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Loratadine
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loratadine bnf pregnancy

CNS effects are less with loratadine compared to the traditional sedating antihistamines; not associated with QT prolongation nonsedating antihistamine for oral use Used for allergic rhinitis, chronic idiopathic urticaria, or other allergic symptoms in both adult and pediatric populations

Other names for this medication:
Claritin-D, Wal-Itin, Loradamed, Wal-Itin D, Alavert D, Claritin, Allerclear, Alavert

Similar Products:
Montelukast, Cyproheptadine, Combivent, Duolin, Periactin, Desloratadine, Budesonide, Hydroxyzine, Levolin, Clarinex, Pulmicort

Description

Loratadine is selective for peripheral H1 receptors, just like other 2nd generation antihistamines. Loratadine does not penetrate effectively into the central nervous system and has poor affinity for CNS H1-receptors. As a result, these characteristics prevent CNS depressant effects like drowsiness, sedation, and impaired psychomotor function from occurring.

Dosage

One Loratadine tablet once a day for adults and kids over 12 years old. Loratadine tablets should not be used in children under the age of 2 because their safety and effectiveness have not been proven. Children ages 2 to 12 should take one Loratadine tablet once daily if they weigh over 30 kg and half a tablet if they weigh less than 30 kg. Typically, it is given first thing in the morning or whenever symptoms call for medical attention.

Missed dose

Never take two doses at once to make up for missed ones. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. As soon as you remember, take the missed dose.

Overdose

Call emergency services at 911 right away if the victim has fallen, experienced a seizure, is having trouble breathing, or cannot be roused. In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. Overdose signs and symptoms can include a racing or pounding heartbeat, drowsiness, headaches, and unusual body movements.

Storage

However, you should not flush this medication down the toilet. The best way to get rid of your medication is instead through a medication take-back program. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Keep this medication out of the reach of children and tightly closed in the original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more information. Store it at room temperature, away from strong light, moisture, and heat (not in the bathroom). For information on take-back programs in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city. Always lock safety caps and immediately put the medication in a safe place, one that is up and away and out of their sight and reach. http://www.upandaway.org Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Use the orally disintegrating tablets within six months of opening the outer foil pouch and as soon as you take them out of the blister package. To keep track of when six months have passed, mark the date you opened the foil pouch on the product label.

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Side effects

Call your doctor right away if you experience any of the following symptoms and stop taking loratadine: headache dry mouth nosebleed sore throat mouth sores difficulty falling or staying asleep nervousness weakness stomach pain diarrhea red or itchy eyes rash hives itching swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs hoarseness difficulty breathing or swallowing wheezing A side effect of loratadine could be. Inform your doctor if any of these side effects persist or become severe, including: headache, dry mouth, nosebleed, sore throat, mouth sores, difficulty falling or staying asleep, nervousness, weakness, diarrhea, stomach pain, rash, itching, swelling of the hands, arms, feet, ankles, or lower legs, hoarseness, and wheezing. Some side effects may be serious.

Interactions

Loratadine tablets are recommended for use in children older than 2 years old to treat the symptoms of seasonal allergic rhinitis and allergic skin conditions like urticaria and nettle rash. Sneezing, nasal discharge, itching, ocular itching, and burning are also among the allergic rhinitis symptoms that it effectively treats. Also recommended for idiopathic urticaria is the loratadine tablet. The symptoms of seasonal allergic rhinitis, perennial allergic rhinitis, and skin allergies, including chronic urticaria, can be quickly and effectively relieved by loratadine tablets. After oral administration, nasal and ocular signs and symptoms are quickly relieved.

Contraindications

Mention any allergy and cold medications you may be taking, let your doctor know if you have or have ever had asthma, kidney or liver disease, are pregnant, plan to become pregnant, or are nursing. Inform your doctor and pharmacist if you have any medication allergies or if you have any other allergies before taking loratadine. Check the package label for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Call your doctor if you become pregnant while taking loratadine. If you have phenylketonuria (PKU), an inherited condition that requires adherence to a special diet in order to prevent brain damage that could result in severe intellectual disability, you should be aware that some brands of the orally disintegrating tablets may contain aspartame, which converts to phenylalanine.

