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Clindamycin
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clindamycin prophylaxis dose

An effective treatment for severe infections brought on by anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria is clindamycin, a lincosamide antibiotic.

Other names for this medication:
Ziana, Xaciato, Cleocin, Clindacin, Biacna, Onexton, Clindesse, Clindoxyl, Dalacin C, Duac, Cleocin-T

Similar Products:
Mikacin, Ampicillin, Trimox, Acillin, Cefuroxime, Ciprodac, Azax, Aralen, Cephadex, Cenmox, Roxithromycin, Macrobid, Doxycycline, Biaxin, Levofloxacin, Novamox, Ethionamide, Vibramycin, Sumycin

Description

By attaching to the 23S RNA of the 50S subunit of the bacterial ribosome, clindamycin prevents bacteria from synthesizing proteins. It hinders both the ribosome's construction and the process of translation. Although the exact mechanism by which topical clindamycin treats acne vulgaris is not known, it may be connected to its activity against the bacteria Propionibacterium acnes, which has been linked to acne. The three-dimensional structure of clindamycin is similar to the 3'-ends of L-Pro-Met-tRNA and deacylated-tRNA during the peptide elongation cycle, which is thought to be the molecular mechanism by which this occurs. Clindamycin acts as a structural analog of these tRNA molecules, impairing peptide chain initiation and possibly inducing the dissociation of peptidyl-tRNA from bacterial ribosome

Dosage

Clindamycin comes as a capsule and a solution (liquid) to take by mouth. In some cases, clindamycin is used to treat individuals who are at risk of developing endocarditis following a dental procedure, which is an infection of the heart valves. Clindamycin is also occasionally used to treat acne, and it is combined with other drugs to treat malaria and anthrax, two serious illnesses that can be spread by mosquitoes in some regions of the world. Anthrax is a serious illness that can be intentionally spread as part of a terrorist attack. Additionally, bacterial vaginosis—an infection brought on by an overabundance of a particular type of bacteria in the vagina—can occasionally be treated with clindamycin. When other medications are ineffective for treating these conditions, clindamycin is also occasionally used to treat ear infections, tonsillitis (an infection that causes swelling of the tonsils), pharyngitis (an infection that causes swelling in the back of the throat), and toxoplasmosis (an infection that can cause serious problems in people with weakened immune systems or in unborn children whose mothers are infected). Never take it in quantities or frequencies other than those recommended by your doctor. If there is anything you do not understand about the instructions on your prescription label, ask your doctor or pharmacist to clarify it. Your infection might not be completely treated if you stop taking clindamycin too soon or skip doses, and the bacteria might develop an antibiotic resistance. Call your doctor if your symptoms do not disappear or worsen. Typically, three to four times a day are taken. Shake the liquid well before each use to mix the medication evenly. Clindamycin should be taken daily at approximately the same times. Take clindamycin as prescribed by your doctor. Despite feeling better, continue taking clindamycin until the medication is finished. So that the medication won't irritate your throat, take the capsules with a full glass of water. Talk to your doctor about the risks of using this medication for your condition. The length of your treatment depends on the type of infection you have and how well you respond to the medication. Inquire with your doctor or pharmacist for more details if you believe this medication may be prescribed for other purposes. Keep eating normally unless your doctor instructs you otherwise. During the first few days of clindamycin treatment, you should start to feel better.

Missed dose

To make up for missed doses, do not take more medication. If your next scheduled dose is approaching, skip the missed dose. When you remember, use the missed dose.

Overdose

Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room.

Storage

After two weeks, discard any unused clindamycin liquid. Clindamycin liquid should not be refrigerated because it might thicken and become difficult to pour. However, you should not flush this medication down the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication tightly closed in its original container away from the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature and away from excess heat and moisture (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. Always lock safety caps and immediately put the medication in a safe place, one that is up and away and out of their sight and reach. http://www.upandaway.org Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

A medication may also have some unintended side effects in addition to its desired effects. Even though not all of these side effects are likely to occur, if they do, medical attention may be required. Immediately consult your doctor or a nurse if any of the following side effects manifest themselves: Skin cracks, heat loss from the body, red, swollen skin, and scaly skin Incidence not known Rare

Interactions

When combined with amodiaquine or quinine for the treatment of multi-drug resistant Plasmodium falciporum infections. When used to treat infections brought on by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria like Streptococci, Staphylococci, and Pneumococci, clindamycin has been shown to be effective: upper respiratory infections, lower respiratory infections, skin and soft tissue infections, bone and joint infections, pelvic infections, intra-abdominal infections, septicemia and endocarditis, and dental infections.

