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Mebendazole
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mebendazole bnf interactions

An anthelmintic called mebendazole is a benzimidazole that is used to treat helminth infections.

Other names for this medication:
Vermox, Emverm

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Tolterodine, Urso, Albendazole, Levodopa, Requip, Levothyroxine, Diaminodiphenyl, Albenza, Nevirapine, Diamox, Flexeril, Levothroid, Eldepryl, Dulcolax, Reminyl, Ticlid, Revia

Description

The production of adenosine triphosphate (ATP), which is necessary for the helminth's survival, is reduced as a result of degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the release of lysosomes that follows. The parasite becomes immobile and eventually perishes as a result of reduced energy production. By attaching to the colchicine-sensitive site of tubulin and preventing it from polymerizing or assembling into microtubules, mebendazole impairs the worm's tegument and intestinal cells. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores.

Dosage

Carefully adhere to the instructions on your prescription label. Adhere strictly to your doctor's instructions when taking mebendazole. The Mebendazole dose your doctor recommends will be based on the following (use any or all that apply): the condition being treated other medical conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender Mebendazole is available in the following doses: Mebendazole 100 Mg Oral Tablet, Chewable Mebendazole Compounding Powder

Missed dose

Do not take a double dose to make up for a missed one. If the next dose is almost due, skip the missed one and carry on with your regular dosing schedule. If you miss a dose, take it as soon as you remember.

Overdose

Upper stomach pain, anorexia, dark urine, or jaundice (yellowing of the skin or eyes) are some overdose symptoms that can occur. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

This medication should not, however, be flushed down the toilet. Instead, using a medication take-back program is the best way to get rid of your medication. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication tightly closed in the original container and out of the reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and put medication in a secure spot right away that is up and out of the way and out of reach of young children to prevent poisoning. http://www.upandaway.org Unneeded medications should be disposed of in a specific manner to prevent pets, kids, and other people from eating them.

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Side effects

If you experience any unusual issues while taking this medication, contact your doctor right away. The Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program is available online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you or your doctor notice a serious side effect. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment: diarrhea stomach pain, discomfort, or swelling nausea vomiting loss of appetite seizures rash hives shortness of breath difficulty breathing or swallowing fever, sore throat, chills, or other signs of infection Mebendazole may cause other side effects. Negative effects from mebendazole could occur. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea stomach pain, discomfort, or swelling nausea vomiting loss of appetite seizures rash hives shortness of breath difficulty breathing or swallowing fever, sore throat, chills, or other signs of infection Some side effects can be serious.

Interactions

Threadworms, whipworms, roundworms, and hookworms can all be treated with mebendazole.

Contraindications

Inform your doctor and pharmacist about any other prescription and non-prescription drugs, vitamins, or dietary supplements you are taking or intend to take by asking for a list of the ingredients in the product. Make sure to carefully adhere to the directions given by your doctor. Cimetidine (Tagamet) and metronidazole (Flagyl, in Pylera) should both be mentioned. Before taking mebendazole, tell your doctor and pharmacist if you are allergic to mebendazole, any other medications, or any of the ingredients in mebendazole chewable tablets. You should call your doctor if you become pregnant while taking mebendazole because you'll also need to take precautions to avoid reinfection and spreading the infection to others, in addition to your mebendazole treatment. Speak with your doctor about additional steps you can take to stop the spread of the infection and reinfection. In particular, after using the bathroom and before eating, you should frequently wash your hands and fingernails with soap. If you have or have ever had stomach or liver disease, let your doctor know. Let your doctor know if you are pregnant, intend to become pregnant, or are nursing. Your doctor may need to monitor you carefully for side effects.

Why is mebendazole discontinued?

7. Why is Mebendazole discontinued? Mebendazole was discontinued in 2011 due to the poor tissue penetration of Mebendazole and the current availability of albendazole and not for safety or efficacy reasons, stated by the Federal Register determination.

How does it work?

Mebendazole kills worms that cause gut infections such as threadworm (sometimes known as pinworm) and other less common worm infections (whipworm, roundworm and hookworm). It works by stopping the worms using sugar (glucose). Without glucose, the cells of the worms lose their energy supply and quickly die. Mebendazole does not kill the eggs of the worm. This is why you may need to take another dose 2 weeks later to help prevent reinfection.

Can I drive or ride a bike?

Yes. Mebendazole shouldn't affect you being able to drive or cycle.

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Testimonials
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Leticia Poschi Apr 21, 2017, 5:52:07 AM

Mohamed Diabakhate Mar 17, 2012, 6:41:28 PM

Fascioliasis is endemic in 61 countries and has become a foodborne infection of public importance in areas of the world such as the Andean highlands of Bolivia, Ecuador, and Peru, the Nile delta of Egypt, and northern Iran. It was not used in humans until the 1989 epidemic of fascioliasis near the Caspian Sea when Iranian authorities approved the use of the veterinary formulation to treat the infection. Humans are accidental hosts; infection results from eating uncooked, and usually unwashed, aquatic vegetables [e.g., watercress] contaminated with encysted parasitic larvae. It differs from the other benzimidazole anthelmintics (e.g., albendazole, mebendazole) currently used in humans since these compounds have selective activity against nematodes and have no significant activity against flukes and other trematode helminths. Triclabendazole API CAS: 68786-66-3 • Information: Triclabendazole is a benzimidazole class anthelminthic agent used for the control of liver fluke infestation in sheep, goats and cattle.

Lhh92 Apr 4, 2013, 6:48:55 PM

Follow all instructions of your doctor about treatment, washing of linens, clothing, and towels as pinworm infections are easily spread from one person to another. Seek medical attention immediately if an overdose is suspected. If you miss a dose, use it as soon as you remember.

kalai MV Aug 11, 2018, 12:46:28 PM

Product Packaging – The dosages available for this product are: • Mebendazole tablets 100mg Mebendazole tablets 500mg Mebendazole tablets may be packaged as 10 tablets/blister, 10 blisters/box or as per customer specification. Mebendazole Tablet • Product Information: Mebendazole tablets are indicated for the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections. Efficacy varies as a function of such factors as pre-existing diarrhea and gastrointestinal transit time, degree of infection, and helminth strains.

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