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Tamoxifen
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duloxetine tamoxifen interaction

A selective estrogen receptor modulator called tamoxifen is used to treat breast cancer that is estrogen receptor positive, lower the risk of invasive breast cancer after surgery, or lower the risk of breast cancer in high-risk women.

Other names for this medication:
Soltamox, Nolvadex-D

Similar Products:
Yasmin, Bromocriptine, Mircette, Ponstel, Clomid, Progesterone, Aygestin, Prometrium, Clomiphene, Cabergoline, Provera, Norgestrel, Levonorgestrel, Duphaston

Description

Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers and prevent the occurrence of breast cancer in high risk populations. Tamoxifen is used either alone or as an adjuvant in these treatments. Tamoxifen may no longer be the preferred treatment for these types of cancers as patients typically have better survival rates, side effect profiles, and compliance with. On December 30, 1977, the FDA gave tamoxifen its approval.

Dosage

Tamoxifen oral solution 20 mg is administered as 10 mL, or two teaspoons. Divided doses (morning and evening) should be administered for doses higher than 20 mg per day. Tamoxifen 20 mg per day for five years is advised for the treatment of ductal carcinoma in situ (DCIS). Be sure to carefully follow the instructions on your prescription label. Dosage Recommendation For breast cancer patients, a dose of 20–40 mg per day is advised. Tamoxifen 20 mg per day for five years is the recommended dosage for lowering the incidence of breast cancer in high-risk women. Take tamoxifen exactly as prescribed by your doctor. Tamoxifen use longer than five years is not supported by any data. The optimal dose will be chosen by your doctor for you.

Missed dose

Do not take a double dose to make up for a missed one. If, however, it is almost time for the subsequent dose, skip the missed one and carry on with your regular dosing schedule. Take the missed dose as soon as you remember it.

Overdose

Call your neighborhood poison control center or go to the hospital right away if you take too much tamoxifen.

Storage

You shouldn't flush this medication down the toilet, though. The best way to get rid of your medication is instead through a medication take-back program. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Tamoxifen should be kept safely out of children's reach in the original container it was packaged in. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). For information on take-back programs in your neighborhood, speak with your pharmacist or get in touch with the waste/recycling department of your city. Always lock safety caps and put medication in a secure location right away that is up and away and out of young children's sight and reach to prevent poisoning. http://www.upandaway.org To make sure that pets, kids, and other people cannot consume leftover medications, they should be disposed of in a specific manner.

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Side effects

Blood clots in your veins or lungs. If you experience any of the following side effects, contact your doctor right away: Modifications in your uterus's endometrium or body. You've noticed a change in your monthly bleeding, such as a change in the timing or amount of bleeding or more clotting. A serious issue might be present if the discharge is bloody. The following is a list of tamoxifen's less frequent but serious side effects. issues with the liver, including jaundice. Your pelvis (the area below your belly button) may be painful or compressed. Stroke can result in fatal medical issues among other serious conditions. Hot flashes are tamoxifen's most common adverse reaction. Vaginal discharge is the subsequent most typical side effect. Slow vision blurring is a symptom of these issues. Sudden chest pain, breathing difficulty, blood in your cough, tenderness or swelling in one or both of your legs, and stroke are all indications of blood clots. Vaginal bleeding or bloody discharge that may be rusty or brown in color are indicators of uterine changes. The signs of liver problems include lack of appetite and yellowing of your skin or whites of your eyes. The following symptoms are indicative of a stroke: sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; and sudden severe headache with no apparent cause. Cataracts or a higher likelihood of requiring cataract surgery. Serious issues like death may result from these. Any time is a possibility for these. These modifications may indicate the beginning of serious issues, such as uterine cancer. This is not a sign of a serious problem. After stopping tamoxifen, you may experience clots for up to two to three months. Even if the bleeding is minimal, you should still call your doctor.

Interactions

With St. John's Wort Take with a full glass of water. Use whether or not you are eating. This herb stimulates CYP3A4 metabolism, which could lower the level of tamoxifen in the blood.

Contraindications

Mention any of the following: cyclophosphamide (Cytoxan, Neosar), letrozole (Femara), medroxyprogesterone (Depo-Provera, Provera, in Prempro), phenobarbital, rifampin (Rifadin, Rimactane), aminoglutethimide (Cytadren), anastrozole (Arimidex), bromo Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take before starting tamoxifen. If a new lump in your breast appears, contact your doctor right away. If you think you became pregnant while taking tamoxifen, stop taking it and contact your doctor right away. Talk to your doctor about how often you should examine your breasts yourself, have a doctor examine your breasts, and have mammograms (x-ray examinations of the breasts). You should continue using birth control even if you don't experience regular menstrual cycles while receiving treatment. Discuss the best forms of birth control with your doctor. Tamoxifen may harm the fetus. tell your doctor if you are breast-feeding. Tell all of your doctors and other healthcare professionals that you are taking tamoxifen. You should not breastfeed during your tamoxifen treatment. You should still be on the lookout for early breast cancer signs because breast cancer can still develop even while you are taking tamoxifen. You should not plan to become pregnant while taking tamoxifen or for 2 months after your treatment. While taking tamoxifen and for two months following treatment, you must use an effective nonhormonal birth control method to avoid getting pregnant. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had high blood levels of cholesterol. tell your doctor if you are pregnant or plan to become pregnant. Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin taking tamoxifen.

How does tamoxifen metabolized?

Tamoxifen is metabolized via CYP2D6 into endoxifen (4-OH-N-desmethyl-tamoxifen), its primary active metabolite. Multiple investigations have identified genetic variants of CYP2D6 that can affect its activity, which in turn affects the metabolism of tamoxifen.

What does tamoxifen do for bodybuilders?

In breast tissue, tamoxifen acts by competitively inhibiting the estrogen receptor. Because of this inhibition, male body builders use tamoxifen as an adjunct to prevent anabolic steroid-induced gynecomastia, which occurs as a result of peripheral conversion of androgens to estrogens.

What does tamoxifen dissolve in?

Tamoxifen is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of tamoxifen in ethanol and DMF is approximately 20 mg/ml and approximately 2 mg/ml in DMSO.

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Testimonials
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Vijaya Krishna Tummala Feb 1, 2017, 4:23:08 AM

In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. However, Tamoxifen is popular with anabolic steroid users to reduce the build up of breast tissue (gynecomastia) caused by the excess aromatization of testosterone to estrogen. Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, Hydroxytamoxifen.

Klutz Jul 24, 2012, 3:16:23 PM

“It saves millions of lives.” Balancing Risk and Benefit Tamoxifen is, without question, a powerful drug. The problem lies with selective serotonin reuptake inhibitors, or SSRIs; these drugs can reduce the potency of tamoxifen. tamoxifen is also used for risk reduction for primary cancer and recurrence, and studies don’t always reveal the reasons women choose to take the drug.

uncovery Sep 7, 2017, 10:32:26 PM

Of those, only 32 were open to taking the preventative treatment. Analysts asked 258 healthy women who had an increased risk of breast cancer whether they would take tamoxifen to reduce the risk of the disease. Studies have indicated that tamoxifen could reduce the risk of cancer by a third.

Aditya Yadav Apr 23, 2018, 8:04:33 AM

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lorenzo gonzalez Mar 8, 2022, 4:22:55 PM

Despite having pre-period hunger pangs and sore boobs to help warn me, I still can’t clock its exact arrival. The cons ran down one full side of the foolscap paper. I stopped taking my daily dose of Tamoxifen just shy of the two-year mark.

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