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methotrexate injection sites

Antimetabolite of folic acid Use is contraindicated in patients with a nonmalignant diagnosis who are pregnant; due to the potential for serious or fatal adverse reactions, treatment with methotrexate requires an experienced physician Used for both malignant and nonmalignant conditions, including rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis, breast cancer, non-Hodgkin lymphoma, and ALL. Intrathecal methotrexate is also used to prevent and treat meningeal leukemia.

Other names for this medication:
Metoject, Rasuvo, Reditrex, Xatmep, Trexall, Nordimet, Otrexup

Similar Products:
Leukeran, Cyclophosphamide, Letrozole, Xeloda, Hydroxyurea, Cytoxan, Ondansetron, Nolvadex, Zofran, Capecitabine, Femara, Chlorambucil, Hydrea


Due to these side effects, methotrexate is frequently used to treat arthritic inflammation or to regulate cell division in neoplastic diseases like breast cancer and non-Hodgkin's lymphoma.,,,, Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. A folate derivative called methotrexate blocks several nucleotide-synthesising enzymes. The FDA approved methotrexate on December 7, 1953. Due to this inhibition, cell division is stopped as well as inflammation.


In a hospital or cancer treatment facility, methotrexate will be administered by a nurse or other qualified healthcare provider. The medical issue for which you are using the medication will also determine how many doses you take each day, how long you wait between doses, and how long you take it for. If you have any inquiries, speak to your doctor. Children—Your doctor must determine the dosage for you based on your child's body weight. Children—Your doctor must determine the use and dosage. Observe your doctor's orders or the instructions on the product's label. Adults—At first, 10 to 25 milligrams (mg) once per week for psoriasis in the form of an injection. Adults—7.5 mg once a week at first for rheumatoid arthritis or pediatric arthritis. The dose is typically no higher than 30 mg administered once weekly. Use caution if the medication in the syringe has changed color or has visible particles. If you inject Otrexup, Rasuvo, or Reditrex at home: If your dose is different, don't adjust it unless your doctor instructs you to do so. Make sure to rotate the body parts by keeping track of where you administer each shot. Shots of methotrexate can be administered subcutaneously, intravenously, intramuscularly, or into the spine (back or neck). Carefully read and adhere to the instructions. Depending on the medication's potency, you should take a different amount. For various patients, a different dose of methotrexate will be prescribed. The following information includes only the average doses of methotrexate. A patient information leaflet is included with the medication. Typically on the stomach or thigh, the medication is injected under your skin. The starting dose is 10 milligrams (mg) per square meter (m(2)) of body size once per week. This will lessen the chance of skin complications from the injection. Use a different body area each time you give yourself a shot. Your doctor may adjust your dose as needed.

Missed dose

If you forget to take your methotrexate dose, call your doctor for directions.


Methotrexate taken in excess can be fatal. Overdose symptoms can include unusual bleeding, mouth sores, vomiting, little to no urination, bloody or tarry stools, or coughing up blood or vomit that resembles coffee grounds. Call the Poison Help hotline at 1-800-222-1222 or seek immediate medical attention.


Store at room temperature (15-25°C).

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Side effects

If you experience any unusual issues while taking this medication, contact your doctor right away. You or your doctor can submit a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you experience a serious side effect. Call your doctor right away if you experience any of the following symptoms or any of those mentioned in the IMPORTANT WARNING section: dizziness, drowsiness, headache, swollen, tender gums, decreased appetite, reddened eyes, hair loss, seizures, confusion, weakness, or difficulty moving one or both sides of the body, loss of consciousness. Methotrexate may also have other side effects. There may be side effects from methotrexate. If any of these side effects persist or are severe, consult your doctor right away: dizziness, drowsiness, headache, swollen, tender gums, decreased appetite, reddened eyes, hair loss, confusion, weakness, or difficulty moving one or both sides of the body, loss of consciousness.


