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mirtazapine metabolic syndrome

Suicidality risk was elevated in pediatric and young adult patients during the first stages of treatment. Tetracyclic serotonergic and noradrenergic antidepressant unrelated to other classes of antidepressants utilized to treat adults with major depressive disorder

Other names for this medication:

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Mirtazapine's safety and efficacy in treating MDD in children are unknown. In the central nervous system, it is believed to have a positive impact on nerve cell communication and/or help the brain's chemicals balance out. Antidepressant mirtazapine is used. Adults with major depressive disorder may benefit from mirtazapine treatment. It is still not entirely clear how this medication functions.


Regardless of how you feel, keep taking mirtazapine. Disintegrating tablets of mirtazapine must not be broken. Without consulting your doctor, do not stop taking mirtazapine. Do not take more or less of it or take it more often than prescribed by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Both food and no food may be consumed with it. You might need a few weeks or longer to experience all of mirtazapine's advantages. It is typically taken at nighttime, once per day. Both tablets and orally disintegrating tablets of mirtazapine are available. To swallow disintegrating tablets, no water is required. It is impossible to store a tablet once it has been taken out of its blister pack. Follow the medication's directions precisely. The tablet will break down on the tongue and be able to be ingested with saliva. You should speak with your doctor or pharmacist for more details if you want to use this medication for a different purpose. Open the blister pack of a mirtazapine disintegrating tablet with dry hands, then place the tablet on your tongue to consume it. Unless your doctor tells you otherwise, continue your normal diet. Your dose will probably be reduced gradually by your doctor.

Missed dose

Do not combine two doses at once. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.


Call emergency services at 911 right away if the victim has fallen, experienced a seizure, is having trouble breathing, or cannot be roused. Call 1-800-222-1222 to reach the poison control hotline in the event of an overdose. Additionally, information is accessible online at


This medication should not, however, be flushed down the toilet. Instead, using a medication take-back program is the best way to get rid of your medication. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for toddlers to open. Keep this medication tightly closed in the original container and out of the reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more information. Store it at room temperature and away from excess heat and moisture (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and immediately store medications up and away and out of young children's sight and reach. Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot ingest them.

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Side effects

The most frequent side effects of mirtazapine include weight gain, increased appetite, dry mouth, dizziness, and drowsiness.


Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. John's wort, tramadol, tryptophan (also known as L-tryptophan), an antibiotic (clarithromycin, rifampin, rifampicin, telithromycin), an antifungal medication (itraconazole, ketoconazole), an antiviral medication to treat HIV/AIDS (indinavir, nelfinavir, ritonavir, saquinavir), a medication to Mirtazapine can be impacted by many medications, particularly: Drug interactions with mirtazapine (more information) More information on mirtazapine Adverse reactions Drug interactions Dosage guidance During pregnancy or breast-feeding Reviews (1,790) Patient advice Drug images Alternatives pricing & coupons In Spanish Drug class: tetracyclic antidepressants Patient resources Advanced Reading Mirtazapine Orally Disintegrating Tablets Mirtazapine Tablets Other brands Remeron, Remeron SolTab Professional resources Prescribing Information Related treatment guides Insomnia Anxiety Hot Flashes De This list does not include all possible drug interactions. Inform your doctor of all the medications you are taking. This covers vitamins, herbal products, prescription and over-the-counter medications, and other drugs as well. There may be other drugs that interact with mirtazapine; this list is not exhaustive. Using mirtazapine with other drugs that make you drowsy can worsen this effect. cimetidine; diazepam; St.


