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pyridostigmine side effects

Pyridostigmine is a cholinesterase inhibitor used to treat the symptoms of congenital myasthenic syndromes, myasthenia gravis, and to undo the neuromuscular blockade caused by nondepolarizing muscle relaxants.

Other names for this medication:
Regonol, Mestinon

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Synthroid, Methylprednisolone, Dostinex, Medrol


Acetylcholinesterase inhibitors have been the symptomatic treatment of choice in myasthenia gravis since the 1930s with the early use of and. By inhibiting the breakdown of acetylcholine in the neuromuscular junction, they increase signalling and relieve symptoms.,, Pyridostigmine is the current drug of choice, with superior pharmacokinetics and reduced side effects compared to., In addition to treating myasthenia gravis, pyridostigmine is used to reverse neuromuscular blocks, relieve symptoms in congenital myasthenic syndromes, and protect against certain nerve agents, notably during the Gulf War.,,, Autoantibodies against the acetylcholine receptor (AChR) are the most common cause of the neuromuscular junction dysfunction in myasthenia gravis, which causes fatigue, loss of muscle tone, and muscle weakness. Extended-release tablets, syrups, and injections, sold under different brand and generic names, have now been added to the list of possible dose forms. Pyridostigmine was granted initial FDA approval on April 6, 1955, as an oral tablet.


Carefully follow your doctor's instructions about how much medicine to take and when to take it. Information on the correct dosage of pyridostigmine. Do not crush, chew, or break an extended-release tablet. Never take this medication in excess of what is advised or for an extended period of time. Observe every instruction on your prescription label. Ask your pharmacist for a dose-measuring device if you don't have one already. If you need surgery, tell the surgeon ahead of time that you are using pyridostigmine. Together with the canister of moisture-absorbing preservative that comes with this medication, keep the tablets in their original container. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Away from heat and moisture, store items at room temperature. Totally inhale it. If this medication upsets your stomach, take it with food or milk. The timing and dosage of this medication are crucial for the effectiveness of your treatment. This will help your doctor determine if your dose needs to be adjusted. You might be required to keep a daily log detailing when you took each dose and how long the effects lasted. You might need to temporarily stop taking the medication. To ensure you receive the best results, your doctor may occasionally adjust your dose.

Missed dose

To make up for a missed dose, don't take more medication. If it is almost time for your next scheduled dose, skip the missed dose. The missed dose should be taken as soon as you remember.


Overdose symptoms may include nausea, vomiting, diarrhea, stomach cramps, sweating, blurred vision, drooling, and weak or shallow breathing. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Your myasthenia gravis symptoms staying the same or getting worse could also be signs of an overdose.


You shouldn't flush this medication down the toilet, though. Instead, utilizing a medicine take-back program is the best way to get rid of your medication. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication out of the reach of children and tightly closed in the original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. For information on take-back programs in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

For medical advice about side effects, contact your doctor. Typical negative effects may include: If you experience any of the following symptoms of an allergic reaction, seek emergency medical attention right away: hives; trouble breathing; swelling of your face, lips, tongue, or throat. Effects of pyridostigmine (more information) If you experience any of these severe side effects from pyridostigmine, stop using it immediately and call your doctor. This is not a complete list of side effects and others may occur. You can contact the FDA to report side effects at 1-800-FDA-1088. Extreme muscle weakness, loss of movement in any part of your body, shallow or weak breathing, slurred speech, vision issues, or worsening or stagnation of myasthenia gravis symptoms are all possible symptoms. stomach aches, nausea, vomiting, diarrhea, twitching muscles, sweating, increased salivation, mucusy coughs, rash, or blurred vision.


Irritation is reduced by food. Take this medication with food.


Ask your pharmacist or look in the patient information for a list of the ingredients. If you have an allergy to pyridostigmine, bromides, any other medications, or any of the ingredients in pyridostigmine preparations, tell your doctor and pharmacist before taking pyridostigmine. Remember that alcohol can exacerbate the drowsiness brought on by this drug, so don't drive or operate machinery until you know how it affects you. Call your doctor if you become pregnant while taking pyridostigmine because it can cause drowsiness.

What is pyridostigmine an antidote for?