Contraindications

Ask your pharmacist for a list of the ingredients. Make sure to list the following medications: erythromycin (E.E.S., E-Mycin, Erythrocin, others), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone, nelfinavir (Viracept), rifampin (Rifadin, in Rifamate, in Rifater, Rimactane), Before taking clindamycin, tell your doctor and pharmacist if you are allergic to clindamycin, lincomycin (Lincocin), any other medications, or any of the ingredients in clindamycin capsules or solution. Call your doctor if you become pregnant while taking clindamycin, and let them know if you're having surgery, including dental work, if you're taking clindamycin. If you will be taking clindamycin capsules, tell your doctor if you are allergic to aspirin or tartrazine (a yellow dye found in some medications). tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Many other medications may also interact with clindamycin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have or have ever had asthma, allergies, eczema (sensitive skin that often becomes itchy or irritated) or kidney or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. The dosage of your medications may need to be adjusted, and your health may need to be closely watched for any side effects.

Is Clindacin and clindamycin same?

Clindacin•P® contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. Each Clindacin•P® pledget applicator contains approximately 1 mL of topical solution.

Can I take clindamycin if I am allergic to penicillin?

Yes, you can. It is recommended that the use of the antibiotic clindamycin be reserved for patients who are allergic to penicillin or for those patients a healthcare provider determines penicillin to be an inappropriate treatment.

What strength does clindamycin gel come in?

CLEOCIN T Topical Solution and CLEOCIN T Topical Lotion contain clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. CLEOCIN T Topical Gel contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram.

Does clindamycin remove dark spots?

CLINDAMYCIN+TRETINOIN lightens post-acne dark spots by switching the damaged skin cells with newer ones. Thus, it lightens the tone of the skin and makes it brighter and stronger than before.

Can we use clindamycin gel daily?

Topical clindamycin will not cure your acne. However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases.

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Testimonials
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cati Oct 16, 2012, 9:03:05 PM

Avoid exposing the treated areas of skin to excessive sunlight, or to sunbeds or sunlamps. It should be used with caution during pregnancy, and only if the benefits to the mother outweigh any potential risks to the developing baby. Rita Ghelani (BPharm, MRPharmS) Pharmacist A UK registered practising pharmacist with over 20 years' experience, Rita is a member of the medical journalists’ association (MJA) and has a wealth of experience in community pharmacy. Duac gel should not be used for longer than 12 weeks at a time.

Maggie Harvey Jan 3, 2021, 7:05:46 PM

Clindamycin is systemically administered as capsules or injections for most infections, but topical formulations and vaginal preparations can be used for intravaginal or local applications on the skin. Oxygen is toxic to anaerobic bacteria, while aerobic bacteria can grow in the presence of oxygen because they produce enzymes that detoxify oxygen. Gram-negative bacteria have an additional membrane outside the cell wall that gram-positive bacteria lack.

Zoran Kostic Feb 21, 2017, 2:58:26 PM

Many drugs are commonly prescribed for off label use in veterinary medicine. Are there any drug interactions I should be aware of? What if I miss giving my pet the medication or my shipment is late? Its use to treat certain infections, such as toxoplasmosis, is ‘off label’ or ‘extra-label’.

Krishna Sep 27, 2013, 6:42:48 PM

It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin vaginal suppositories in November, 2004. Clindamycin vaginal cream is indicated for the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis) in non-pregnant women. Clindamycin in general is an antibiotic used for treating several other infections as well.

Amie Chen Jun 22, 2016, 6:49:46 AM

If you have been told to use clindamycin injection at home, it is very important that you use the medication exactly as directed. It is usually given two to four times a day. The length of your treatment depends on the type of infection you have and how well you respond to the medication. Use clindamycin injection until you finish the prescription, even if you feel better.

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