A medicine may also have some unintended side effects in addition to the effects that are required. Even though not all of these side effects are likely to occur, if they do, medical attention may be required. Despite the low incidence, using estrogens may increase your risk of developing breast cancer. Men taking estrogen have been known to develop breast cancer. Fast heartbeat, fever, hives, hoarseness, increased breast size in both sexes, skin irritation or itchiness, joint pain, stiffness, or swelling, rash, swelling of the feet and lower legs, and breast pain in both sexes. Other symptoms include tightness in the chest, difficulty breathing or swallowing, rapid weight gain, and wheezing. Changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding) chest pain chills cough heavy non-menstrual vaginal bleeding lumps in, or discharge from, breast (in females and males) pains in the stomach, side, or abdomen yellow eyes or skin If you experience any of the following side effects, consult your doctor right away: Talk to your doctor about the following potential effects: Headache (sudden or severe) loss of coordination (sudden) loss of vision or change of vision (sudden) pains in the chest, groin, or leg, especially in the calf of leg shortness of breath (sudden and unexplained) slurring of speech (sudden) weakness or numbness in the arm or leg Endometrial cancer is not a risk if the uterus has been surgically removed (total hysterectomy). Incidence not known rare or less frequent more prevalent Rare Blood clots may result in the following side effects, which may cause a heart attack, stroke, or death. The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. If a progestin (another female hormone) is added to or replaces some of your estrogen dosage, the risk is also decreased. Rarely do these side effects occur, and when they do, it is in men receiving high estrogen doses for cancer treatment. This risk seems to increase as the dose and the length of use increase. There is less risk when using estrogens in low doses for a shorter period of time than a year. Taking estrogens to replace estrogen rarely has serious side effects in women. only for men receiving treatment for prostate or breast cancer
Find out more by speaking with your doctor or pharmacist. Tell your doctor in particular if you take: other medications used vaginally St. John's Wort (Hypericum perforatum), phenobarbital (Luminal), carbamazepine (Carbatrol, Epitol, Tegretol), rifampin (Rifadin, Rimactane, in Rifamate), erythromycin (E.E.S., Erythrocin), clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Spor Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Don't smoke. Grapefruit-related products ought to be avoided. Grapefruit and grapefruit juice may interact with conjugated estrogens and lead to unwanted side effects. While using conjugated estrogens, you run a significantly higher risk of developing blood clots, having a stroke, or having a heart attack.