Serotonin 5-HT3 receptor antagonist ondansetron is used postoperatively and during chemotherapy for cancer to stop nausea and vomiting.
Other names for this medication:
Zofran, Zuplenz
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In the adult patient population, oral ondansetron tablets and orally disintegrating tablets (ODT) are recommended for the following purposes: - the prevention of nausea and vomiting related to emetogenic cancer chemotherapy, including high dose (i.e. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy; and - the prevention and treatment of postoperative nausea and vomiting. Ondansetron's effectiveness and tolerance in treating post-chemotherapy and radiotherapy-induced nausea and vomiting were comparable to those seen in younger adults in the geriatric (>65 years of age) patient population. However, there is limited clinical experience with ondansetron's use in the prevention and treatment of postoperative nausea and vomiting, and it is not recommended for use in the geriatric patient population. Ondansetron tablets, ondansetron ODT, and ondansetron injection are not recommended for use in any age group of the pediatric (4-18 years of age) patient population. However, ondansetron tablets, ondansetron ODT, and ondansetron injection were effective and well tolerated when given to children 4-12 years of age for the treatment of post-chemotherapy induced nausea and vomiting. ii) Ondansetron injection formulations for intravenous administration are recommended for: - the treatment and prevention of postoperative nausea and vomiting; - the prevention of nausea and vomiting related to emetogenic cancer chemotherapy, including high dose (i.e. greater than or equal to 50 mg/m2) cisplatin therapy.
After the first dose has been taken for eight hours, a second dose of 10 ml should be given. One to two days after chemotherapy is finished, give one 4 mg film every three hours. Administer one 8 mg film twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy. The first dose should be given 30 minutes before chemotherapy, and the following doses should be given 4, and 8 hours later. Chemotherapy-Induced Nausea and Vomiting - Adults, Pediatric patients (6 months to 18 years): 8 mg tablet/orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose. 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose. For daily fractionated radiotherapy to the abdomen, 10 ml (8-mg) of ondansetron oral solution should be taken 1 to 2 hours prior to radiotherapy. Subsequent doses should be taken every 8 hours after the first dose. For a single high-dose fraction of radiotherapy to the abdomen, one 10 ml dose of ondansetron oral solution should be given one to two hours prior to radiotherapy, with subsequent doses given every eight hours after the first one for one to two days after radiotherapy is finished. For total body radiotherapy, 10 ml (8 mg) of ondansetron oral solution should be taken 1 to 2 hours prior to each daily fraction of radiotherapy. Three 0.15 mg/kg doses, each containing a maximum of 16 mg, were intravenously infused over the course of 15 minutes. Moderately emetogenic cancer chemotherapy: 10 ml (8 mg) of oral ondansetron solution given 30 minutes prior to the start of the emetogenic chemotherapy One 10 ml dose should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy. The recommended oral dosage for radiotherapy-induced nausea and vomiting in adults, the elderly, and children 12 years of age and older is 10 ml (8 mg) of ondansetron oral solution three times per day. Pediatric (4-11 years): 5 ml (4 mg) Ondansetron Oral Solution should be taken 30 minutes before the start of chemotherapy. Patients under the age of 11 who are pediatric patients should take one 4 mg film three times per day. Following radiotherapy, 8 mg should be taken orally every 8 hours for up to 5 days. 4 mg orodispersible tablet: Three doses of 0.15 mg/kg, with a maximum of 16 mg per dose. Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy: Adult oral dose: 24 mg given successively as three 8 mg films 30 minutes before the start of chemotherapy. Postoperative Nausea and Vomiting (Adults/Geriatric/Child of 12 years or over): 20 ml (16 mg) Ondansetron Oral Solution 1 hour before induction of anesthesia. Oral Soluble Film: Prevention of nausea and vomiting associated with postoperative nausea and vomiting (Ad Chemotherapy-induced Nausea and Vomiting- Adults/Geriatric/Child of 12 years or over: Highly emetogenic cancer chemotherapy: 30 ml (24 mg) Ondansetron Oral Solution administered 30 minutes before start of emetogenic chemotherapy. Postoperative Nausea and Vomiting- Adults: 8 mg tablet/orodispersible tablet: 16 mg given as two 8 mg tablets. 4 mg orodispersible tablet: 16 mg Injection: Postoperative nausea and vomiting: The adult dose is 16 mg given successively as two 8 mg films 1 hour before anesthesia. Adults and children 12 years of age and older should take one 8 mg film 30 minutes prior to chemotherapy, followed by an 8 mg dose eight hours later, to prevent nausea and vomiting brought on by chemotherapy for cancer that is moderately emetogenic. The adult dosage is one 8 mg film three times per day to prevent nausea and vomiting brought on by radiotherapy. Adults: 8 mg tablet/orodispersible tablet, initially taken 1 to 2 hours prior to radiotherapy to prevent nausea and vomiting brought on by the treatment. After the first dose, 4 and 8 hours should pass before taking the additional 2 doses. Following the end of chemotherapy, a 5 ml oral solution should be given three times per day (every 8 hours) for a couple of days.
