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pantoprazole side effect

If taken empty-handed, pantoprazole might work more effectively. Pantoprazole reduces stomach acid, stops heartburn, and heals ulcers.

Other names for this medication:
Protonix, Tecta, Somac Control

Similar Products:
Loperamide, Domperidone, Mebeverine, Aciphex, Imodium, Sulfasalazine, Famotidine, Mesalamine, Colospa, Reglan, Motilium, Prilosec


You should employ a confirmatory technique. Note on abnormalities in laboratory tests The association of PPIs with an increased risk of cardiovascular events in patients with unstable coronary syndromes is thought to be due to the accumulation of the nitric oxide synthase inhibitor asymmetric dimethylarginie (ADMA) that results from DDAH inhibition. Their use is currently very common in North America due to their good safety profile and the fact that several PPIs are available over the counter without a prescription. Serum gastrin, a peptide hormone that promotes gastric acid secretion, rises during treatment with antisecretory drugs like pantoprazole in response to the decreased acid secretion brought on by proton pump inhibition. Effects Generally It can be used safely in various high-risk patient populations, including the elderly and those with renal failure or moderate hepatic dysfunction. However, long-term use of PPIs, such as pantoprazole, has been linked to potential negative effects, such as increased susceptibility to bacterial infections (including gastrointestinal C. difficile), reduced absorption of micronutrients like iron and B12, and an increased risk of developing hypomagnesemia and hypocalcemia, which may cause osteoporosis and bone fractures later in life. An enzyme required for cardiovascular health, dimethylarginine dimethylaminohydrolase (DDAH), has been shown to be inhibited by PPIs like pantoprazole. A long-lasting inhibition of gastric acid secretion results from taking pantoprazole. Pantoprazole has been shown to reduce acid reflux-related symptoms, heal inflammation of the esophagus, and improve patient quality of life more effectively than histamine-2 receptor antagonists (H2 blockers). According to published research, proton pump inhibitors should be stopped 14 days prior to chromogranin A (CgA) measurements. Reports have been made of false-positive results in urine screening tests for tetrahydrocannabinol (THC) in patients receiving the majority of proton pump inhibitors, including pantoprazole. Research into neuroendocrine tumors could be hampered by the elevated gastrin level. This drug acts to decrease gastric acid secretion, which reduces stomach acidity. This drug has an excellent safety profile and a low incidence of drug interactions. After taking a proton pump inhibitor, chromogranin A levels may become erroneously elevated. This allows them to return to the normal reference range.


One daily oral dose of 40 mg. A 12-month pantoprazole course has only been studied in controlled studies. It has not been studied to administer doses daily greater than 240 mg divided equally over a 15-minute infusion or for longer than 6 days. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete duodenal ulcer healing in up to 87% and 94% of patients after 4 weeks and 8 weeks respectively. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete gastric ulcer healing in up to 87% and 97% of patients after 4 weeks and 8 weeks respectively. comprehensive instructions on Pantoprazole dosage In 82% of patients, Helicobacter Pylori eradication was successful. As soon as the patient is able to resume oral therapy, intravenous therapy should be stopped. 40 mg orally once daily for the maintenance of erosive esophagitis healing. Oral: 40 mg orally once a day, for short-term administration (up to 8 weeks); however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Oral: 40 mg twice daily, to a maximum of 240 mg per day. Parenteral: 40 mg once a day for 7 to 10 days, administered via intravenous infusion over a period of 15 minutes. Parenteral: 80 mg every 12 hours, administered by 15-minute infusion. Beyond 16 weeks of therapy, safety and effectiveness have not been proven. Some patients have received treatment with pantoprazole for more than 2 years. Study (n=20) - Peptic Ulcer Rebleeding Prophylaxis after Hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI. Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily as a bolus infusion over a 15-minute period, up to a daily dose maximum of 240 mg, divided into three equal doses. Study (n=242) - Triple therapy: 40 mg orally twice daily for 7 days, typically in conjunction with clarithromycin and either amoxicillin or metronidazole to eradicate Helicobacter pylori, then 40 mg orally once daily for the remaining 28 days. Study (n=54): 40 mg taken once daily; dose was increased by 40 mg every 12 weeks for a total of 28 weeks, up to a maximum of 120 mg. The QUADRATE Study (n=405) - Quadruple therapy: 40 mg orally twice daily for 7 days, concomitantly with bismuth subcitrate and tetracycline, both four times daily, and metronidazole 200 mg three times daily and 400 mg at bedtime. Treatment for erosive esophagitis involves taking 40 mg once daily by mouth for a maximum of 8 weeks. For patients who have not recovered after the first course of treatment, an additional 8 weeks may be considered. Triple therapy has resulted in eradication rates of greater than 95%. Common Adult Dose for Duodenal Ulcer: The typical adult dosage for erosive esophagitis is: Common Adult Dose for Gastritis: For gastroesophageal reflux disease, the typical adult dosage is: Usual Adult Dose for Helicobacter Pylori Infection: Common Adult Dose for Peptic Ulcer: Usual Adult Dose for Stress Ulcer Prophylaxis: Zollinger-Ellison syndrome standard adult dosage:

