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medroxyprogesterone side effects

It functions by preventing the uterine lining from growing and by causing the uterus to produce specific hormones. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Additionally, medroxyprogesterone is used to treat patients who are taking estrogen to prevent the uterine lining from growing too much and may lower their risk of developing uterine cancer. Progestins are a group of drugs that includes medroxyprogesterone. Periods that are abnormal or irregular vaginal bleeding are treated with medroxyprogesterone.

Other names for this medication:
Prempro 0.625/2.5 28 Day, Provera, Depo-Provera, Depo-Subq Provera, Premphase 28 Day

Similar Products:
Cabergoline, Mircette, Arimidex, Estrace, Dydrogesterone, Caberlin, Alendronate, Fosamax, Norethindrone, Prometrium, Levonorgestrel, Tamoxifen, Duphaston, Ovral, Clomid


For more information, speak with your doctor or pharmacist. The injectable form of medroxyprogesterone is also used to relieve the symptoms of advanced endometrial cancer, long-acting birth control, endometriosis pain (subcutaneous form), and kidney cancer (intramuscular form), among other conditions. Indications for the prescription drug medroxyprogesterone (oral) include treating irregular uterine bleeding or menstrual periods that have stopped, as well as lowering the risk of uterine cancer in postmenopausal women.


Even if you feel good, keep taking medroxyprogesterone on the scheduled monthly basis. Do not stop taking medroxyprogesterone without talking to your doctor. Never take it in larger or smaller amounts or more frequently than your doctor has instructed. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. It is usually taken once a day on certain days of a regular monthly cycle. Medroxyprogesterone is available as a tablet that needs to be swallowed. Your condition may be controlled but not cured by medroxyprogesterone. Follow the prescription for medroxyprogesterone exactly. Ask your doctor or pharmacist for more details if you think this medication may be prescribed for other conditions. Medroxyprogesterone should be taken on the days you are supposed to take it at roughly the same time each day to help you remember to take it. Continue eating normally unless your doctor instructs you otherwise.

Missed dose

Never take two doses at once to make up for missed ones. If the next dose is almost due, skip the missed one and carry on with your regular dosing schedule. When you remember, immediately take the missed dose.


Call 1-800-222-1222 for poison help if you need immediate medical attention.


You shouldn't flush this medication down the toilet, though. Instead, the best way to dispose of your medication is through a medicine take-back program. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Always lock safety caps and immediately stow medication up and away, out of sight, and away from reach of young children to prevent poisoning. In order to prevent pets, kids, and other people from ingesting leftover medications, they should be disposed of in a specific manner.

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Side effects

If you experience any strange side effects while taking this medication, call your doctor right away. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088). Medroxyprogesterone may raise a person's risk of developing breast cancer, but this is unknown. Additionally, medroxyprogesterone may raise your risk of developing a blood clot that travels to your lungs or brain. Other side effects of medroxyprogesterone are possible. There could be side effects from medroxyprogesterone. Talk to your doctor about the risks of taking this medication. Inform your physician if any of these symptoms persist or are severe, including tender or liquid-producing breasts, changes in menstrual flow, irregular vaginal bleeding or spotting, acne, difficulty falling or staying asleep, drowsiness, weight gain or loss, pain, swelling, warmth, redness, or tenderness in just one leg, slow or difficult speech, dizziness or faintness, or weakness or numbness in an arm or leg. The following symptoms are rare, but if you experience any of them, call your doctor right away: tender or liquid-producing breasts changes in menstrual flow irregular vaginal bleeding or spotting acne growth of hair on the face hair loss of hair on the scalp difficulty falling asleep or staying asleep drowsiness upset stomach weight gain or loss pain, swelling, warmth, redness, or tenderness in one leg only slow or difficult speech dizziness or faintness weakness or nubility


Drug interactions involving medroxyprogesterone (more information) Other drugs may interact with medroxyprogesterone, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician of all other medications you take.


