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nevirapine oral suspension

A non-nucleoside reverse transcriptase inhibitor called nevirapine is used as a component of an HIV-1 infection management regimen.

Other names for this medication:
Viramune

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Description

Nevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. Template or nucleoside triphosphates are not in competition with nevirapine's activity.

Dosage

Adult Patients: Nevirapine should be administered orally in combination with other antiretroviral medications once every day for the first 14 days, followed by twice daily doses of one 200 mg tablet. It is important to adhere to the manufacturer's dosage and monitoring recommendations for concomitantly administered antiretroviral therapy. Pediatric Patients: The recommended oral dose for pediatric patients 15 days and older is 150 mg/m² once daily for 14 days followed by 150 mg/m² twice daily thereafter. The incidence of rash has been seen to decline during the lead-in period. For any patient, the total daily dose shouldn't go over 400 mg.

Missed dose

Never take two doses at once to make up for missed ones. Skip the missed dose and carry on with your regular dosing schedule, though, if it is almost time for the subsequent dose. As soon as you realize you missed a dose, take it.

Overdose

Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room.

Storage

Store at 15 to 30 °C

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Side effects

You or your doctor can submit a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you experience a serious side effect. Call your doctor right away if you notice any of the signs and symptoms detailed in the section titled "IMPORTANT WARNING." Negative effects of nevirapine are possible. If any of these symptoms—headache, diarrhea, or stomach pain—are persistent or are severe, contact your doctor right away.

Interactions

Give a list of all your medicines to any healthcare provider who treats you. The effectiveness of nevirapine can be decreased or affected by a variety of medications. More about nevirapine Side effects Drug interactions Dosage information During pregnancy or Breastfeeding Reviews (6) Drug images Pricing & coupons En español Drug class: NNRTIs Patient resources Advanced Reading Nevirapine Extended-Release Tablets Nevirapine Tablets Nevirapine Oral Suspension Other brands Viramune, Viramune XR Professional resources Prescribing Information Related treatment guides HIV Infection Reduction of Perinatal Transmission of HIV Nevirapine drug interactions (more detail) Not all possible interactions are listed here. Tell your doctor about all of your current medications as well as any you begin or stop taking, in particular: This includes prescription and over-the-counter medicines, vitamins, and herbal products. This list is not complete and many other drugs can interact with nevirapine. A blood thinner (such as warfarin and others), an antibiotic or antifungal medication, a birth control pill or hormone replacement therapy, an ergot medicine (such as dihydroergotamine, ergonovine, and others), a heart or blood pressure medication, a medication to prevent organ transplant rejection, or a seizure medication.

Contraindications

Inform your doctor and pharmacist what prescription and over-the-counter drugs, vitamins, and dietary supplements you are taking, as well as any allergies you may have before beginning nevirapine treatment.

What is nevirapine used for?

Nevirapine is used in combination with other medicines for the treatment of the infection caused by human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Is nevirapine an NRTI?

Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is no longer widely used in the United States, mainly because safer and more effective antiretroviral medications are available. Nevirapine can cause severe rash and hepatitis, including immune-mediated, life-threatening hypersensitivity reactions.

What is nevirapine used for?

It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Nevirapine belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

When should I take nevirapine?

In many developing countries, a two-dose regimen of nevirapine (NVP) around the time of birth is advocated as the most cost-effective way to prevent mother to child HIV transmission. One dose is taken by the mother at the onset of labour and one dose is given to her baby, between 48 and 72 hours after birth.

What are the side effects of nevirapine?

The commonest side effects experienced by people taking nevirapine are rash, nausea, fatigue, fever, headache, vomiting, diarrhoea and abdominal pain. People taking nevirapine may also develop a low level of granulocytes, a type of white blood cell.

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Testimonials
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bessarabov Nov 15, 2010, 7:27:26 AM

Some authors have claimed that evidence of poor efficacy may have contributed to termination of the drug's development; the ASCENT study, one of the discontinued trials, showed aplaviroc to be under-effective in many patients even at high concentrations. Aplaviroc (INN, codenamed AK602 and GSK-873140) is a CCR5 entry inhibitor that belongs to a class of 2,5-diketopiperazines developed for the treatment of HIV infection. In October 2005, all studies of aplaviroc were discontinued due to liver toxicity concerns.

pkrog Jul 1, 2021, 10:08:50 AM

Nevirapine should be combined with at least two additional antiretroviral agents. Patients should be advised of the need to take Nevirapine every day as prescribed. The recommended dose of nevirapine for patients initiating nevirapine therapy is one 200 mg immediate-release tablet daily for the first 14 days (this lead-in period should be used because it has been found to lessen the frequency of rash), followed by one 400 mg prolonged-release tablet once daily, in combination with at least two additional antiretroviral agents. Patients currently on a nevirapine immediate-release twice daily regimen: Patients already on a regimen of nevirapine immediate-release twice daily in combination with other antiretroviral agents can be switched to Nevirapine 400 mg prolonged-release tablets once daily in combination with other antiretroviral agents without a lead-in period of nevirapine immediate-release.

JohnOsborne Mar 17, 2021, 12:11:39 AM

In contrast the mutated side-chains can be seen in the NNRTI pocket for all seven structures reported here, eliminating the possibility that disordering contributes to the mechanism of resistance. (2000) J Biol Chem 275: 5633 Crystallographic Analysis of the Binding Modes of Non-Nucleoside Thiazoloisoindolinone Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies • Ren, J.,&nbspEsnouf, R.M.,&nbspHopkins, A.L.,&nbspStuart, D.I.,&nbspStammers, D.K. The main contribution to drug resistance for Tyr181Cys and Tyr188Cys RT mutations is the loss of aromatic ring stacking interactions for first generation compounds, providing a simple explanation for the resilience of second generation NNRTIs, as such interactions make much less significant contribution to their binding. Mutations at either Tyr181 or Tyr188 within HIV-1 reverse transcriptase (RT) give high level resistance to many first generation non-nucleoside inhibitors (NNRTIs) such as the anti-AIDS drug nevirapine.

Snrky Mar 10, 2014, 6:06:33 AM

By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Achillion Pharmaceuticals, Inc. for the treatment of HIV infection. Studies have also suggested that elvucitabine may be effective against hepatitis B virus (HBV). (In vitro studies are studies done in test tubes or other laboratory equipment and not on animals or humans). However, in vitro studies have suggested that elvucitabine may work on certain HIV strains against which other NRTIs, such as lamivudine and emtricitabine, no longer work.

antogerva Jan 7, 2022, 4:35:16 PM

Consider therapy modification Methadone: Reverse Transcriptase Inhibitors (Non-Nucleoside) may increase the metabolism of Methadone. Avoid combination Sarilumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy Siltuximab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). This mechanism applies to coadministration of efavirenz, etravirine, and nevirapine. Voriconazole may increase the serum concentration of Reverse Transcriptase Inhibitors (Non-Nucleoside).

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