Can I drive or ride a bike with it?

Loratadine is classed as a non-drowsy antihistamine but it's still possible to feel sleepy after taking it. If this happens to you, do not drive a car or ride a bike until you feel better. It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive. Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking loratadine. GOV.UK has more information on the law on drugs and driving.

When will I feel better?

You should start to feel better within an hour.

Can I take 2 different antihistamines together?

Sometimes, doctors recommend that people with a severe, itchy skin rash take 2 different antihistamines together for a few days. As well as taking a non-drowsy antihistamine like loratadine during the day, your doctor may tell you to take a sedating antihistamine at night if the itching is making it difficult to sleep. Do not take 2 antihistamines together unless recommended by your doctor.

What is LORATADINE used for?

Loratadine is an antihistamine medicine that helps with the symptoms of allergies. It's used to treat: hay fever. conjunctivitis (red, itchy eyes)

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Testimonials
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Iftikhar Hossain Jun 2, 2015, 1:54:43 AM

However, it’s very useful to get a quick overview of each treatment — especially if you’re deciding between two in particular. We will also cover the difference between Desloratadine and some other non-drowsy antihistamines below. However, both active ingredients work in a very similar way to relieve allergy symptoms.

Nataliia Kropachova Aug 3, 2019, 9:21:15 AM

The most frequent adverse reactions reported in excess of placebo were somnolence (1.2%), headache (0.6%), increased appetite (0.5%) and insomnia (0.1%). In clinical trials involving adults and adolescents in a range of indications including AR and CIU, at the recommended dose of 10 mg daily, adverse reactions with loratadine were reported in 2% of patients in excess of those treated with placebo. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Edward Yang Sep 25, 2012, 10:22:14 AM

user3750355 Feb 25, 2017, 8:58:14 AM

The terminal half-life of pseudoephedrine from the combination tablet administered twice daily was 6.3 hours (23). This product, due to its pseudoephedrine component, is contraindicated in patients with narrow-angle glaucoma or urinary retention, and in patients receiving monoamine oxidase (MAO) inhibitor therapy or within fourteen (14) days of stopping such treatment (see DRUG INTERACTIONS). Because the doses of this fixed combination product cannot be individually titrated and hepatic insufficiency results in a reduced clearance of loratadine to a much greater extent than pseudoephedrine, loratadine; pseudoephedrine sulfate extended release tablets should generally be avoided in patients with hepatic insufficiency. In a single-dose study, food increased the AUC of loratadine by approximately 40% and of descarboethoxyloratadine by approximately 15%.

Elias Hatzinikitas Dec 30, 2011, 5:15:43 PM

Hence it proved effective and tolerable to the symptoms of allergies.Cetirizine comes under the brand Zyrtec, and loratadine comes under Claritin. Both Cetirizine and loratadine have similar uses, but the drug also depends on the conditions, some people feel drowsiness by taking Cetirizine, but it depends on the person. The children were studied parallelly and were monitored by the experts; they were given about 0.2mg/kg per day in the morning both the drug for 28 days; on the 28th day, the results displayed in which Cetirizine was proven significantly more significant as compared to loratadine. A study was conducted about the effectiveness of Cetirizine and loratadine. The study was born on 80 children aged 2 to 6 years with rhinitis allergies caused by house dust and plant pollens.

Alex Burger Feb 15, 2013, 6:43:05 AM

It is often a misconception that new drugs are more beneficial than their predecessors. The safety and efficacy of desloratadine is virtually identical to that of loratadine, the current formulary agent. This will likely decrease loratadine’s price by 50% or more.

KBH Sep 22, 2019, 10:12:30 PM

Moreover, taking indigestion remedies (antacids) two hours before, during, or after you use this medicine, can notably lower the amount of drug the body absorbs. This medicine is on the WHO’s List of Essential Medicines. In addition, it helps relieve a type of itchy skin rash with the medical term of chronic idiopathic urticaria. Currently, it is sold under the brand name Claritin, manufactured by Bayer Healthcare.

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