If you are uncertain whether you take an MAOI, including the antibiotic linezolid, consult your doctor, pharmacist, or other healthcare professional. Immediately contact your healthcare provider if you experience any of the following symptoms, or dial 911 in case of an emergency, especially if they are new, worse, or worry you: attempts at suicide acting on dangerous impulses acting aggressive or violent thoughts about suicide or dying experiencing new or worse depression experiencing new or worse anxiety or panic attacks having difficulty falling asleep engaging in more activity or talking than usual Children and adolescents should have height and weight monitored during treatment. 11. decreased neutrophils, a type of white blood cell essential for fighting infections. The most significant contributors to suicidal thoughts or behaviors are depression or other severe mental illnesses. Elderly people may be at greater risk for this. If you experience any of these symptoms, seek immediate medical attention: a high fever, uncontrolled muscle spasms, stiff muscles, rapid changes in heart rate or blood pressure, confusion, or passing out. Blood triglyceride and cholesterol levels that are higher Do not stop taking mirtazapine without first consulting your doctor. either an increase in appetite or weight. It is best to take mirtazapine just before bed. Within 14 days of beginning or stopping treatment with an MAOI, it is advised against using mirtazapine in combination with that drug. Keep all of your follow-up appointments with your doctor, and call in between appointments if you have any concerns about your symptoms. Low blood sodium (salt) levels. An enormous increase in energy, severe sleep problems, racing thoughts, reckless behavior, excessive happiness, or irritability are all signs of manic episodes. 3. Serious adverse effects from mirtazapine and other antidepressants include: 1. Mirtazapine may be associated with these serious side effects: trouble breathing, swelling of the face, tongue, eyes or mouth 2. When starting mirtazapine or altering the dose, pay close attention to any changes of this nature. Mirtazapine side effects can be severe or even fatal for those who take it soon after an MAOI. seizures 6. Neuroleptic Malignant Syndrome-like symptoms or Serotonin Syndrome. Rash, itchy welts (hives), or blisters that are severe allergic reactions that may also include fever or joint pain 10. Call your doctor right away if you experience any of the following symptoms, which include painful skin reddening, blisters/ulcers on the body or in the mouth, a severe rash with skin swelling, including on the palms of your hands and soles of your feet. Sleepiness. Stopping mirtazapine too quickly may cause potentially serious symptoms including: dizziness abnormal dreams agitation anxiety fatigue confusion headache shaking tingling sensation nausea, vomiting sweating Do not take mirtazapine if you: are allergic to mirtazapine or any of the ingredients in it. take a Monoamine Oxidase Inhibitor (MAOI). Suicidal thoughts or behaviors: During the first few months of treatment or when the dose is changed, antidepressant medications may cause some children, teenagers, or young adults to experience an increase in suicidal thoughts or behaviors. The following symptoms may also occur: headache, weakness, or unsteadiness; confusion; difficulties focusing, thinking, or remembering; and problems with memory. If you experience any infection-related symptoms, particularly flu-like ones like a fever, chills, sore throat, or mouth or nose sores, call your doctor right away. 4. A racing heartbeat, high or low blood pressure, sweating or fever, nausea, vomiting, or diarrhea are all symptoms of this potentially fatal condition. Other symptoms include muscle rigidity. Watch for these changes and call your healthcare provider right away if you notice: New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.

Who invented mirtazapine?

Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.

Is mirtazapine 15 mg a sleeping pill?

Mirtazapine has been shown to affect different phases of sleep. It reduces the duration of early, light stages of sleep and increases deep sleep 2 and also slightly reduces REM sleep (dream sleep). While it may seem like off-label use of mirtazapine could help with insomnia, it's not without its side-effects.

What drug class is mirtazapine?

Mirtazapine is in a class of medications called antidepressants.

What type of SSRI is mirtazapine?

Mirtazapine belongs to a group of medicines called tetracyclic antidepressants. These medications help balance the chemical messengers, or neurotransmitters, in the brain that regulate mood.

Is mianserin the same as mirtazapine?

It is a tetracyclic antidepressant (TeCA). Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs.

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Lanee Morin Aug 7, 2017, 2:57:35 PM

Mirtazapine may also be given in two divided doses (once in the morning and once at night-time, the higher dose should be taken at night). The clearance of mirtazapine may be decreased in patients with moderate to severe renal impairment (creatinine clearance <40 ml/min). The clearance of mirtazapine may be decreased in patients with hepatic impairment. The effective daily dose is usually between 15 and 45 mg; the starting dose is 15 or 30 mg. Mirtazapine begins to exert its effect in general after 1-2 weeks of treatment.

neutrin0 Feb 7, 2015, 7:58:09 AM

Therefore, an interval of 14 days is recommended between stopping MAO inhibitor therapy and starting mirtazapine, and vice versa. Such drugs to avoid include tryptophan, sumatriptan (Imitrex), linezolid (Zyvox), fluoxetine (Prozac), venlafaxine (Effexor), lithium (Eskalith, Lithobid), tramadol (Ultram), and St. John's wort. Mirtazapine should not be used with monoamine oxidase (MAO) inhibiting drugs such as phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl), or tranylcypromine (Parnate). High fever, convulsions, and even death can occur from such combinations. Carbamazepine (Tegretol) and phenytoin (Dilantin) decrease the blood concentration of mirtazapine by increasing the breakdown of mirtazapine in the liver, possibly reducing the effect of mirtazapine.

Nowmy Ibrahim Apr 28, 2011, 3:45:58 AM

Addiction can be overcome with education, treatment, and support from specialists who care. Addiction transference refers to swapping or replacing one addiction with another. Often, Remeron abuse and addiction are associated with comorbid addictions and co-occurring disorders. Dwelling on how to get more of the drug, the desired effects, and when to take the drug. Remeron should be tapered in the amount dosed over time instead of stopping cold turkey.

budi anduk Jun 14, 2015, 12:18:00 PM

Mirtazapine should not be used in children and adolescents under the age of 18 years as efficacy was not demonstrated in two short-term clinical trials (see section 5.1) and because of safety concerns (see sections 4.4, 4.8 and 5.1) Mirtazapine has an elimination half-life of 20-40 hours and therefore Mirtazapine is suitable for once daily administration. With an insufficient response, the dose can be increased up to the maximum dose. The clearance of mirtazapine may be decreased in patients with hepatic impairment.

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