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Ribavirin
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ribavirin 200 mg

Maintain all scheduled times with your physician and the lab. Ribavirin treats chronic hepatitis C and Respiratory Syncytial Virus (RSV). To keep an eye on you, your doctor will request blood tests.

Other names for this medication:
Ibavyr, Rebetol, Virazole

Similar Products:
Atripla, Lopinavir, Emtricitabine, Daclatasvir, Truvada, Tenofovir, Viraday, Kaletra, Sovaldi, Ledipasvir, Ritonavir, Tenvir, Sustiva, Harvoni, Sofosbuvir, Efavirenz

Description

It belongs to the class of medications known as nucleoside antimetabolites that prevent viral genetic material from being duplicated. By increasing the frequency of mutations in the genomes of several RNA viruses, ribavirin mediates direct antiviral activity against several DNA and RNA viruses. Due to its similarity to the components of RNA molecules, the drug inhibits the activity of the enzyme RNA dependent RNA polymerase.

Dosage

While taking this medication, be sure to get regular dental exams. Information on how to take Ribavirin in full Drink extra fluids while you are taking ribavirin to keep from getting dehydrated. Read all medication guides or instruction sheets and adhere to all directions on your prescription label. To avoid harming your teeth or gums, rinse your mouth out with water if you vomit while taking ribavirin. Carefully titrate any liquid medications. Dry mouth brought on by ribavirin may result in gum disease or tooth decay. As a stand-alone treatment for hepatitis C, ribavirin is ineffective and must be taken in combination with other drugs. Store ribavirin liquid (oral solution) at room temperature or in the refrigerator. Away from moisture, heat, and light, keep ribavirin tablets or capsules at room temperature. Do not chew, break, chew, or open the capsule; instead, swallow it whole. To take ribavirin, eat something. Tell your doctor if you have trouble swallowing the capsule. Use a medicine dose-measuring device (not a kitchen spoon) or the dosing syringe that is provided. Follow the medication's instructions exactly. Medical examinations will be required frequently.

Missed dose

Never take two doses at once. Before you run out of medication entirely, have your prescription filled. If your next dose is approaching, skip the missed dose. On the day that you recall missing the dose, take it.

Overdose

If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help.

Storage

This medication should not, however, be flushed down the toilet. The best way to get rid of your medication is instead through a medication take-back program. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Keep this medication tightly closed in its original container away from the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Ribavirin oral solution should be kept either in the refrigerator or at room temperature. Store ribavirin tablets and capsules at room temperature and away from excess heat and moisture (not in the bathroom). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Always lock safety caps and put medication in a secure spot right away that is up and out of the way and out of reach of young children to prevent poisoning. http://www.upandaway.org Unused medications must be disposed of carefully to prevent pets, kids, and other people from ingesting them.

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Side effects

In the event that you experience: For medical guidance on side effects, contact your doctor. Typical negative effects could be: If you experience chest pain, call for emergency assistance. If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat, seek emergency medical attention. Rarely, this may result in life-threatening heart issues. Children's growth may be harmed by ribavirin. Anemia may be induced by ribavirin. consequences of ribavirin (more information) Tell your doctor if your child is not growing at a normal rate while using this medicine. This is not a complete list of side effects and others may occur. You can contact the FDA to report side effects at 1-800-FDA-1088. nausea, vomiting, loss of appetite; fever, chills or shaking; low blood cell counts, anemia; feeling weak or tired; headache, muscle pain; or mood changes, feeling anxious or irritable. vision issues; excruciating upper abdominal pain that radiates to your back; nausea, vomiting, and diarrhea; a new or worsening cough; fever; sharp chest pain; wheezing; and shortness of breath. Severe depression, suicidal or self-destructive thoughts; pale or yellowed skin; dark urine; confusion; or other symptoms of low blood cell counts, such as fever, chills, flu-like symptoms, swollen gums, mouth sores; and

Interactions

Steer clear of alcohol. Ribavirin is used to treat chronic hepatitis C infection; consuming alcohol may make this infection worse. When taking, eat. When taken with a high-fat meal, ribavirin's absorption is slowed and its AUC and Cmax are elevated.

Contraindications

Additionally, a pregnancy test should be performed each month while taking this medication and for six months after stopping it. Alcohol or marijuana (cannabis) can make you more dizzy. Steer clear of alcoholic beverages. Breastfeeding is not advised while taking this medication due to the potential risk to the infant. Inform your doctor or pharmacist if you are allergic to ribavirin or if you have any other allergies before taking it. In particular, mention any blood disorders (such as sickle cell anemia, low hemoglobin, or thalassemia), kidney disease, other liver problems (such as autoimmune hepatitis), heart disease, high blood pressure, breathing issues, pancreas problems (such as pancreatitis), or diabetes to your doctor or pharmacist before using this medication. Until you can do something safely, avoid operating machinery, driving, or doing anything else that requires alertness or sharp vision. When taking this medication, elderly patients may be more susceptible to anemia. Inform your doctor right away if you become pregnant or suspect you might be pregnant. Whether this medication enters breast milk is unknown. It is recommended that female patients or female partners of male patients take a pregnancy test before starting this medication. With age, kidney function decreases. Ribavirin must not be used during pregnancy. Observe the Warning section as well. If you use marijuana (cannabis), consult your physician. Talk to your pharmacist for more details. This medication may cause you to feel lightheaded or cause vision blur. This medication is removed by the kidneys. Inactive ingredients in this product have the potential to cause allergic reactions or other issues.

