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bupropion dosing for

Seasonal affective disorder (SAD; episodes of depression that happen at the same time every year [typically in the fall and winter but sporadically may occur in the spring or summer]) is another condition that is treated with bupropion (Aplenzin, Wellbutrin XL). Bupropion (Aplenzin, Wellbutrin, Wellbutrin SR, Wellbutrin XL) is used to treat depression. To help people stop smoking, bupropion (Zyban) is used. The drug bupropion belongs to the group of drugs known as antidepressants. It functions by boosting particular types of brain activity.

Other names for this medication:
Forfivo, Wellbutrin, Budeprion, Zyban, Aplenzin, Contrave

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When used in conjunction with mood stabilizers, bupropion is also used off-label as a first-line treatment for people who have bipolar disorder and ADHD concurrently. Major depressive disorder (MDD), seasonal affective disorder (SAD), and smoking cessation are all conditions that can be treated with bupropion. When used in combination with as the marketed product ContraveⓇ, bupropion is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of: 30 kg/m^2 or greater (obese) or 27 kg/m^2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).


Both tablets and long-acting (sustained-release) tablets of bupropion are available for oral consumption. Bupropion is also occasionally used to treat attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people their age) and episodes of depression in people with bipolar disorder (manic depressive disorder; a condition that causes episodes of depression, episodes of mania, and other abnormal moods). Bupropion should still be taken even if you feel fine. Without first consulting your physician, do not stop taking bupropion. Never take it in quantities or frequencies other than those recommended by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Bupropion shouldn't be taken too soon before bed if you have trouble falling or staying asleep. Before you experience the full benefits of bupropion, it could take up to 4 weeks. Occasionally, the medication is stopped after two weeks of taking a lower dose of bupropion. Avoid splitting, chewing, or crushing the extended-release and sustained-release tablets. Instead, swallow them whole. Take bupropion every day at roughly the same time(s). Take bupropion exactly as directed. If the medication upsets your stomach, take bupropion with food. Talk to your doctor about the possible risks of using this medication for your condition. Each dose of the extended-release tablet (Aplenzin, Wellbutrin XL) should be spaced at least 24 hours apart. The extended-release tablet is typically taken once daily in the morning. Wellbutrin regular tablets are typically taken three times daily, at least six hours apart between each dose, or four times daily, at least four hours apart between each dose. The sustained-release tablet (Wellbutrin SR, Zyban) is typically taken twice daily, at least eight hours apart from one another. Ask your doctor or pharmacist for more details if you believe this medication may be prescribed for another purpose. Continue eating normally unless your doctor instructs you otherwise. It is typical for bupropion to be taken once daily in the morning beginning in the early fall, continuing through the winter, and ceasing in the early spring when it is used to treat seasonal affective disorder. Your dosage may be gradually decreased by your doctor. Initially prescribed at a low dose, bupropion is likely to be gradually increased by your doctor.

Missed dose

Always wait the full prescribed amount of time between bupropion doses. Never take two doses at once to make up for missed ones. Ignore the missed dose and carry on with my normal dosing schedule.


Bupropion overdose can be fatal. Muscle stiffness, hallucinations, an erratic or rapid heartbeat, shallow breathing, or fainting are some of the symptoms of an overdose. Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room.


You shouldn't flush this medication down the toilet, though. Instead, using a medication take-back program is the best way to get rid of your medication. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Store this medication out of children's reach in the tightly closed, original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more information. Store it at room temperature, away from heat sources, light, and moisture (but not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

Side effects from bupropion are possible. Tell your doctor if any of these symptoms are severe or do not go away: drowsiness anxiety excitement difficulty falling asleep or staying asleep dry mouth dizziness headache nausea vomiting stomach pain uncontrollable shaking of a part of the body loss of appetite weight loss constipation excessive sweating ringing in the ears changes in your sense of taste frequent urination sore throat seizures confusion hallucinating (seeing things or hearing voices that do not exist) irrational fears muscle or joint pain rapid, pounding, or irregular heartbeat fever rash or blisters itching hives swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs hoarseness difficulty breathing or swallowing chest pain Some side effects can be serious.


Avoid alcohol. Alcohol co-administration has the potential to worsen neuropsychiatric side effects and intensify CNS depressant effects. Pharmacokinetics are not significantly impacted by co-administration with food. Take with or without food.


Inform your doctor if you are taking an MAO inhibitor, such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate), or if you have recently stopped taking an MAO inhibitor within the previous 14 days. If you have an allergy to any of the ingredients in bupropion tablets, other medications, or bupropion, make sure to let your doctor and pharmacist know before starting to take bupropion. Tell your doctor and pharmacist what other prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Do not take more than one product containing bupropion at a time, as your doctor likely advised you not to.

Is bupropion SR or XL better for weight loss?

by Wellbutrin XL and Wellbutrin SR are different formulations of the antidepressant bupropion. Both Wellbutrin XL and Wellbutrin SR may cause weight gain or weight loss, but weight loss is more common. Not everyone taking these drugs will experience a change in weight.

What does bupropion do for a person?

Bupropion is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation). Symptoms of depression include: Depressed mood - feeling sad, empty, or tearful.

How much does a bupropion pill cost?

It belongs to a group of medications called NDRIs. The lowest GoodRx price for the most common version of bupropion is around $6.00, 70% off the average retail price of $20.24.

Is bupropion used for weight loss?

Wellbutrin (bupropion) is a prescription medication for depression and smoking cessation. Bupropion can cause weight loss in some people, so it's sometimes prescribed as a weight loss medication in the form of Contrave (a combination drug of bupropion and naltrexone).

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Xavier J Mar 13, 2017, 9:48:55 PM

In clinical practice with other bupropion-containing products, hypertension, in some cases severe and requiring acute treatment, has been reported. In patients of all ages who are started on CONTRAVE, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. • Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of suicidality, anxiety, agitation, irritability, unusual changes in behavior, and other symptoms, and to report such symptoms immediately to healthcare providers. Observe patients for the occurrence of neuropsychiatric adverse events. CONTRAVE is not approved for use in pediatric patients.

axel blaze Oct 4, 2020, 12:59:43 AM

Furthermore, those taking a dose of naltrexone equivalent to the full dose in Contrave were more successful than those taking a half dose. (3) In clinical studies, taking Contrave was found to increase the chance of participants losing weight. This combination is thought to reduce feelings of hunger and control cravings, supporting you to lose weight and keep it off. As part of a series of articles on weight loss options, will look in more detail at the ingredients, safety, and success rates of Contrave to help you decide if this medication might be right for you.

Anthony Ch Aug 26, 2018, 3:59:27 AM

Prior to initiating CONTRAVE, screen patients for history of bipolar disorder and the presence of risk factors for bipolar disorder (eg, family history of bipolar disorder, suicide, or depression). CONTRAVE is not approved for use in pediatric patients. Neuropsychiatric Adverse Events and Suicide Risk in Smoking Cessation Treatment CONTRAVE is not approved for smoking cessation.

Jakob Drachmann Havtorn Nov 21, 2018, 11:24:17 AM

The syndrome is commonly accompanied by psychiatric comorbidities and is associated with educational and occupational underachievement. Thus, alternative non-stimulant treatment approaches for ADHD have been explored. Objectives To assess the effects and safety of bupropion for the treatment of adults with ADHD. One of these alternatives is bupropion, an aminoketone antidepressant and non-competitive antagonism of nicotinic acetylcholine receptors.

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