Pyridostigmine bromide is indicated for prophylaxis against the lethal effects of soman nerve agent poisoning. Pyridostigmine is intended to be used in conjunction with protective garments, including a gas mask, and immediate atropine and pralidoxime therapy at the first sign of nerve agent poisoning.

Is pyridostigmine bromide a steroid?

Pyridostigmine (Mestinon) is not a steroid (or corticosteroid). It is an acetylcholinesterase inhibitor, so it works very differently from steroids.

How do you take pyridostigmine?

The tablets should be taken with water. If you have difficulty swallowing, the tablets can be broken into pieces. You should take the medicine so that it can work when your muscles are needed most. For example when you get up and about 30 to 60 minutes before a meal.

What kind of medication is pyridostigmine?

Mestinon (pyridostigmine) is a cholinesterase inhibitor used to treat the symptoms of myasthenia gravis. Mestinon is also used in military personnel who have been exposed to nerve gas. Mestinon is available in generic form.

Can you drink alcohol with pyridostigmine bromide?

It is safe to drink alcohol in moderation whilst taking pyridostigmine.

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user180847 Jul 2, 2013, 3:42:32 AM

• The most common shorthand of "Convulsive Antidote, Nerve Agent" is CANA. What is the abbreviation for Convulsive Antidote, Nerve Agent? • CANA stands for "Convulsive Antidote, Nerve Agent". How to abbreviate "Convulsive Antidote, Nerve Agent"?

user119428 Mar 19, 2018, 4:22:20 PM

It should be noted that the slower gastro-intestinal motility caused by these drugs may affect the absorption of pyridostigmine bromide. Pyridostigmine antagonises the effect of non-depolarising muscle relaxants (e.g. Methylcellulose and medicine containing methylcellulose as excipients can completely inhibit absorption of pyridostigmine bromide.

Andrei Rizea Jun 28, 2012, 2:37:36 PM

تنويه: سعر الدواء يختلف باختلاف الدولة والتوقيت؛ فقد ترى اختلافًا في الأسعار بمرور الوقت أو في بلدٍ مختلف. يراعي توخي الحذر عند إستخدام الأتروبين للتغلب على الأعراض الجانبية. الحمل: • فاعلية وأمان إستخدام بيريدوستيجمين أثناء الحمل والرضاعة للإنسان غير متفق عليها وبالتالى فإن إستخدام العقار للسيدات الحوامل أو اللاتي يمكن ان يحدث لهن حمل يستلزم مقارنة فائدة الدواء بالخطر المحتل حدوثه للأم والطفل.

Sezen Feb 3, 2012, 9:28:07 PM

This means there is insufficient calcium ion influx into presynaptic terminal resulting in reduced exocytosis of acetylcholine containing vesicles. 1 Clinical uses 2 Chemistry 3 Pharmacokinetics 4 References 5 Further reading Edrophonium (by the so-called Tensilon test) is used to differentiate myasthenia gravis from cholinergic crisis and Lambert-Eaton. In a cholinergic crisis, where a person has too much neuromuscular stimulation, edrophonium will make the muscle weakness worse by inducing a depolarizing block.

user12624 Jul 5, 2018, 8:42:31 AM

More serious if you have a reaction like slow heart rate; feeling like you might pass out; jaundice (yellowing of your skin or eyes); confusion, spinning sensation, loss of balance; or seizure (convulsions). Robaxin is a muscle relaxant which used for relieving muscle pain and discomfort caused by sprains and strains. Immediately find medical help if you experience any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also, contraindications include coma or pre-coma states, brain damage or epilepsy, myasthenia gravis. Store at room temperature between 20-25 C (68-77 F).

Langolier Apr 2, 2014, 3:37:24 PM

Never give it to other people even if their condition appears to be the same as yours. Your dose will be printed on the label of the pack to remind you about what the doctor said to you. This is so your doctor can check on your progress.

Justin Hale Mar 12, 2019, 2:55:32 AM

• NAADS as abbreviation means "Nerve Agent Antidote Delivery System". This acronym/slang usually belongs to Government & Military category. • One of the definitions of NAADS is "Nerve Agent Antidote Delivery System".

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