada-approved, commercially available product Holkira Pak. It is now more frequently used as a supplement to other protease inhibitors, and it comes in both liquid and capsule forms. Since ritonavir is a strong CYP3A inhibitor, it increases the peak and trough plasma drug concentrations of other protease inhibitors like and overall drug exposure. As well as the FDA- and Health Canada-approved product Technivie, ritonavir is also offered as a fixed-dose combination product. An HIV protease inhibitor called ritonavir prevents HIV from reproducing normally. Ritonavir is present in the FDA-approved drug Viekira Pak, a fixed-dose combination product with,, and. In order to treat coronavirus disease 2019 (COVID-19) in patients who run the risk of developing a severe form of the illness, ritonavir is often combined with other medications. Ritonavir's presence can favor substitutions linked to HIV-1 protease inhibitor resistance. While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster.

Dosage

Ask your doctor or pharmacist for more information. Continue to take ritonavir even if you feel well. Do not split, chew, or crush them. Never stop taking ritonavir without consulting your doctor first. Do not take more or less of it or take it more often than prescribed by your doctor. Use a special spoon rather than a regular household spoon. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow these directions carefully. If you're using the oral solution, measure the precise quantity of liquid required for each dose using a dose measuring spoon, syringe, or cup. If you miss doses, take less than the prescribed dose, or stop taking ritonavir, your condition may become more difficult to treat. If you combine the medication with one of these liquids, you must consume the resulting concoction within an hour of mixing. You may experience more side effects, such as nausea, vomiting, stomach pain, and diarrhea shortly after switching to ritonavir tablets if your doctor instructs you to stop taking the capsule form and start taking the medication instead. It is typically taken with meals twice a day. Ritonavir comes as a capsule, a tablet, and a solution (liquid) to take by mouth. Ritonavir tablets should be consumed whole. Ritonavir should be taken as prescribed. As your body gets used to the tablets, these symptoms may get better. Other prescriptions for this medicine might be given. Keep eating normally unless your doctor advises you otherwise. You can consume the solution on its own or you can enhance the flavor by adding 8 ounces of chocolate milk, Ensure, or Advera brand nutritional supplements. Ritonavir dosages are typically started at low levels and then gradually increased, usually once every two to three days.

Missed dose

Never combine two doses into one. Before you run out of medication entirely, have your prescription filled. If it is almost time for your next dose, skip the missed dose and take the medication as soon as you can.

Overdose

A child may die from an oral liquid ritonavir overdose. Get immediate medical help or dial 1-800-222-1222 for poison help.

Storage

Avoid putting the solution in the refrigerator and allowing it to get too hot or cold. You shouldn't flush this medication down the toilet, though. A medicine take-back program is the preferable method for getting rid of your medication. Ritonavir capsules should be kept in the fridge, but you can also keep them there for up to 30 days. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Store this medication out of children's reach in the tightly closed, original container. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. At room temperature, keep the tablets and solution. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Always lock safety caps and immediately store medications up and away and out of young children's sight and reach. http://www.upandaway.org Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot ingest them.

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Side effects

If you experience any unusual issues while taking this medication, contact your doctor right away. Call your doctor right away or seek emergency medical attention if you experience any of the following symptoms: drowsiness, diarrhea, gas, heartburn, change in food taste, headache, numbness, burning, or tingling in the hands, feet, or region around the mouth, blistering or peeling skin, rash, hives, swelling of the eyes, face, tongue, lips, or throat, tightening of the throat. Ritonavir may cause other side effects. Ritonavir may have negative effects. Tell your doctor if any of these symptoms are severe or do not go away: drowsiness diarrhea gas heartburn change in ability to taste food headache numbness, burning, or tingling of the hands, feet, or area around the mouth muscle or joint pain stomach pain, nausea, and vomiting blistering or peeling of the skin rash hives swelling of the eyes, face, tongue, lips, or throat tightening of the throat difficulty breathing or swallowing nausea vomiting stomach pain excessive tiredness lack of energy loss of appetite pain in the upper right part of the stomach yellowing of the skin or eyes dizziness lightheadedness loss of consciousness irregular heartbeat Some side effects can be serious.