Do not take a double dose to make up for a missed one. To continue with your regular dosing schedule, skip the missed dose if it is almost time for the next one. If you miss a dose, take it as soon as you remember.
If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Dial 1-800-222-1222 to reach the poison control hotline in the event of an overdose. Additionally, information is accessible online at https://www.poisonhelp.org/help. Symptoms of overdose may include: sudden loss of vision for a short time dizziness or lightheadedness fainting constipation irregular heart beat
How should any unneeded medications be disposed of? Ask your healthcare provider. information on the correct dosage of ondansetron Don't freeze. Do not keep outdated medicine or medicine no longer needed. Avoid freezing. Keep out of children's reach. Up until the time of use, keep the medication in the foil pouch. Until you're ready to use it, keep any unused soluble film in the foil pouch. Store away from heat sources and bright light at room temperature. Away from heat, moisture, and bright light, keep the medication at room temperature in a closed container.
When suddenly rising from a lying or sitting position, you may experience the following symptoms: agitation, blistering, peeling, or loosening of the skin, chills, diarrhea, dizziness, faintness, or lightheadedness; a fixed position of the eye; hoarseness; an inability to move the eyes; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; no pulse or A medication may have side effects in addition to the ones that are intended. Additionally, your healthcare provider might be able to provide you with information on how to avoid or lessen some of these side effects. While not all of these side effects are likely, if they do, they might require medical attention. Anxiety difficulty having a bowel movement (stool) dry mouth general feeling of discomfort or illness hyperventilation irritability shaking trouble sleeping Pain in the arm, back, or jaw Chest pain, discomfort, tightness, or heaviness Cough Reduced Urination Difficulty Breathing Difficulty Swallowing Dry Mouth Fast, pounding, or Irregular Heartbeat or Pulse Increased Thirst Loss of Appetite Loss of Bladder Control Loss of Consciousness Mood Changes Muscle Pain or Cramps Nausea or Vomiting Noisy For medical advice about side effects, contact your doctor. If any of the following side effects appear, consult your doctor right away: If any of the following side effects persist, are bothersome, or if you have any questions about them, consult your doctor: confusion fast heartbeat fever headache dizziness difficulty breathing Decrease in the frequency of urination decrease in the urine volume difficulty with passing urine (dribbling) painful urination Difficulty with speaking drooling loss of balance control muscle trembling, jerking, or stiffness shuffling walk stiffness of the limbs uncontrolled movements, especially of the face, neck, and back feeling of warmth hiccups skin redness on the arms, face, neck, and, sporadically, upper chest Consult a healthcare professional if you experience any additional effects. Unknown prevalence Less common Ondansetron injection Ondansetron oral, injection, intravenous (advanced reading) Ondansetron orally disintegrating tablets Ondansetron tablets Other brands Zofran, Zofran ODT, Zuplenz Professional resources Prescribing information More about ondansetron Side effects Drug interactions Dosage during pregnancy or breastfeeding Reviews (440) Patient tips Drug images Compare alternatives Pricing & coupons Drug class: 5HT3 receptor antagonists More typical Effects of Ondansetron (more information) Some patients might also experience other side effects not mentioned here. Rare Some adverse effects could happen, but they typically don't require medical attention. As your body gets used to the medication, these side effects may go away during treatment. Call 1-800-FDA-1088 to report side effects to the FDA.
