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Linezolid
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inj linezolid dose

For viral infections like the flu, colds, and other contagious diseases, antibiotics like linezolid are ineffective. Bacterial growth is halted, and this is how it functions. The antibiotic linezolid belongs to the oxazolidinones class of antibacterials. Skin infections and pneumonia are both treated with linezolid. Antibiotic overuse increases the likelihood that you'll develop an infection later on that is resistant to antibiotic treatment.

Other names for this medication:
Zyvoxam, Zyvox

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Description

If the pathogens are known or presumed to exist, combination therapy may be clinically indicated. Community-acquired pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains) including cases with concurrent bacteremia or Staphylococcus aureus (methicillin-susceptible strains only). Infections of the skin and skin structures that are complicated, such as infections of the diabetic foot (without concurrent osteomyelitis) brought on by Staphylococcus aureus (methicillin-susceptible and methicillin-resistant),... Complicated skin and skin structure infections, including diabetic foot infections (without concomitant osteomyelitis) caused by Staphylococcus aureus (methicillin-susceptible and methicillin-resistant strains), Streptococcus pyogenes or Streptococcus agalactiae. Nosocomial pneumonia brought on by multi-drug resistant strains of Streptococcus pneumoniae or methicillin-susceptible and resistant strains of Staphylococcus aureus. Read more about infections caused by vancomycin-resistant Enterococcus faecium, including instances of concomitant bacteremia. Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible only) or Streptococcus pyogenes. infections with vancomycin-resistant Enterococcus faecium, including instances where bacteremia is present.

Dosage

When taking linezolid, keep tyramine-containing foods and beverages to a minimum. Turn the bottle over three to five times to gently mix the oral suspension before using. Children under the age of 11 typically take linezolid two to three times per day (every 8 to 12 hours) for a period of 10 to 28 days, with or without food. Keep the suspension from shaking. Without consulting your doctor, do not stop taking linezolid. Take it only as directed by your doctor, neither more nor less than that amount or more frequently. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow them. Tyramine is typically present in pickled, smoked, or fermented foods and drinks. Your infection might not be completely treated if you stop taking linezolid too soon or if you skip doses, and the bacteria might develop an antibiotic resistance. It is usually taken with or without food twice a day (every 12 hours) for 10 to 28 days. Linezolid comes as a tablet and oral suspension (liquid) to take by mouth. Just as it is prescribed, take linezolid. Even if you feel better, keep taking linezolid until the prescription is finished. The length of your treatment depends on the type of infection you have. These foods and beverages include alcoholic beverages, especially beer, Chianti, and other red wines; alcohol-free beer; cheeses (especially strong, aged, or processed varieties); sauerkraut; yogurt; raisins; bananas; sour cream; pickled herring; liver (especially chicken liver); dried meats and sausage (including hard salami and pepperoni); canned figs; avocados; soy sauce; turkey; yeast extracts; papaya products (including certain meat tenderizers); fava beans; and broad bean pods. Inquire with your doctor or pharmacist for more details if you believe this medication may be prescribed for other purposes.

Missed dose

Never take two doses at once to make up for missed ones. To continue with your regular dosing schedule, skip the missed dose if it is almost time for the next one. As soon as you remember, take the missed dose.

Overdose

However, if overdose is suspected, seek emergency medical attention. An overdose is unlikely to happen if linezolid is administered by a healthcare professional in a hospital setting. Call your local Poison Control Center or get immediate medical help if you take too much linezolid.

Storage

Children should not have access to any medications. Formulations for linezolid should be kept in a dark, dry place at room temperature (15°C–30°C).

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Side effects

Linezolid side effects were generally mild to moderate in severity. Other negative side effects include tongue discoloration, hypertension, dyspepsia, localized abdominal pain, oral and vaginal moniliasis, and dyspepsia. The most common adverse events in patients treated with Linezolid were diarrhea, headache and nausea.

Interactions

Inform your doctor about all of the medications you take, including vitamins, herbal supplements, prescription and non-prescription drugs.

