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uptodate prednisone dosing

Prednisone, which is frequently prescribed and has about four times the potency of hydrocortisone as a glucocorticoid, is metabolized to prednisolone and has little mineralocorticoid activity. If long-term therapy required, the lowest possible effective dose should be used used to treat a variety of illnesses in both adults and children, such as asthma, COPD, SLE, rheumatoid and psoriatic arthritis, as well as to prevent transplant rejection and many allergic, inflammatory, and dermatological conditions

Other names for this medication:
Winpred, Deltasone, Rayos

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Tiova, Cycrin, Artane, Nasonex, Diamox, Lamotrigine, Mebendazole, Kemadrin, Topiramate, Galantamine, Levothyroxine, Ursodiol


Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.


If you experience any of these or any other strange symptoms while taking prednisone in decreasing doses or after stopping the medication, call your doctor right away. Despite feeling well, keep taking prednisone. Prednisone should not be stopped without first consulting your doctor. Never take it in quantities or for periods of time other than those recommended by your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Follow these directions carefully. If you are taking prednisone to treat a long-lasting disease, the medication may help control your condition but will not cure it. Use the medication's included, specially marked dropper to measure your dose if you're taking the concentrated solution. If you suddenly stop taking prednisone, your body may not have enough natural steroids to function normally. Prednisone is available in the following forms: tablets, delayed-release tablets, liquid solutions, and concentrated solutions for oral administration. Patients with acquired immunodeficiency syndrome (AIDS) may also receive prednisone in combination with antibiotics to treat a specific type of pneumonia. Prednisone is usually taken with food one to four times a day or once every other day. Do not chew, crush, or dissolve the delayed-release tablet; simply swallow it whole. Follow the prednisone instructions exactly. If you want to consume grapefruit or grapefruit juice while taking this medication, consult your doctor. The risks of using this medication for your condition should be discussed with your doctor. If your symptoms get better or worse, if you get sick, or if your health changes while you're receiving treatment, let your doctor know. Extreme fatigue, weakness, sluggishness, upset stomach, weight loss, changes in the color of the skin, sores in the mouth, and a craving for salt are just a few symptoms that may result from this. Ask your doctor or pharmacist for more details if you believe this medication should be used for something else. You may mix the concentrated solution with juice, other flavored liquids, or soft foods such as applesauce. Your doctor may also need to change your dose if you experience unusual stress on your body such as surgery, illness, infection, or a severe asthma attack. A calcium or potassium supplement may also be suggested by your doctor. To ensure that you are always taking the lowest dose of prednisone that works for you, your doctor may frequently adjust your prednisone dosage during your treatment. A low-salt, high-potassium, or high-calcium diet may be recommended by your doctor. Prednisone doses should be taken at specific times each day, as directed by your doctor. Depending on your condition and how you react to treatment, you will need to follow a specific dosing schedule.

Missed dose

Call your doctor or pharmacist if you miss a dose and do not know what to do. To make up for a missed dose, do not take a second dose. When you first start taking prednisone, discuss with your doctor what to do if you miss a dose. Write down these instructions so that you can refer to them later.


Call your doctor or the nearest Poison Control Center if you take too much prednisone, or go to the hospital right away for emergency care.


This medication should not, however, be flushed down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication tightly closed in the original container and out of the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

For more information, consult your physician or pharmacist. For medical guidance on side effects, call your doctor. Common side effects of prednisone include: dizziness hypertension slow healing retention of fluid resulting in swelling acne electrolyte imbalances decreased immune system function decreased bone density depression inappropriate happiness nausea joint and muscle pain blurred vision headache abnormal distribution of body fat This is not a complete list of prednisone side effects. See “Drug Precautions” section. Prednisone has been associated with serious side effects. Call 1-800-FDA-1088 to contact the FDA and report side effects.


Give a list of all your medicines to any healthcare provider who treats you. John's wort, an antibiotic like clarithromycin or telithromycin, an antifungal drug like itraconazole, ketoconazole, posaconazole, or voriconazole, birth control pills and other hormones, a blood thinner like warfarin or Coumadin, a diuretic or "water pill," the antivirals for hepatitis C boceprevir or telaprevir, HIV/AIDS medications like atazana Prednisone and a variety of medications can interact. Not all possible interactions are listed here. Prednisone drug interactions (more detail) Any medications you start using or stop using while taking prednisone should be disclosed to your doctor, particularly: This includes prescription and over-the-counter medicines, vitamins, and herbal products. This list is not complete and many other drugs can interact with prednisone. Digoxin, digitalis, cyclosporine, amphotericin B, and St.