Interactions

Tell your doctor right away if you're taking both saquinavir and rifampin. Tell your doctor right away if you're taking rifampin. Discuss potential drug interactions and side effects with your doctor before taking ritonavir with Viagra, Cialis, or Levitra. Do not take ritonavir with the cholesterol-lowering medicines Mevacor (lovastatin) or Zocor (simvastatin) because of possible serious reactions. The following medications should not be taken with ritonavir because they may result in serious or life-threatening issues like irregular heartbeat, breathing issues, or excessive sleepiness: Halcion (triazolam), Hismanal (astemizole), Orap (pimozide), Propulsid (cisapride), Quinidine, also known as Quinaglute, Cardioquin, Quinidex, and other medications Ergotamine, ergonovine, methylergonovine You should seek medical attention right away if an erection lasts more than four hours to prevent permanent penile damage. If you are taking AdcircaTM (tadalafil) for pulmonary arterial hypertension, your doctor may change your dose of this medicine. If you are taking Colcrys (colchicine), your doctor will tell you what dose to use. Your doctor will reduce the dosage of Mycobutin (rifabutin) if you are taking it. Since ritonavir may lessen the effectiveness of oral or patch contraceptives, you should use a different method of contraception if you are currently using either of them to prevent pregnancy. The recommended dosage for Tracleer (bosentan) will be provided by your doctor. When taking didanosine (Videx) and ritonavir together, there should be a minimum gap of 2.5 hours between the two medications. Consult your doctor about potential side effects that Advair (salmeterol plus fluticasone propionate) and ritonavir may have when used together if you are currently taking either medication or plan to do so soon. Consult your doctor about any potential issues these medications may cause when used together if you are currently taking Serevent (salmeterol) or plan to do so soon. Consult your doctor if you are using inhaled Flonase (fluticasone propionate) or if you plan to use it for the first time about any potential side effects. You run the risk of experiencing adverse effects like low blood pressure, vision changes, and penile erections lasting longer than four hours if you combine these drugs with ritonavir. When you take ritonavir along with other medications, it's possible that your doctor will need to adjust the dosage of those drugs. St. John's wort (hypericum perforatum), a herbal supplement or merchandise containing St. The use of John's wort may lower ritonavir levels, increase viral loads, and increase the risk of developing ritonavir resistance or cross-resistance to other antiretroviral drugs. Jesus' wort Additionally, the oral solution of ritonavir contains alcohol. Recall to discuss all medications you are currently taking or intend to take with your doctor. Ritonavir should not be taken with rifampin or saquinavir. Rifampin, also referred to by the names Rimactane, Rifadin, Rifater, or Rifamate, may lower ritonavir levels in the blood. Other medications, including those you take without a prescription, may interact with ritonavir. You might experience severe nausea and vomiting. By using St. If you take St. Consult your doctor if you intend to take St. If you are currently taking metronidazole or disulfiram, or if you plan to start soon, discuss this with your doctor. The following medicines require dose reduction if taken with ritonavir: If you are taking PDE5 inhibitors for erectile dysfunction including Viagra (sildenafil), Cialis (tadalafil), or Levitra (vardenafil), your doctor may lower your dose of these medications. Talk to your doctor before taking any of these cholesterol-lowering medications with ritonavir because there is an increased risk of drug interactions between ritonavir and Lipitor (atorvastatin). You must tell your doctor about all the medicines you are taking or are planning to take. If you are taking ritonavir to treat pulmonary arterial hypertension, you shouldn't combine it with sildenafil (Revatio). Your doctor can explain these symptoms to you. Your doctor may decide not to keep you on Advair, which contains salmeterol and fluticasone propionate. Serevent (salmeterol) may not be prescribed to you by your doctor. Your doctor might decide not to keep you on inhaled Flonase.

Contraindications

You must inform your doctor of all the medications you are currently taking or intend to take before taking ritonavir. If you are taking certain medications, you should not take ritonavir. In the event that you have ever experienced a severe allergic reaction to ritonavir or any of its components, you should not take it. These could have fatal side effects. These consist of additional prescription and over-the-counter medications as well as herbal supplements. Together with your doctor, you need to decide whether ritonavir is right for you.

Who makes generic ritonavir?

Ritonavir is an antiretroviral medication used along with other medications for the treatment of human immunodeficiency virus (HIV-1) infection. Hikma's ritonavir tablets are the first AB-rated generic to AbbVie's brand-name product Norvir (ritonavir) tablets.

What is ritonavir tablet?

Ritonavir (brand name: Norvir) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children older than 1 month. Ritonavir is always used in combination with other HIV medicines.

What is ritonavir medicine used for?

Descriptions. Ritonavir is used together with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Ritonavir will not cure or prevent HIV infection or AIDS.

Can you take ritonavir with simvastatin?

Using simvastatin together with ritonavir is not recommended. Combining these medications may significantly increase the blood levels of simvastatin.

What is ritonavir pills used for?

Descriptions. Ritonavir is used together with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Ritonavir will not cure or prevent HIV infection or AIDS.

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