Missed dose

Do not take a double dose to make up for a missed dose. Skip the missed dose and carry on with your regular dosing schedule, though, if it is almost time for your next dose. Take the missed dose as soon as you remember it.


Call your doctor right away if you take too much pantoprazole sodium.


This medication should not, however, be flushed down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

For medical advice about side effects, contact your doctor. Pantoprazole may have harmful side effects, such as: Vitamin B-12 deficiency Serious allergic reactions; Long-term use may weaken the stomach lining. Talk with your doctor or pharmacist if you have any questions about side effects. Any side effects that bother you or do not go away should be brought up with your doctor. If you experience any of the following symptoms while taking pantoprazole: rash, face swelling, throat tightness, or difficulty breathing, let your doctor know. In such cases, the medication may be discontinued. The most typical side effects of pantoprazole in adults are: Headache Diarrhea Nausea Stomach pain Vomiting Gas Dizziness Pain in your joints The most typical side effects of pantoprazole in children are: Upper respiratory infection Headache Fever Diarrhea Vomiting Rash Stomach pain Long-term use of multiple daily doses of proton pump inhibitor medications may increase the risk of hip, wrist, or spine fractures. The side effects of pantoprazole are not limited to those listed here. You may report side effects to the FDA at 1-800-FDA-1088.


Tell your doctor right away if you take any of the following medications, in particular: Warfarin (Coumadin, Athrombin-K, Jantoven, Panwarfin), Ketoconazole (Nizoral), Atazanavir (Reyataz), Nelfinavir (Viracept), Iron supplements, Ampicillin antibiotics. If you are unsure whether any of your medications are of the type mentioned above, ask your doctor. Pantoprazole may affect how other medicines work, and other medicines may affect how pantoprazole works. In addition to prescription and over-the-counter medications, vitamins, and herbal supplements, be sure to let your doctor know about everything you take.


Ask your pharmacist for a list of the ingredients. tell your doctor if you are taking rilpivirine (Edurant, in Cabenuva, Complera, Juluca, Odefsey). Anticoagulants (blood thinners) like warfarin (Jantoven), atazanavir (Reyataz, in Evotaz), dasatinib (Sprycel), digoxin (Lanoxin), diuretics ('water pills'), erlotinib (Tarceva), iron supplements, itraconazole (Sporanox, Tolsura), ketoconazole, methotrexate (Trexall, X Before taking pantoprazole, tell your doctor and pharmacist if you are allergic to pantoprazole, dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, in Zegerid), rabeprazole (AcipHex), any other medications, or any of the ingredients in pantoprazole tablets or granules. Keep in mind that your doctor may have advised you to take this medication for a shorter amount of time. If you become pregnant while taking pantoprazole, call your doctor. talk to your doctor about the risks and benefits of taking pantoprazole if you are 70 years of age or older. Tell your doctor if you have or have ever had low levels of magnesium, calcium, or potassium in your blood; hypoparathyroidism (condition in which the body does not produce enough parathyroid hormone [PTH]; a natural substance needed to control the amount of calcium in the blood]); low levels of vitamin B12 in your body; or osteoporosis (condition in which the bones become brittle). Your doctor will probably tell you not to take pantoprazole if you are taking this medication. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

Will it affect my fertility?

There's no evidence to suggest that taking pantoprazole will reduce fertility in either men or women. However, speak to a pharmacist or your doctor if you're trying to get pregnant as they may want to review your treatment.

What is Pantoprazole used for?