Corticosteroid deficiency after drug withdrawal: Once you stop taking prednisone, your body’s ability to produce certain steroid hormones may be impaired. Reduced bone formation: Prednisone can stop the growth of bones, which may lead to osteoporosis and a decrease in bone density. Until you are aware of how prednisone affects you, avoid operating heavy machinery or driving. Prednisone should not be taken if you have a fungal infection or an allergy to it. Immunosuppression: Prednisone decreases your body’s immune response to infections. Additionally, because prednisone use reduces the immune response, it can make people more sensitive to vaccines. Ophthalmic (eye) problems: Prednisone can lead to cataracts and glaucoma. Prednisone can result in holes in the lining of the stomach or intestines, which can result in perforation of the digestive tract. Prednisone has the potential to make you queasy. If you have ever had tuberculosis, let your doctor know. Prednisone has been linked to some serious side effects, such as an allergic reaction and hypersensitivity reaction. Hives, trouble breathing or swallowing, swelling, rash, and itching are signs of an allergic reaction. Cardiac and renal issues can also result from prednisone use because it can raise blood pressure, cause fluid and sodium retention, and increase potassium and calcium excretion. If you have a history of heart or kidney disease, let your doctor know. If you have a history of stomach ulcers or other digestive system issues, let your doctor know.

Why is prednisone prescribed with Zytiga?

Zytiga is taken with prednisone to help manage side effects that might occur with this prostate cancer treatment. Zytiga blocks the production of cortisol from your adrenal glands. Prednisone helps to replace the lost cortisol that can cause side effects such as low blood potassium levels, fluid build up (edema), or high blood pressure.

What is prednisone prescribed for?

Prednisone is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids.

Why does prednisone make me feel good?

Prednisone affects areas of the brain that manage the regulation of different neurotransmitters, including serotonin and dopamine — the “feel-good” hormones. Feeling happy is a great side effect some people feel with prednisone. Other responses are more menacing, especially if you don't know what to expect.

What does prednisone do to your body?

Steroid drugs, such as prednisone, work by lowering the activity of the immune system. The immune system is your body's defense system. Steroids work by slowing your body's response to disease or injury. Prednisone can help lower certain immune-related symptoms, including inflammation and swelling.

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Rawi Mar 6, 2015, 2:41:24 AM

Weight Gain I’d gain about 80 pounds.. I’d get diabetes … I’d have blood pressure … I’d be miserable until I came off of the meds .. which also takes a lifetime to try and come off once you’re on. !” Long-Term That it would cause my hip to disintegrate and I would be left in a wheelchair Bones That it would make my bones so thin that I would end up with a fractured vertebrae. I didn’t understand that I may need it for the rest of my life.” Withdrawal “I wish someone would have warned me about the withdrawal. Thousands of people in a prednisone support group were asked “What do you wish you’d known before taking prednisone?” Hundreds answered, with many poignant comments about prednisone. The least surprising issue is insomnia or sleep disturbances.

Reef Loretto Dec 16, 2012, 7:39:37 PM

The most pronounced bone loss happens within those first three months. Moon Face doesn’t usually start at the beginning. I wish I could say, “You will experience insomnia at nine o’clock tonight.” But I can’t because prednisone side effects are so dependent on you! I can’t tell when prednisone side effects start.

Ioannis Koukoulis Oct 16, 2013, 10:22:14 AM

Prednisone is available as tablets of 1, 2.5, 10, 20, and 50 mg; extended release tablets of 1, 2, and 5mg; and oral solution of 5mg/5ml. If you notice other effects not listed above, contact your doctor or pharmacist. You may report side effects to Health Canada at 1-866-234-2345. Serious side effects include reactions to diabetes drugs, infections, and necrosis of the hips and joints. Talk with your doctor, pharmacist, or other medical professional if you have questions about prednisone.

Vladimir Kovalchuk Jul 11, 2014, 12:16:01 PM

Heck, even my nose was “pregnant” with swelling. The Water Will Go Away Like giving birth, once you finally stop taking prednisone, the water weight will go away. Like the girls on the baseball team counting the time it took the coach, played by Tom Hanks, to finish peeing, it was taking so long I thought I should time myself!

dreamzspl May 1, 2017, 11:31:51 AM

Prednisone is one of many IVF meds that are indicated for use in treating infertility. If you have any of these symptoms seek medical attention immediately. Of the infertility drugs on the market, Prednisone has a successful track record resulting in pregnancy, especially when combined with other medications. Prednisone is one of many high quality infertility medications offered by IVFPrescriptions.

CTimon Dec 16, 2013, 7:16:32 AM

We’ve compiled the following list of common concerns and side effects for anyone with a child taking prednisone. Prednisone is a widely used initial therapy for Nephrotic Syndrome. As with any treatment, risks and benefits must be weighed. Improper growth and development Behavior or attention problems Unhealthy weight gain Acne Weight gain Fluid retention Raised blood pressure Sleeplessness Increased hunger Stretch marks Cataracts Thinning of bones (osteoporosis) Risks of serious infections Ulcers Adrenal insufficiency FACT: It is important prednisone is not stopped abruptly without talking to your doctor.

PraveenMax Nov 18, 2010, 2:17:43 PM

Both of these drugs are available at most pharmacies. That said, methylprednisolone and prednisone are also both covered by most health insurance plans. You and your doctor will decide which form is best for you, so talk to them about any concerns you have about paying for your medication. They cost about the same, but prednisone is slightly less expensive than methylprednisolone.

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