The use of oral contraceptives that contain only progestin has been linked to an increased risk of the following side effects: delayed follicular atresia/ovarian cysts, irregular menstruation, changes in menstrual flow, breakthrough bleeding/spotting, amenorrhea, and prolonged bleeding. In the Norgestrel Tablet clinical studies, 5% of subjects experienced the following side effects: Headache, dizziness, nausea, increased appetite, abdominal pain, cramps, and bloating, fatigue, vaginal discharge, dysmenorrhea, nervousness, backache, breast discomfort, acne.
Females with the potential to become pregnant are advised to use norgestrel tablets to avoid getting pregnant. These pills are not intended to be used as emergency contraception.
Drug Interactions: The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as phenytoin, carbamazepine, barbiturates, rifampin, efavirenz, bosentan and herbal preparations containing St. During concomitant use of Norgestrel and substances that may affect its efficacy, it is recommended that a nonhormonal back-up method of contraception (such as condom) be used in addition to the regular intake of Norgestrel Tablets. Effectiveness of progestin-containing hormonal contraceptives and emergency contraceptive ulipristal acetate may be decreased if progestin-containing hormonal contraceptives are used within five days after ulipristal acetate dosing. Another method of contraception ought to be taken into account for women who are undergoing long-term treatment with hepatic enzyme inducers. Absorption of hormones may be hampered by diarrhea and/or vomiting within four hours of taking a pill. The level of free thyroxine should, however, not change. If a woman wants to use norgestrel tablets after taking ulipristal acetate, she should wait no more than five days and use a safe barrier method for all subsequent sex until her next period. The following endocrine tests may be impacted by Norgestrel Tablet use: Sex hormone-binding globulin (SHBG) concentrations may be decreased. Hypericum perforatum, also known as John's Wort. Migraine/Headache: Because women who suffer from migraine may be at higher risk of stroke, it is important to evaluate the cause of the onset or exacerbation of migraine as well as the development of headache with a new pattern that is recurrent, persistent, or severe. This could result in unintended pregnancy or breakthrough bleeding. Because thyroid binding globulin (TBG) levels may drop, total thyroxine levels may also drop. For 28 days following the cessation of substances that have caused the induction of hepatic microsomal enzymes, use of a nonhormonal back-up method is advised. During the following 48 hours, women should use a nonhormonal backup method of birth control (like a condom or spermicide).