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risperidone contraindications

Boxed warning for increased mortality risk in elderly patients with dementia-related psychosis is present with all antipsychotics. Atypical antipsychotics of the benzisoxazole class that are administered orally and parenterally For adults with schizophrenia and bipolar I disorder, it is administered orally and intramuscularly as an extended-release (ER) injection; for adults with schizophrenia, it is administered subcutaneously; for a small number of pediatric patients, it is administered orally for irritability linked to autism spectrum disorder.

Other names for this medication:
Risperdal, Perseris

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The main active metabolite of risperidone, 9-hydroxyrisperidone, is another widely used SGA. Risperidone has a much higher affinity for binding to 5-HT2A receptors than it does for D2 receptors, which is why some of its negative side effects may be attributable to this. A second-generation antipsychotic (SGA) drug called risperidone is used to treat schizophrenia and bipolar disorder, among other mood and mental health conditions. Risperidone is thought to lessen this overactivity by blocking serotonergic 5-HT2A receptors and dopaminergic D2 receptors in the brain. Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively.


Information about Risperidone dosage in detail Do not freeze liquid medications. Do not mix the liquid medicine with cola or tea. Read all medication guides or instruction sheets and adhere to all instructions on your prescription label. Your symptoms might not start to get better for a few weeks. If your symptoms do not subside, continue taking the medication as prescribed and contact your doctor. Carefully titrate any liquid medications. In your mouth, without chewing, place the tablet, and let it dissolve. Only take an oral disintegrating tablet out of the packaging when you are prepared to take the medication. With or without food, risperidone can be taken. Keep at room temperature and away from heat, light, and moisture. Swallow several times as the tablet dissolves. Follow your doctor's instructions for taking risperidone precisely. Use a medicine dose measuring device (not a kitchen spoon) or the dosing syringe that is provided.

Missed dose

To make up for a missed dose, don't take a second one. If the next dose is almost due, skip the missed one and carry on with your regular dosing schedule. As soon as you remember, take the missed dose.


However, if overdose is thought to have occurred, get emergency medical help. An overdose is unlikely to happen if this medication is administered by a healthcare professional in a hospital setting. If you take too much of this medication, call your doctor or the nearest poison control center right away or go to the hospital for emergency care.


Consult your pharmacist or the neighborhood waste management company. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. The liquid form of this medication should not be frozen. Store away from bathrooms. Away from children and pets, keep all medications. When the product has run its course or is no longer required, properly dispose of it. Store in a dark, dry place away from light and moisture.

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Side effects

If you experience any of the following: For medical guidance on side effects, contact your doctor. Common risperidone side effects may include: If you experience any of the following symptoms of a risperidone allergy: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, seek emergency medical attention. Risperidone side effects (more information) There may be additional side effects; this is not a comprehensive list. Call 1-800-FDA-1088 to contact FDA and report side effects. headache; lightheadedness, drowsiness, or fatigue; trembling, twitching, or uncontrollable muscle movements; agitation, anxiety, or restlessness; melancholy; weight gain; or cold-related symptoms like runny nose, sneezing, or sore throat. severe nervous system reaction: very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out; low white blood cells: sudden weakness or ill feeling, fever, and uncontrollable facial muscle movements; impotence; lack of interest in sex; missed menstrual periods; uncontrollable facial movements; breast swelling or tenderness (in men or women); nipple discharge; impotence; severe nervous


Before taking an opioid prescription, a sleeping aid, a muscle relaxant, or a seizure or anxiety medication, consult your doctor. These interactions between drugs are not exhaustive. Other drugs may interact with risperidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Drug interactions involving ripiprazole (more information) Risperidone can have adverse effects that are harmful or even fatal if combined with other medications that cause drowsiness or slow breathing. Inform your doctor of all other medications you are taking, especially: This is not a complete list. Levodopa, fluoxetine (Prozac) or paroxetine (Paxil), carbamazepine, clozapine, or other antipsychotic drugs.


