Side effects
If you experience any strange side effects while taking this medication, call your doctor right away. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Medroxyprogesterone may raise a person's risk of developing breast cancer, but this is unknown. Additionally, medroxyprogesterone may raise your risk of developing a blood clot that travels to your lungs or brain. Other side effects of medroxyprogesterone are possible. There could be side effects from medroxyprogesterone. Talk to your doctor about the risks of taking this medication. Inform your physician if any of these symptoms persist or are severe, including tender or liquid-producing breasts, changes in menstrual flow, irregular vaginal bleeding or spotting, acne, difficulty falling or staying asleep, drowsiness, weight gain or loss, pain, swelling, warmth, redness, or tenderness in just one leg, slow or difficult speech, dizziness or faintness, or weakness or numbness in an arm or leg. The following symptoms are rare, but if you experience any of them, call your doctor right away: tender or liquid-producing breasts changes in menstrual flow irregular vaginal bleeding or spotting acne growth of hair on the face hair loss of hair on the scalp difficulty falling asleep or staying asleep drowsiness upset stomach weight gain or loss pain, swelling, warmth, redness, or tenderness in one leg only slow or difficult speech dizziness or faintness weakness or nubility
Interactions
Drug interactions involving medroxyprogesterone (more information) Other drugs may interact with medroxyprogesterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician of all other medications you take.
Contraindications
Because of these risks, combination HT should only be used short-term at the lowest possible dose. Do not start taking medroxyprogesterone if you: have undiagnosed vaginal bleeding. currently have or have had certain cancers. To avoid heart disease, heart attacks, or strokes, avoid using estrogens, whether they are combined with progestins or not. The combination of estrogen and progestin may increase your risk of developing some cancers, including breast cancer. Consult your doctor before using medroxyprogesterone if you have or have ever had cancer, have had a stroke or heart attack within the past year, have blood clots now or ever, have liver issues now or ever, or suspect you may be pregnant. Medroxyprogesterone should not be used as a pregnancy test, if you are allergic to any of the ingredients in medroxyprogesterone, or if you take it and later discover you were pregnant while taking it, be sure to talk to your doctor as soon as possible. Your risk of osteoporosis (weak and thinning bones) and fractures may increase as a result of medroxyprogesterone injection-induced bone loss. Combination hormone therapy, or HT (estrogen and progesterone), has been linked in studies to an increased risk of blood clots, dementia, breast cancer, and heart attacks. If you believe you might be pregnant or experiencing a miscarriage, let your healthcare provider know right away. The medication should not be used for longer than two years unless absolutely necessary as long-term therapy will increase risk of bone loss. When mothers use this medication during the first four months of pregnancy, there may be an increased risk of mild birth defects in the fetus. Your risk of heart attacks, strokes, breast cancer, and blood clots may rise if you use estrogens, progestins, or both. According to a study of women aged 65 and older, taking estrogens either with or without progestins may increase your risk of developing dementia. After menopause, vaginal bleeding might be an indication that the uterus (womb) has cancer. You and your healthcare provider should talk regularly about whether you still need treatment with medroxyprogesterone. To determine the cause of any unusual vaginal bleeding, consult with your doctor.
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When the medication is working and your condition stops getting worse, your doctor may direct you to have your injections less often, such as once a month.Use this medication regularly in order to get the most benefit from it. HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using medroxyprogesterone and each time you get a refill. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects.
Tell your doctor if any of these symptoms are severe or do not go away: Breasts that are tender or produce a liquid Changes in menstrual flow Irregular vaginal bleeding or spotting Acne Growth of hair on face Loss of hair on scalp Difficulty falling asleep or staying asleep Drowsiness Upset stomach Weight gain or loss Some side effects can be serious. Talk to your doctor about the risks of taking this medication. Medroxyprogesterone may also increase the chance that you will develop a blood clot that moves to your lungs or brain. Call your doctor if you have any unusual problems while taking this medication. It is not known if medroxyprogesterone increases the risk of breast cancer in humans.
People with diabetes may experience difficulty controlling blood glucose when taking medroxyprogesterone for unclear reasons. The Women's Health Initiative (WHI) study found an increased risk of heart attacks, stroke, breast cancer, blood clots, and pulmonary emboli (blood clots that lodge in the lungs) in postmenopausal women (50 to 79 years of age) who took medroxyprogesterone in combination with estrogens for 5 years, as well as an increased risk of dementia in the women over age 65. Therefore, females requiring progestin therapy are strongly encouraged to quit smoking. Although medroxyprogesterone alone has not been demonstrated to promote breast cancer, since breast cancer has progesterone receptors, physicians usually avoid using progestins in women who have had breast cancer. Blood clots are an occasional serious side effect of progestin therapy, and cigarette smokers are at a higher risk for clots.
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