Contraindications

As a result of taking Linezolid, patients have experienced convulsions. It is advised to seek immediate ophthalmic attention if patients exhibit signs of visual impairment, such as changes in visual acuity, changes in color vision, blurred vision, or visual field defects. If signs or symptoms occur, physicians should consider discontinuation of either one or both agents. Symptoms of discontinuation can be seen if the concurrent serotonergic agent is stopped. These cases included some where seizure history or seizure risk factors were mentioned. Patients who develop recurrent nausea or vomiting, unexplained acidosis or low bicarbonate level while receiving Linezolid should receive immediate medical evaluation. Where administration of Linezolid and concomitant serotonergic agents are clinically appropriate, patients should be closely observed for signs and symptoms of serotonin syndrome such as cognitive dysfunction, hyperpyrexia, hyperreflexia and incoordination.

Is linezolid a MAO inhibitor?

Healthcare professionals and patients may not realize that linezolid has monoamine oxidase inhibitor (MAOI) properties. Linezolid should generally not be given to patients taking serotonergic drugs.

Is linezolid a good antibiotic?

Yes, linezolid (Zyvox) is effective against Methicillin-resistant S. aureus or MRSA. Although vancomycin (Vancocin) still remains as the gold standard for MRSA infections, linezolid (Zyvox) may be an option for certain individuals.

Does linezolid come in IV?

Linezolid injection comes as a solution (liquid) to be infused into a vein. It is usually given as an intravenous infusion over 30 minutes to two hours twice a day (every 12 hours) for 10 to 28 days.

Is linezolid an IV or PO?

Linezolid is available in an intravenous formulation, film-coated tablets and oral suspension. The dose is 600 mg every 12 h and no dose adjustment is needed when switching from the intravenous to oral formulations or when there is moderate renal or hepatic derangement.

What drugs should not be taken with linezolid?

Before using linezolid, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with linezolid, including herbal products (such as ephedra/ma huang), allergy and cold products (including decongestants such as phenylephrine/pseudoephedrine), and stimulants ...

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Testimonials
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Krish Kansara Mar 28, 2013, 10:24:41 AM

+ Cefuroxime 500mg Tablet DESCRIPTION Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. It is used either by injection into a vein or by mouth. PACK STYLE Pack of 6 Tabs/ 10 Tabs/30 ml Bottle

Kushtrim Dec 30, 2011, 12:49:59 PM

Skin and soft tissue infections Pneumonia DOSAGE AND ADMINISTRATION As directed by the physician. The main uses are infections of the skin and pneumonia although it may be used for a variety of other infections including drug resistant tuberculosis. It is used either by injection into a vein or by mouth. For more information, you can mail us at [email protected] Product Details: LIZOSTIN 600 LIZOSTIN 600: Linezolid 600mg.

Kittystone Apr 23, 2015, 7:24:03 PM

This medicine is available only with your doctor's prescription. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. It works by killing bacteria or preventing their growth.

Vanessa Dunkley Jul 31, 2015, 12:21:50 AM

Today we have more than 250 products in Biobrick Pharma with DCGI Approval.We have always focused on improving the health of community by offering safe efficacious and quality Products to cure Peoples on india.

rapscalli Feb 3, 2019, 4:12:30 PM

It is also exported to South East and African countries. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). PACK STYLE Pack of 6 Tabs/ 10 Tabs/30 ml Bottle

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Hari Krishna Ganji Jul 12, 2012, 3:34:04 AM

Linezolid is used to treat serious bacterial infections of skin and soft tissue and pneumonia that are resistant to other antibiotics including methicillin and vancomycin. Linezolid also belongs to a class of drugs known as monoamine oxidase (MAO) inhibitors which block the activity of monoamine oxidases, a family of enzymes in the body. MAO inhibition results in increased concentrations of chemicals that nerves use to communicate (neurotransmitters), including dopamine, norepinephrine, and serotonin, which can increase the chance of certain side effects and food and drug interactions. Gram-positive bacteria and gram-negative bacteria are structurally different, identified by whether they get dyed or not in the Gram stain lab test. Linezolid belongs to a new class of antibiotics known as oxazolidinones.

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