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Lamotrigine
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Information on lamotrigine that has been reviewed by a doctor, including a description, dosage information, and administration guidelines.

Other names for this medication:
Lamictal

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Description

Lamotrigine works similarly to phenytoin and carbamazepine, though chemically unrelated, by blocking voltage-sensitive sodium channels, stabilizing neuronal membranes, and controlling the release of presynaptic excitatory neurotransmitters. Lamotrigine is known to inhibit Cav2.3 (R-type) calcium currents, which may also contribute to its anticonvulsant effects, according to an in vivo study. In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also has a weak affinity for the Adenosine A1/A2 receptor, the 1/2/adrenergic receptor, the dopamine D1/D2 receptor, the GABA A/B receptor, the histamine H1 receptor, the -opioid receptor (KOR), the mACh receptor, and the serotonin 5-HT2 receptor (IC50 > 100 M). Lamotrigine displays binding properties to several different receptors. Lamotrigine probably inhibits sodium currents by selectively attaching to the inactive sodium channel and preventing the release of glutamate, an excitatory amino acid. Studies on lamotrigine have revealed that it binds to sodium channels in a way that is similar to local anesthetics, which may help to explain why lamotrigine has been shown to be clinically effective in treating some neuropathic pain conditions. Lamotrigine may exert cellular activities that contribute to its efficacy in a variety of conditions, but its precise mechanism of action is not fully understood. The mechanism of action of lamotrigine in reducing anticonvulsant activity is likely the same in managing bipolar disorder. At sigma opioid receptors, weak inhibitory effects were seen.

Dosage

Always double-check your refills to make sure you're getting the right kind of tablet—the right size, color, and shape. Ask your doctor or pharmacist if you do not understand these instructions. Use only the medication your doctor has prescribed in the dosage and form. Complete instructions on Lamotrigine dosage Even if you feel fine, don't stop taking lamotrigine abruptly. Lamotrigine with immediate and extended releases can be used for various conditions. Read all medication guides or instruction sheets and adhere to all instructions on your prescription label. Pay attention to your doctor's advice when it comes to tapering your dose. Follow your doctor's advice carefully regarding the timing and dosage of your medication if you switch from another seizure medication to lamotrigine. Wear or carry medical identification to let people know you take seizure medication in an emergency. You might receive inaccurate results from a urine drug test if lamotrigine is taken into consideration. The orally disintegrating or dispersible tablet's instructions for use should be read and carefully followed. Stopping abruptly may increase seizure frequency. Store at room temperature away from light and moisture. Don't break, chew, or crush the tablet; just swallow it whole. Initiating treatment with too much lamotrigine may increase your risk of developing a severe, potentially fatal skin rash. Mention your use of lamotrigine to the lab staff. Follow the medication's directions to the letter. To ensure you are receiving the proper dosage, your doctor may need to perform frequent blood tests on you. Sometimes, your doctor might adjust your medication.

Missed dose

Never combine two doses into one. Prevent completely running out of medicine by having your prescription filled. If it is almost time for your next dose, skip the missed dose and take the medication as soon as you remember.

Overdose

Call your neighborhood Poison Control Center right away if you take too much lamotrigine, or go to the nearest emergency room.

Storage

You should not, however, dispose of this medication in the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication tightly closed in the original container and out of the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature, away from sources of extreme heat and moisture (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. Always lock safety caps and immediately store medications up and away and out of young children's sight and reach. http://www.upandaway.org Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot ingest them.

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Side effects

If you experience any of the following: Call your doctor for medical advice about side effects. Common side effects may include: If you experience any of the warning signs of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling), seek emergency medical attention. You might not be able to take lamotrigine again in the future if you have to stop taking it due to a severe skin rash. Effects of lamotrigine (in more detail) Inform your doctor of any new or escalating symptoms, including any changes in mood or behavior, depression, anxiety, or feelings of hostility, restlessness, hyperactivity (mentally or physically), or thoughts of suicide or self-harm. There may be additional side effects; this is not a comprehensive list. You can contact the FDA to report side effects at 1-800-FDA-1088. fast, slow, or pounding heartbeats or fluttering in your chest; chest pain, shortness of breath; fever, swollen glands, weakness, severe muscle pain; any skin rash, especially with blistering or peeling; painful sores in your mouth or around your eyes; headache, neck stiffness, increased sensitivity to light, nausea, vomiting, confusion, drowsiness; jaundice (yellowing of the skin or eyes); or pale skin, cold hands and feet, easy bruising, unusual bleeding. Back pain, insomnia, drowsiness, fatigue, nausea, vomiting, blurred or double vision, tremor, loss of coordination, headache, dizziness, blurred or double vision, blurred vision, double vision, blurred vision, dry mouth, nausea, vomiting, stomach pain, diarrhea, fever, sore throat, runny nose, and back pain.

Interactions

Lamotrigine drug interactions (more information) Lamotrigine may interact with other medications, including over-the-counter, prescription, and herbal remedies. Other medications you take may experience increased side effects or lose some of their effectiveness if certain medications have an impact on the blood levels of those medications. Utilizing certain medications concurrently is occasionally not advised. Inform your doctor about all of your current medications as well as any new or discontinued ones.