Why ribavirin is used?

Ribavirin is used with an interferon medication such as peginterferon alfa-2a [Pegasys] or peginterferon alpha-2b [PEG-Intron]) to treat hepatitis C in people who have not been treated with an interferon before. Ribavirin is in a class of antiviral medications called nucleoside analogues.

Is ribavirin a direct-acting antiviral?

Ribavirin revisited in the era of direct-acting antiviral therapy for hepatitis C virus infection.

Is ribavirin still used for hep C?

The use of ribavirin with interferon or peginterferon for the treatment of hepatitis C is no longer recommended due to the poor efficacy and high rate of adverse effects with this regimen. Currently, still plays a role on a limited basis in combination with some direct-acting antiviral agents and combinations.

Who manufactures ribavirin?

Ribavirin is a synthetic nucleoside analogue with antiviral activity currently marketed by Roche Pharmaceuticals under the brand name Copegus(R). Annual U.S. sales of the product are approximately $200 million.

How does ribavirin help fight viral infections?

Ribavirin mediates direct antiviral activity against a number of DNA and RNA viruses by increasing the mutation frequency in the genomes of several RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of the viral genetic material.

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Testimonials
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LEON83 May 27, 2018, 6:02:25 AM

Ribavirin ( Copegus , Rebetol , Ribasphere , Ribatab , RibaPak , Virazole , CHNO, MW 244.20) occurs as a white, crystalline powder that is freely soluble in water (142 mg/mL at 25°C) and slightly soluble in dehydrated alcohol. Sterile Water for Inhalation, USP, is prepared from Water for Injection, USP, that is sterilized and suitably packaged. Use: This preparation has been used to treat respiratory syncytial virus infection in hospitalized infants and young children. Dissolve the ribavirin and sodium chloride in sufficient Sterile Water for Injection or Sterile Water for Inhalation to final volume and mix well.

sousatg Apr 28, 2012, 1:20:54 PM

If the starting dose is not well tolerated, the dose should be reduced as clinically indicated based on haemoglobin levels * If a more normalized dose of ribavirin (by weight and renal function) cannot be reached for reasons of tolerability, 24 weeks of Harvoni + ribavirin should be considered in order to minimize the risk for relapse. Patients with decompensated cirrhosis irrespective of transplant status Harvoni + ribavirin for 12 weeks (see section 5.1) - Harvoni (without ribavirin) for 24 weeks may be considered in patients who are ineligible for or intolerant to ribavirin. Harvoni treatment should be initiated and monitored by a physician experienced in the management of patients with CHC. No dose adjustment is warranted for elderly patients (see section 5.2). However, it is not recommended that ribavirin be increased to the originally assigned dose (1,000 mg to 1,200 mg daily).

user3820296 Sep 17, 2013, 8:15:32 PM

In adults a starting ribavirin dose of 400 mg administered orally in two divided doses with food is recommended. No dose adjustment of Sovaldi is required for patients with mild or moderate renal impairment. If it is after 18 hours then patients should be instructed to wait and take the next dose at the usual time.

HIMANSHU SINGHAL Apr 6, 2014, 7:52:25 PM

Additionally, many of the patients had other difficult-to-treat indices, including cirrhosis (6–9%), high viral load (90%), and African-American ancestry (14–17%). The second group received boceprevir plus peginterferon-ribavirin for 32 weeks, and those with a detectable HCV RNA level at week 8 received peginterferon-ribavirin and placebo for another 12 weeks. It occurred in half of the patients who received boceprevir and by about a third of the patients taking peginterferon alfa-2b plus ribavirin at the standard dose. All patients received a month of peginterferon alfa-2b and ribavirin before being randomized to one of three arms.

Sakamaki Izayoi Mar 2, 2021, 12:39:21 AM

This may worsen your condition and can lead to a possibly fatal heart attack. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to treat severe acute respiratory syndrome (SARS). Doing so will decrease the risk of serious side effects. Women and men who are taking ribavirin must avoid pregnancy by using two forms of reliable birth control (such as latex condoms and birth control pills) during treatment with this drug and for 6 months after this medication has been stopped.

DaRkWoMaN Mar 3, 2018, 11:56:07 AM

Some side effects associated with this treatment include fatigue, headache, nausea, insomnia, and anemia (low red blood cells). There are 6 HCV genotypes (genotype 1-6); genotype 1 is the most prevalent in the United States. In clinical trials, Incivek + ribavirin + peglyated interferon produced SVR in 61.9% to 77.9% of patients.

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