You might feel more groggy or faint if you drink alcohol or use marijuana (cannabis). Avoid alcoholic beverages. Avoid activities that could make you overheat, such as strenuous exercise in the heat or hard work, as well as using hot tubs. Babies born to mothers who used this medication during the last three months of their pregnancy may sporadically experience symptoms like muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or unceasing crying. Tell your doctor or dentist if you are currently taking this medication or have ever taken it, as well as about all other products you use, including prescription medications, over-the-counter medicines, and herbal remedies, before having surgery (including cataract/glaucoma eye surgery). Inform your doctor or pharmacist if you have any allergies before taking risperidone, paliperidone, or any other medications. Before using risperidone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). If you have any of the following medical conditions prior to taking this medication, be sure to mention them to your doctor or pharmacist: liver disease, kidney disease, seizures, difficulty swallowing, low white blood cell count, Parkinson's disease, dementia, certain eye conditions (cataracts, glaucoma), personal or family history of diabetes, heart disease, high cholesterol/triglyceride levels, and breathing issues during sleep (sleep apnea). Prior to breastfeeding, consult your doctor. Until you can do something safely, avoid operating machinery, driving, or doing anything else that requires alertness. Falling is more likely when you're sleepy, queasy, or lightheaded. During pregnancy, this medication should be used only when clearly needed. Immediately seek medical attention if you experience a fever that won't go away, mental or mood changes, a headache, or dizziness. Discuss the advantages and disadvantages of using this medication during pregnancy with your doctor as soon as you become pregnant, plan to become pregnant, or suspect that you may be pregnant. Inform the doctor as soon as possible if you notice any of these symptoms in your newborn, especially during the first month. Find a place to cool off and rest right away if you start to sweat. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, lightheadedness, and QT prolongation (see above). Rarely, QT prolongation can result in fast/irregular heartbeat that is serious (rarely fatal) and other symptoms like severe dizziness and fainting that require immediate medical attention. Risperidone may cause a condition that affects the heart rhythm (QT prolongation). Since untreated mental/mood problems (such as schizophrenia, bipolar disorder, depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. Talk to your doctor about using risperidone safely. If you use marijuana (cannabis), consult your physician. Get more information by speaking with your pharmacist. If your baby experiences symptoms like trembling or stiffness in the muscles, excessive sleepiness, or trouble feeding, call the doctor right away. If you have certain medical conditions or are taking other medications that may prolong QT, your risk of QT prolongation may increase. You might feel lightheaded or sleepy after taking this medication. Your likelihood of suffering from heat stroke may increase if this medication causes you to sweat less. This medication enters breast milk and could negatively impact a nursing infant. This product may contain inactive ingredients, which can cause allergic reactions or other problems. This risk may rise if you take specific medications (such as diuretics or "water pills") or experience certain health issues, such as excessive sweating, diarrhea, or vomiting. Be sure to stay hydrated and wear light clothing when the weather is hot.

Is risperidone a powerful drug?

Risperdal (risperidone) is a powerful second generation antipsychotic initially approved for the treatment of schizophrenia in adults and adolescents.

How will it make me feel?

You may find risperidone makes you: feel calmer and less upset able to concentrate better and think more clearly able to get things done and stay focussed more aware of what may and may not be real stop hearing voices remember things more easily feel more comfortable with other people and get along better with them

Is there any food or drink I need to avoid?

Apart from limiting alcohol, you can eat and drink normally while taking risperidone. However, risperidone can make you feel hungrier and put on weight. If you have an increased appetite, try to eat a healthy balanced diet without increasing your portion sizes. Do not snack on foods that contain a lot of calories, such as crisps, cakes, biscuits and sweets. If you feel hungry between meals, eat fruit and vegetables and low-calorie foods.

Can risperidone be given by injection?

Risperidone is injected under the skin or into a muscle. A healthcare provider will give you this injection. Risperdal Consta is usually given once every 2 weeks.

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Iskandar Najmuddin May 13, 2014, 8:03:05 PM

Study authors reviewed data on over 75,400 elderly residents in nursing homes located in 45 states across the country. The atypical antipsychotic medication is not approved by the U.S. Food and Drug Administration (FDA) for the management of behavior problems in older adults with dementia. He also shared how they have received a lot of regulatory attention for the adverse events associated with antipsychotics. Although several studies have indicated that there’s less possibility for newer second-generation antipsychotics to cause extrapyramidal symptoms (EPS) compared to conventional antipsychotics, this doesn’t mean that the newer ones don’t come with risks.

MariaTerror Dec 12, 2011, 8:19:45 PM

The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves. Risperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. Nerves communicate with each other by making and releasing chemicals called neurotransmitters.

Anuj Dinesh Singh Sep 19, 2013, 12:45:54 PM

In adults and children above 13 years, Risperidone is used for the treatment of Schizophrenia. In children between 5 to 16 years the drug is used for the treatment of irritability due to autism. Risperidone is used in various age groups for the management of various brain-related disorders. Risperidone is a second-generation antipsychotic used to treat schizophrenia, bipolar mania, and severe depression. Risperidone is a Schedule 8 drug and hence will be sold only after producing a prescription from a registered medical practitioner.

user3447259 Nov 20, 2022, 3:32:28 PM

Patients with renal impairment have less ability to eliminate the active antipsychotic fraction than in adults with normal renal function. As with all symptomatic treatments, the continued use of Risperidone tablets must be evaluated and justified on an ongoing basis. The dosage may be increased on the second day to 4 mg. Risperidone tablets may be given once daily or twice daily.

Dagrol Sep 25, 2010, 4:56:00 AM

A patient developed facial and periorbital oedema 2 weeks after her dose of risperidone reached 6 mg daily. Risperidone is described as an atypical antipsychotic although it has a lower propensity to produce parkinsonism, dys-tonias and akathisias have been reported. Dystonia and worsening of tremors were reported 1 week after adding indinavir and ritonavir to treatment with risperidone in a patient with AIDS he recovered once all 3 drugs were withdrawn and following treatment with clonazepam. It is given orally for the treatment of schizophrenia and other psychoses and in the short-term treatment of acute manic or mixed episodes associated with bipolar disorder.

P Mishra Aug 25, 2021, 6:38:32 AM

This information is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Researchers believe that it triggers a hormone imbalance in adolescent and young adult males that causes them to grow large breasts. In the case of risperidone, studies show that its half-life for poor metabolizers is 20 hours, while for extensive metabolizers it may only take 3 hours for the chemicals from the medicine to leave the system. Always talk to your healthcare provider about potential adverse effects and seek immediate medical attention if you experience serious side effects.

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