Side effects
Blood clots in your veins or lungs. If you experience any of the following side effects, contact your doctor right away: Modifications in your uterus's endometrium or body. You've noticed a change in your monthly bleeding, such as a change in the timing or amount of bleeding or more clotting. A serious issue might be present if the discharge is bloody. The following is a list of tamoxifen's less frequent but serious side effects. issues with the liver, including jaundice. Your pelvis (the area below your belly button) may be painful or compressed. Stroke can result in fatal medical issues among other serious conditions. Hot flashes are tamoxifen's most common adverse reaction. Vaginal discharge is the subsequent most typical side effect. Slow vision blurring is a symptom of these issues. Sudden chest pain, breathing difficulty, blood in your cough, tenderness or swelling in one or both of your legs, and stroke are all indications of blood clots. Vaginal bleeding or bloody discharge that may be rusty or brown in color are indicators of uterine changes. The signs of liver problems include lack of appetite and yellowing of your skin or whites of your eyes. The following symptoms are indicative of a stroke: sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; and sudden severe headache with no apparent cause. Cataracts or a higher likelihood of requiring cataract surgery. Serious issues like death may result from these. Any time is a possibility for these. These modifications may indicate the beginning of serious issues, such as uterine cancer. This is not a sign of a serious problem. After stopping tamoxifen, you may experience clots for up to two to three months. Even if the bleeding is minimal, you should still call your doctor.
Interactions
With St. John's Wort Take with a full glass of water. Use whether or not you are eating. This herb stimulates CYP3A4 metabolism, which could lower the level of tamoxifen in the blood.
Contraindications
Mention any of the following: cyclophosphamide (Cytoxan, Neosar), letrozole (Femara), medroxyprogesterone (Depo-Provera, Provera, in Prempro), phenobarbital, rifampin (Rifadin, Rimactane), aminoglutethimide (Cytadren), anastrozole (Arimidex), bromo Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take before starting tamoxifen. If a new lump in your breast appears, contact your doctor right away. If you think you became pregnant while taking tamoxifen, stop taking it and contact your doctor right away. Talk to your doctor about how often you should examine your breasts yourself, have a doctor examine your breasts, and have mammograms (x-ray examinations of the breasts). You should continue using birth control even if you don't experience regular menstrual cycles while receiving treatment. Discuss the best forms of birth control with your doctor. Tamoxifen may harm the fetus. tell your doctor if you are breast-feeding. Tell all of your doctors and other healthcare professionals that you are taking tamoxifen. You should not breastfeed during your tamoxifen treatment. You should still be on the lookout for early breast cancer signs because breast cancer can still develop even while you are taking tamoxifen. You should not plan to become pregnant while taking tamoxifen or for 2 months after your treatment. While taking tamoxifen and for two months following treatment, you must use an effective nonhormonal birth control method to avoid getting pregnant. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had high blood levels of cholesterol. tell your doctor if you are pregnant or plan to become pregnant. Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin taking tamoxifen.
In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. However, Tamoxifen is popular with anabolic steroid users to reduce the build up of breast tissue (gynecomastia) caused by the excess aromatization of testosterone to estrogen. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, Hydroxytamoxifen.
“It saves millions of lives.” Balancing Risk and Benefit Tamoxifen is, without question, a powerful drug. The problem lies with selective serotonin reuptake inhibitors, or SSRIs; these drugs can reduce the potency of tamoxifen. tamoxifen is also used for risk reduction for primary cancer and recurrence, and studies don’t always reveal the reasons women choose to take the drug.
Of those, only 32 were open to taking the preventative treatment. Analysts asked 258 healthy women who had an increased risk of breast cancer whether they would take tamoxifen to reduce the risk of the disease. Studies have indicated that tamoxifen could reduce the risk of cancer by a third.
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Despite having pre-period hunger pangs and sore boobs to help warn me, I still can’t clock its exact arrival. The cons ran down one full side of the foolscap paper. I stopped taking my daily dose of Tamoxifen just shy of the two-year mark.
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