It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) – GORD is when you keep getting acid reflux. It's also taken to prevent and treat stomach ulcers. Sometimes, pantoprazole is taken for a rare condition caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.

How long can I take pantoprazole?

You should only take pantoprazole for up to 8 weeks if you are buying it without a prescription or a physician evaluation of your symptoms. This is because certain stomach symptoms that persist for more than 4 to 8 weeks should be investigated by a doctor, as they may be a sign of something more serious, such as cancer. Pantoprazole is very good at relieving and hiding serious stomach symptoms, which may make you think you don’t need to see a physician. Long-term use of pantoprazole has also been associated with vitamin B12 deficiency; low magnesium, calcium, iron, or vitamin C levels; and an increased risk of fractures of the hip, wrist, or spine. Elderly, the malnourished, or those on dialysis are more at risk.

Can I drink alcohol with it?

Alcohol does not affect the way pantoprazole works. However, it's best not to drink too much alcohol because drinking alcohol makes your stomach produce more acid than normal. This can irritate your stomach lining and make your symptoms worse.

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BuV8 Mar 13, 2013, 2:33:10 AM

conducted a study to evaluate the efficacy of pantoprazole in reducing gastric acid secretion among patients with Zollinger-Ellison syndrome in comparison to other proton-pump inhibitors (including omeprazole). Results indicated that, of all proton-pump inhibitor regimens compared, pantoprazole (40 mg/day) had the highest probability (36%) of facilitating the best duodenal ulcer healing rate after 4 weeks of treatment. Withdrawal symptoms from pantoprazole and omeprazole will likely be most noticeable in long-term, high-dose users who refrain from using substances to control stomach acid production after proton-pump inhibitor cessation. Since omeprazole is formally approved by the FDA to treat H. Pylori (with antibiotics) and pantoprazole is not, some could argue that omeprazole is a superior treatment “choice” over pantoprazole for this condition. Included below is a chart that highlights general characteristics of pantoprazole (Protonix) and omeprazole (Prilosec).

Ranson Tham May 19, 2022, 10:35:02 AM

This medication is used to treat stomach problems as well as esophagus ailments. It also resolves the acid problems and belongs to a class of drugs which is known as proton pump inhibitors. Here are some of the precaution that one needs to follow while consuming this medication Keep it away from the reach of children.

theDoctor Aug 31, 2014, 7:28:14 PM

The recommended dose of PANTOTAJ-DSRcapsules is one capsule daily before breakfast. Oral Ketoconazole and Oral Erythromycin • Separate in vivo pharmacokinetic/pharmacodynamic interaction studies with oral ketoconazole or oral erythromycin in healthy subjects confirmed a marked inhibition of domperidone’s CYP3A4-mediated first pass metabolism by these drugs. No dose adjustment of clopidogrel is necessary when administered with an approved dose of pantoprazole. Safety of pantoprazole in the treatment of erosive esophagitis (EE) associated with GERD was evaluated in paediatric patients aged 1 year through 16 years in three clinical trials.

Nallamilli reddy May 17, 2017, 11:44:18 PM

It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux).

Alex Deva Jun 20, 2020, 1:46:58 AM

Dopamine inhibits gastrointestinal motility, reduces gastric and esophageal sphincter tone and inhibits gastroduodenal coordination. • Binds to an enzyme in the presence of acidic gastric pH, preventing the final transport of hydrogen ions into the gastric lumen. The proportion of the medicine excreted unchanged is small (10% of faecal excretion and approximately 1% of urinary excretion). Domperidone increases lower esophageal • sphincter tone and enhances upper GI motility, thereby preventing reflux of gastric contents into esophagus.

Ioannes Apr 15, 2014, 11:45:15 PM

Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Pantoprazole Sodium Sesquihydrate 40 mg Domperidone 10 mg Click on to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

garrettg84 Nov 2, 2016, 11:04:38 PM

Risk factors include intake of oil-rich foods, smoking of tobacco products as well as intake of caffeine and / or alcohol. Ranitidine is a widely used drug, mainly taken to reduce the build-up of acids. Commonly experienced side effects include difficulties to pass stools (i.e., constipation), migraine / severe spells of headache, indigestion, abdominal problems such as nausea, vomiting and pain in the abdomen. Hence, taking these two meds as a combination may present limited benefits.

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