Side effects
If you have: For medical advice about side effects, contact your doctor. Typical negative effects could be: If you experience hives, breathing difficulties, swelling of your face, lips, tongue, or throat, you should seek emergency medical attention. Loxapine can cause a serious movement disorder that might not be reversible in response to high doses or prolonged use. Loxapine side effects (more detail) In particular if you are a woman or an older adult, the longer you use loxapine, the greater the chance you have of developing this disorder. There may be additional side effects not included in this list. Contact the FDA at 1-800-FDA-1088 to report side effects. dizziness, problems with balance or walking; swelling in your face; itching or rash; tremors, muscle twitching or stiffness; numbness, weakness; blurred vision; feeling restless or agitated; nausea, vomiting, constipation; dry mouth, stuffy nose; or insomnia. Uncontrollable muscle movements in your arms, legs, or face, such as chewing, lip-smacking, frowning, tongue movement, blinking, or eye movement; a rapid heartbeat; a light-headed sensation, as if you might pass out; confusion, slurred speech; agitation; trouble sleeping; seizures; little to no urination; severe constipation; low white blood cell counts—fever, chills, mouth sores, skin sores
Interactions
Especially tell your healthcare provider if you take: alcohol opioid analgesics benzodiazepines tricyclic antidepressants general anesthetics phenothiazines sedative/hypnotics muscle relaxants illicit CNS depressants Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. When you receive a new medication, keep a list of them to show your doctor and pharmacist. Know the medications you take. Loxapine and other medicines may affect each other causing side effects. Both loxapine and other medications may have an impact on one another's functionality. In addition to vitamins and herbal supplements, make sure your doctor is aware of all medications you are taking, both prescription and over-the-counter.
Contraindications
When taking Loxapine, avoid drinking alcohol. If you are allergic to loxapine, drugs that are similar to it, or any of the inactive ingredients, do not take it. Do not take loxapine if you have or have ever had asthma, chronic obstructive pulmonary disease (COPD), or any other lung or airway conditions that can cause bronchospasm; if you experience wheezing, coughing, chest tightness, or shortness of breath; if you are taking medications to treat asthma or COPD; if you have ever taken loxapine and experienced bronchospasm; or if you are allergic to lox increased risk of death in elderly patients with dementia-related psychosis. Inhalation: A Risk Evaluation and Mitigation (REMS) Program is the only way to obtain loxapine. Your likelihood of experiencing severe side effects may increase. Patients with psychosis associated with dementia cannot be treated with loxapine. Loxapine may have serious side effects, such as bronchospasm, a narrowing of the airways that can make breathing difficult or impossible. Drugs like loxapine can increase the risk of death in elderly patients who have dementia-related confusion and psychosis (loss of reality). Despite being uncommon, neuroleptic malignant syndrome (NMS) is a serious condition that can be fatal. Loxapine may have serious side effects, such as tardive dyskinesia (TD), when taken orally or inhaled. When taking loxapine, people with asthma or other airway or lung conditions, such as chronic obstructive pulmonary disease (COPD), are more likely to experience bronchospasms. If you experience any of these NMS symptoms after taking loxapine, contact your doctor immediately. high fever, stiff muscles, confusion, sweating, low blood pressure (hypotension), lightheadedness, or fainting seizures (convulsions), extreme sleepiness and difficulty with potentially hazardous activities like driving, worsening of glaucoma, difficulty urinating, and changes in pulse, heart rate, and blood pressure Tell your doctor right away if you experience any of these bronchospasm symptoms after taking loxapine. Bronchospasm symptoms can include wheezing, coughing, chest tightness, and shortness of breath. Among the side effects of TD are tremors, sudden and excruciating muscle stiffness, restlessness, and a slowing down of all body muscles. The healthcare facility must be enrolled in this program before you can be given loxapine. Following a decade of loxapine use, these side effects may start to appear. Before and after you take loxapine, your doctor should examine you for breathing issues.
Injections of medications can be considered by some as coercive and invasive, reducing patient autonomy and damaging the doctor–patient therapeutic relationship. Roberts J, Gracia Canales A, Blanthorn-Hazell S, Craciun Boldeanu A, Judge D. Characterizing the experience of agitation in patients with bipolar disorder and schizophrenia. Additionally, participants that received placebo required an additional dose for persistent or recurrent agitation sooner than those taking inhaled loxapine.
It was launched in 2003 in Spain under the brand name of Rupafin. However, as in other non sedating second-generation antihistamines, the most common side effects in controlled clinical studies were somnolence, headaches and fatigue. 1 Medical uses 2 Side effects 3 Pharmacology 3.1 Mechanism of action 3.2 Pharmacokinetics 4 History 5 Brand names 6 References 7 External links Rupatadine fumarate has been approved for the treatment of allergic rhinitis and chronic urticaria in adults and children over 12 years.
It has negligible affinity for the serotonin transporter, dopamine transporter, α-adrenergic receptor, and muscarinic acetylcholine receptors. Whether it has any antagonistic effects on the 5-HT, 5-HT, or D receptors like its relative maprotiline is unclear. 1 Pharmacology 2 Chemistry 3 See also 4 References Dextroprotiline acts as a potent norepinephrine reuptake inhibitor and H receptor antagonist, as well as a very weak α-adrenergic receptor antagonist.
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Black Box Warnings Patients with dementia-related psychosis who are treated with antipsychotic drugs are at an increased risk of death as shown in short-term controlled trials.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Hydroxyethylpromethazine&oldid=1082638530" Categories: H1 receptor antagonists Muscarinic antagonists Phenothiazines Quaternary ammonium compounds Primary alcohols Respiratory system drug stubs Hidden categories: Articles with short description Short description matches Wikidata Articles without EBI source Chemical pages without DrugBank identifier Articles without KEGG source Drugs with no legal status Drugboxes which contain changes to watched fields All stub articles Jump to navigation Jump to search N-(2-hydroxyethyl)-N,N-dimethyl-1-(10H- • phenothiazin-10-yl)propan-2-aminium InChI=1S/C19H25N2OS/c1-15(21(2,3)12-13-22)14-20-16-8-4-6-10-18(16)23-19-11-7-5-9-17(19)20/h4-11,15,22H,12-14H2,1-3H3/q+1 Hydroxyethylpromethazine is an antihistamine with anticholinergic properties.
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