Give a list of all your medicines to any healthcare provider who treats you. Using ondansetron concurrently with certain medications, such as antibiotics, antidepressants, heart rhythm medications, antipsychotic medications, and medications to treat cancer, malaria, HIV, or AIDS, increases your risk of experiencing a serious heart problem. Drug interactions with ondansetron (more information) Taking ondansetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor about all of your current medications, as well as any you start or stop taking while receiving ondansetron treatment. If you also use: This covers both prescription and non-prescription drugs, vitamins, and herbal products. Many other medications can interact with ondansetron; this list is not exhaustive. medication for nausea and vomiting prevention, narcotic (opioid) medication, medication for depression, medication for psychiatric disorders, or medication.
Hypersensitivity reactions have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. It should not be used instead of nasogastric suction. Ondansetron is not a drug that stimulates gastric or intestinal peristalsis. It is possible for a progressive ileus and/or gastric distension to go unnoticed in patients taking ondansetron after abdominal surgery or in patients experiencing nausea and vomiting brought on by chemotherapy.
What are the side effects of ondansetron HCL?
Headache, fever, lightheadedness, dizziness, drowsiness, tiredness, constipation, or redness/pain/burning at the injection site may occur. If these effects persist or worsen, notify your doctor promptly.
How long does it take for ondansetron take to kick in?
You can take ondansetron with or without food. Ondansetron should start to work within 30 minutes to an hour. Ondansetron tablets are available in two different forms – tablets or oral disintegrating tablets (also called ODT). Tablets: swallow the tablets with a glass of water.
Is ondansetron given IM or IV?
Ondansetron comes as a solution (liquid) to be injected intravenously (into a vein) or intramuscularly (into a muscle) by a health care provider in a hospital or clinic. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy.
What is ondansetron HCL used for?
Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.
Is ondansetron hcl a narcotic?
Is Zofran (ondansetron) a narcotic? No, Zofran (ondansetron) is not a narcotic, instead it belongs to a class of medication called 5-HT3 (serotonin) receptor antagonist.
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No alteration of daily dosage or frequency of dosing, or route of administration are required. For the prevention of PONV: Ondansetron can be administered orally or by intravenous or intramuscular injection. Patients with poor sparteine/debrisoquine metabolism The elimination half-life of ondansetron is not altered in subjects classified as poor metabolisers of sparteine and debrisoquine. The total dose over twenty-four hours (given as divided doses) must not exceed adult dose of 32 mg. No alteration of oral dose or frequency of administration is required.
When the vial is stored upright after first use, clumps may occasionally form on the top of the vial. Ask your doctor or pharmacist if you have questions.If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat. Check the vial and the vial top carefully for particles.
It should not be understood to indicate that the use of Ondansetron is safe, appropriate or effective for you. How to reduce the risk of Ondansetron drug interactions and side effects? Ondansetron can cause side effects such as tiredness, dizziness, weakness, diarrhea, constipation, headache, and fever. • Should certain beverages, foods and other products be avoided when I take Ondansetron?
anthracyclines (such as doxorubicin, daunorubicin or trastuzumab), antibiotics (such as erythromycin), antifungals (such as ketoconazole), antiarrhythmics (such as amiodarone) and beta blockers (such as atenolol or timolol) may increase the risk of arrhythmias. The safety of Ondansetron for use in human pregnancy has not been established. phenytoin, carbamazepine, and rifampicin), the oral clearance of ondansetron was increased and Ondansetron blood concentrations were decreased.
Also, seek emergency medical help if you have symptoms or signs of a serious allergic reaction called anaphylaxis to Zofran ODT: Rash such as hives Wheezing or trouble breathing Swelling of your face, lips, tongue, or throat Severe lightheadedness Fever Chills Lastly, if you have just had abdominal surgery or are taking chemotherapy, Zofran ODT may mask the signs and symptoms of a bowel obstruction. Do not take other medicines unless they have been discussed with your doctor. Zofran ODT is available as an orally disintegrating tablet.