Because of these risks, combination HT should only be used short-term at the lowest possible dose. Do not start taking medroxyprogesterone if you: have undiagnosed vaginal bleeding. currently have or have had certain cancers. To avoid heart disease, heart attacks, or strokes, avoid using estrogens, whether they are combined with progestins or not. The combination of estrogen and progestin may increase your risk of developing some cancers, including breast cancer. Consult your doctor before using medroxyprogesterone if you have or have ever had cancer, have had a stroke or heart attack within the past year, have blood clots now or ever, have liver issues now or ever, or suspect you may be pregnant. Medroxyprogesterone should not be used as a pregnancy test, if you are allergic to any of the ingredients in medroxyprogesterone, or if you take it and later discover you were pregnant while taking it, be sure to talk to your doctor as soon as possible. Your risk of osteoporosis (weak and thinning bones) and fractures may increase as a result of medroxyprogesterone injection-induced bone loss. Combination hormone therapy, or HT (estrogen and progesterone), has been linked in studies to an increased risk of blood clots, dementia, breast cancer, and heart attacks. If you believe you might be pregnant or experiencing a miscarriage, let your healthcare provider know right away. The medication should not be used for longer than two years unless absolutely necessary as long-term therapy will increase risk of bone loss. When mothers use this medication during the first four months of pregnancy, there may be an increased risk of mild birth defects in the fetus. Your risk of heart attacks, strokes, breast cancer, and blood clots may rise if you use estrogens, progestins, or both. According to a study of women aged 65 and older, taking estrogens either with or without progestins may increase your risk of developing dementia. After menopause, vaginal bleeding might be an indication that the uterus (womb) has cancer. You and your healthcare provider should talk regularly about whether you still need treatment with medroxyprogesterone. To determine the cause of any unusual vaginal bleeding, consult with your doctor.

What is the side effect of medroxyprogesterone?

Nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness, drowsiness, or weight gain/loss may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.

Is medroxyprogesterone acetate the same as medroxyprogesterone?

Medroxyprogesterone acetate is a type of hormonal therapy drug. It is also called Provera or Depo-Provera.

What is medroxyprogesterone tablets used for?

Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens.

What is medroxyprogesterone used for?

Medroxyprogesterone is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding. It is also used to prevent endometrial hyperplasia (thickening of the lining of the uterus or womb) in women who are taking conjugated estrogens. This medicine is a progestin hormone.

Does medroxyprogesterone increase chances of pregnancy?

Studies though have not found that Medroxyprogesterone is responsible for an increased chance for ectopic pregnancy or a miscarriage. There are studies though that have shown there may be a link between certain birth defects in mothers exposed to progestins in the first trimester of pregnancy.

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macmur Mar 1, 2014, 4:42:40 PM

Send us enquiry for Medroxyprogesterone acetate powder price if you are looking for suppliers online. Inopha is supplier of GMP quality Medroxyprogesterone acetate API, a type of female hormone medicine used as a method of birth control and as a part of menopausal hormone therapy.

Robin Surgeoner Dec 9, 2020, 2:42:15 AM

When the medication is working and your condition stops getting worse, your doctor may direct you to have your injections less often, such as once a month.Use this medication regularly in order to get the most benefit from it. HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using medroxyprogesterone and each time you get a refill. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects.

Roie R Jun 19, 2012, 9:34:04 AM

Tell your doctor if any of these symptoms are severe or do not go away: Breasts that are tender or produce a liquid Changes in menstrual flow Irregular vaginal bleeding or spotting Acne Growth of hair on face Loss of hair on scalp Difficulty falling asleep or staying asleep Drowsiness Upset stomach Weight gain or loss Some side effects can be serious. Talk to your doctor about the risks of taking this medication. Medroxyprogesterone may also increase the chance that you will develop a blood clot that moves to your lungs or brain. Call your doctor if you have any unusual problems while taking this medication. It is not known if medroxyprogesterone increases the risk of breast cancer in humans.

Lewis Diamond Jun 22, 2020, 7:39:40 PM

People with diabetes may experience difficulty controlling blood glucose when taking medroxyprogesterone for unclear reasons. The Women's Health Initiative (WHI) study found an increased risk of heart attacks, stroke, breast cancer, blood clots, and pulmonary emboli (blood clots that lodge in the lungs) in postmenopausal women (50 to 79 years of age) who took medroxyprogesterone in combination with estrogens for 5 years, as well as an increased risk of dementia in the women over age 65. Therefore, females requiring progestin therapy are strongly encouraged to quit smoking. Although medroxyprogesterone alone has not been demonstrated to promote breast cancer, since breast cancer has progesterone receptors, physicians usually avoid using progestins in women who have had breast cancer. Blood clots are an occasional serious side effect of progestin therapy, and cigarette smokers are at a higher risk for clots.

deMangler Dec 19, 2011, 4:47:28 AM

Progestin-only birth control is not a cause of infertility. Depot medroxyprogesterone acetate (Depo-Provera) is a form of birth control that is given as a shot ... More Answers can progestin-only birth control cause infertility ? The following drugs may cause hormonal birth control methods (including medroxyprogesterone injectio ... More Answers how do oral contraceptives affect uterine fibroids ? However, if you have been on long-acting ... More Answers do any drugs interact with medroxyprogesterone injections ?

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