Side effects
An increase in cancers was not reported in clinical studies with leflunomide to date. Call your doctor if you have any unusual problems while taking this medication. You or your doctor can report a serious side effect to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment: diarrhea vomiting heartburn headache dizziness weight loss back pain muscle pain or weakness pain, burning, numbness, or tingling in the hands or feet hair loss leg cramps dry skin rash with or without a fever hives blisters or peeling of skin mouth sores itching difficulty breathing new or worsening cough chest pain pale skin Receiving medications which suppress the immune system may increase the risk of developing certain types of cancer. Other side effects of leflunomide are possible. Leflunomide could have unwanted effects. Leflunomide risks should be discussed with your doctor. Any of the following symptoms should be reported to your doctor if they are severe or persistent: diarrhoea, vomiting, heartburn, headache, weight loss, back pain, muscle pain or weakness, pain, burning, numbness, or tingling in the hands or feet, hair loss, leg cramps, dry skin rash with or without a fever, hives, blisters or peeling of the skin, itching difficulty breathing, new or worsening cough, chest pain, pale skin
Interactions
Take with or without food. The absorption is unaffected by food.
Contraindications
Inquire with your doctor if drinking alcohol is safe for you to do while taking leflunomide. Without consulting your doctor, avoid getting any vaccinations. Leflunomide should not be taken if you have any of the following conditions: an allergy to leflunomide or any of its ingredients; are pregnant; or have liver disease. Leflunomide may exacerbate an existing tuberculosis (TB) infection and, if you don't already have any, may make your condition worse. Before you start taking leflunomide, your doctor will administer antibiotics to treat the infection if you do have TB. If you experience any of the following symptoms during your treatment with leflunomide, call your doctor: fever; sore throat; cough; flu-like symptoms; area of warm, red, swollen, or painful skin; painful, difficult, or frequent urination; or other signs of infection. Low blood cell counts and anemia may result from leflunomide. Rare cases of severe skin reactions have been reported. There have been reports of serious side effects. Leflunomide treatment has been associated with severe liver damage, including fatal liver failure. You run a higher risk of getting an infection if you take leflunomide. If you develop a skin rash while undergoing treatment, let your doctor know. Inform your doctor right away if you notice any symptoms of liver disease, such as: extreme fatigue, stomach pain, or yellowing of the skin or whites of the eyes (jaundice). Leflunomide may also raise blood pressure. Before starting treatment and on a regular basis going forward, have your blood pressure checked. If you have an infection, your leflunomide treatment may need to be stopped.
In either case the A771726 plasma concentration is then measured for the first time. Patients with a history of tuberculosis should be carefully monitored because of the possibility of reactivation of the infection. hepatotoxicity, haematotoxicity or allergic reactions, see below), even if the treatment with leflunomide has been stopped. In the event that severe, uncontrolled infections occur, it may be necessary to interrupt leflunomide treatment and administer a washout procedure as described below. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
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First approved for use in the United States in 1998, Arava has been tied to a wide range of side effects. Visit our attorney directory, look for your geographic location and find the best lawyer for your situation. If you or someone you love has suffered injury after being prescribed Arava, GetLegal has the tools and resources to help you find skilled legal representation to protect your rights. Arava, the trade name for Leflunomide, is a prescription drug manufactured and marketed by Sanofi Aventi for the treatment of rheumatoid arthritis and psoriatic arthritis. Among the most common adverse health consequences tied to the product are: Indigestion, appetite loss, nausea, vomiting, diarrhea and abdominal pain Abnormal liver functions High blood pressure Respiratory infections, bronchitis, cough, and pneumonia Weight loss Headaches, dizziness and general fatigue The use of Arava has also been linked to constipation, loss of taste sensation, hives, cirrhosis of the liver and liver failure.
LOOKING FOR ALTERNATIVE SUBSITUTE OR GENERIC BENFOTIAMINE CALCITEROLIN CISSUS QUADRANGULARIS THYROXINE CITICOLINE PIRACETAM DONEPAZIL DOSULEPIN LEVOCARNITINE LEFLUNOMIDE MIRTAZAPINE PREGABALIN NORTYPTLINE QUTIAPINE ROPINIROLE RISPERIDONE ALPHA KETANALOGUE CACLIUM ACETATE SAVELINE SODIUM CARBONATE ACETYLECYSTINE TAURIN ALFUZOSIN DUTASTERIDE BETHNICHOL BICALUTAMIDE FEBUOXATE FLAVOXATE PRAZOSIN SILODOSIN SOLIFENACIN TAMSULOSIN FINESTERIDE TORSEMIDE SPIRONOLACTONE CRANBERRY EXTRACT HIBBISCUS D MANNOSE AMIODARONE ATORVASTATIN VITAMIN D3 CLOPIDOGREL CARVEDILOL CILINIDIPINE TELMISARTAN CLONIDINE DIGOXIN DILTIAZEM CHLORTHALIDONE FENOFIBRON HYDROCHLORTHAIZIDE IVABRADINE INDAPAMIDE LABETALOL LOSATAN ATENOLOL NICORANDIL METAPROLOL AMLODIPINE RAMIPRIL METOLAZONE METALOZONE NEBIVOLOL OLMISARTAN PRASUGREL ROSUVASTATIN ACEBROPHYLLIN BACLOFEN CLONDAMYCIIN ESOMEPRAZOLE ILAPRAZOLE ITOPRIDE LEVOSULPRIDE LACTULOSE MEMENTINE SODIUM PICOSULPHATE PROCHLOROPERAZINE POTASSIUM CHLORIDE.
Consider therapy modification Mercaptopurine: May enhance the adverse/toxic effect of Vaccines (Live). Tisagenlecleucel may diminish the therapeutic effect of Vaccines (Live). Management: Low-dose methotrexate (0.4 mg/kg/week or less) is not considered sufficiently immunosuppressive to create vaccine safety concerns. Avoid combination Guselkumab: May enhance the adverse/toxic effect of Vaccines (Live).
If you experience any of these signs, make sure to contact your doctor immediately. • Do not take Leflunomide: • If you are allergic to Leflunomide or any of the ingredients in this medicine. Make sure to tell your doctor about any previous liver problems that you have. If this happens, make sure to tell your doctor.