Ask your doctor or pharmacist for more information. Inform your doctor right away if you take any of the following medications: nonsteroidal anti-inflammatory drugs (NSAIDS), such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), or salsalate; acitretin (Soriatane), azathioprine ( Inform your doctor about all of the medications you take, including vitamins, herbal supplements, prescription and non-prescription drugs.


Elderly people, newborns, people with kidney or liver disease, and bone marrow depression. Monitor haematological, renal and hepatic function, and GI toxicity regularly. Ulcerative disorders of the GI tract.

How methotrexate works?

How Methotrexate Works to Help Fight Inflammation. Methotrexate is thought to work by causing cells to release a molecule that block chemicals that promote inflammation, according to the Arthritis Foundation. Reducing inflammation helps prevent pain and joint damage otherwise experienced by people with the disease.

Does methotrexate increase the risk of cervical cancer?

There is no evidence that methotrexate increases the risk of developing cervical cancer.

Is 25mg of methotrexate a lot?

The correct dose of methotrexate (commonly between 7.5mg to 25mg per week) will reduce inflammation and alleviate the condition it's prescribed for, whether that's rheumatoid arthritis, psoriasis, inflammatory bowel disease, and so on.

How long does it take to work?

Methotrexate can start working for rheumatoid arthritis within 3 to 6 weeks and symptoms continue to improve over 3 months. For other people it might take a few months before they notice any improvement in their rheumatoid arthritis symptoms.

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Jayden Hartley Oct 18, 2022, 10:20:38 PM

The cyclophosphamide dose was either a 500 mg/minjection every month or a 1-2 mg pill every day. This causes high levels of inflammation that lead to scar tissue building up in the skin. Sixty-five patients received 20 to 25 mg of methotrexate a week, while 118 received up to 1 g of CellCept (mycophenolate mofetil) twice a day, and 87 received cyclophosphamide. Another group of 56 patients did not receive any immunosuppressants for their scleroderma, although some were on steroid treatments.

jayiitb May 23, 2019, 2:10:06 PM

Mechanistically, histidine catabolism drains the cellular pool of tetrahydrofolate, which is particularly detrimental to methotrexate-treated cells. Although methotrexate is widely used as an anticancer agent and is the subject of over a thousand ongoing clinical trials, its high toxicity often leads to the premature termination of its use, which reduces its potential efficacy. The histidine degradation pathway markedly influences the sensitivity of cancer cells to methotrexate and may be exploited to improve methotrexate efficacy through a simple dietary intervention. This screen yielded FTCD, which encodes an enzyme—formimidoyltransferase cyclodeaminase—that is required for the catabolism of the amino acid histidine, a process that has not previously been linked to methotrexate sensitivity.

Ben Hummel Apr 15, 2010, 6:42:07 AM

These drugs are often used to treat similar conditions. This helps to treat the symptoms of psoriasis, which include dry, itchy patches of skin. Methotrexate self-injectable solution may be used as part of a combination therapy. It’s believed that methotrexate weakens your immune system, which may help reduce pain, swelling, and stiffness from RA. For psoriasis, methotrexate slows down how fast your body produces the top layer of your skin.

Rochelle Eskue Dec 26, 2012, 8:05:16 AM

Methotrexate continues to remain a highly effective drug in the treatment of cancer and autoimmune disorders. Clinical Pharmacology When we talk about the clinical pharmacology of methotrexate, we need to think about the following factors: Methotrexate must be taken once weekly. Methotrexate should be avoided in patients with hepatic dysfunction. Folinic acid is used to reverse the effects of methotrexate in overdose.

Rayyan Tomali Jun 30, 2022, 1:25:12 PM

This increases the risk of severe infections and other blood disorders. Typically, folic acid is given alongside methotrexate treatment – taken on a different day of the week (often recommended the day after methotrexate treatment). There are two primary modes of action with methotrexate: First, methotrexate inhibits dihydrofolate reductase (DHFR), an enzyme that plays a role in converting dihydrofolate to the active tetrahydrofolate (THF).

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