Contraindications

One in 500 adults and children aged 5 years and older who were treated with anticonvulsants like lamotrigine in clinical studies for a variety of conditions developed suicidal thoughts while on the medication. Ask your doctor or pharmacist or check the Medication Guide for a list of the ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. In case you are unable to call for help on your own, make sure your family or caregiver is aware of any symptoms that could be serious. Mention the drugs listed in the IMPORTANT WARNING section as well as atazanavir and ritonavir (Reyataz with Norvir), disopyramide (Norpace), lopinavir and ritonavir (Kaletra), methotrexate (Rasuvo, Trexall, Trexup), other seizure medications like carbamazepine (Epitol, Tegretol, others), Inform your doctor and pharmacist if you have any allergies prior to taking lamotrigine, whether they be to that drug, any other medications, or any of the ingredients in the specific brand of lamotrigine tablets you'll be taking. You should be aware that while you are taking lamotrigine for the treatment of epilepsy, mental illness, or other conditions, your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so). Tell your doctor if you have any bleeding between expected menstrual cycles if you are taking a female hormonal medication, if you have or have ever had an autoimmune disease (condition in which the body attacks its own organs, causing swelling and loss of function), such as lupus (condition in which the body attacks many different organs, causing a variety of symptoms), a blood disorder, depression, mood issues, or suicidal thoughts or actions, heart failure, or if you have ever had Call your doctor right away and let him or her know if you become pregnant while taking lamotrigine. If you breast-feed during your treatment with lamotrigine, your baby may receive some lamotrigine in breast milk. One week after they began taking the medication, some of these people started exhibiting suicidal thoughts and actions. Before beginning or stopping any of these medications while taking lamotrigine, consult your doctor. If you take an anticonvulsant medication like lamotrigine, there is a chance that your mental state will change. However, there is also a chance that your condition will worsen if you don't get treatment. Watch your baby closely for unusual sleepiness, interrupted breathing, or poor sucking. you should know that this medication may make you drowsy or dizzy. Whether the risks of using an anticonvulsant medication outweigh the risks of not using it will be decided by you and your doctor. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; withdrawing from friends and family; preoccupation with death and dying; giving away prized possessions; or any other unusual changes in behavior or mood. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you are using female hormonal medications such as hormonal contraceptives (birth control pills, patches, rings, injections, implants, or intrauterine devices), or hormone replacement therapy (HRT).

What are the side effects of lamotrigine?

Lamotrigine may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, or drowsiness. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If these reactions are especially bothersome, check with your doctor.

How does lamotrigine work?

For epilepsy – brain cells normally "talk" to each other using electrical signals and chemicals. Seizures can happen when the brain cells are not working properly or working faster than normal. Lamotrigine slows down these electrical signals to stop seizures. For bipolar disorder – we do not really know how lamotrigine prevents low mood in people. It might work in a similar way to epilepsy. Sometimes it's called a mood stabiliser, as it reduces mood swings.

Are there similar medicines?

There are lots of medicines that can be used for epilepsy and bipolar disorder, but they work in different ways. They might have different side effects, or be taken more or less often. If you have epilepsy, the choice will depend on the type of seizures that you have. Your doctor will discuss the best medicine for you. If you have low mood with bipolar disorder, other medicines your doctor might use include lithium or quetiapine.

How can I come off lamotrigine?

If you're taking lamotrigine for epilepsy, stopping it suddenly can cause seizures. Coming off lamotrigine should be done very slowly and might take a few months. If you're taking lamotrigine for bipolar disorder, it's usually safe to stop taking it without having to reduce your dose first. If you get a serious side effect, such as a severe skin rash, your doctor may tell you to stop taking lamotrigine straight away, even if you have epilepsy. Important Do not stop taking lamotrigine without talking to your doctor first.

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Testimonials
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xManh Oct 19, 2018, 9:46:10 AM

Before you start using the medication, talk to your doctor about your medical condition and about the existing medications that you are taking especially the Over the counter drugs. For patients suffering from epilepsy, they can order Lamotrigine and other Medications for the best health through SafeCanadaPharmacy.com. Likewise, it is also used for patients suffering from mood disorders or bipolar disorders It belongs to the family of drugs called as anti-epileptic or AED.

CUTIEMONSTA Feb 19, 2013, 5:31:43 PM

First a patient may experience flu-like symptoms of fever, cough or sore throat, then a rash or skin blistering will follow. The risk of rash increases with higher starting doses, higher escalating doses and use of lamotrigine in combination with valproate. Some people who take lamotrigine may experience adverse reactions or side effects.

user3454103 Nov 6, 2012, 2:13:50 PM

In women taking a hormonal contraceptive that includes one week of inactive treatment ("pill-free week"), serum lamotrigine level monitoring should be conducted during week 3 of active treatment, i.e. Therefore, consideration should be given to using contraception without a pill-free week, as first-line therapy (for example, continuous hormonal contraceptives or non-hormonal methods; see sections 4.4 and 4.5). Dose increases should not exceed this rate, unless the clinical response supports larger increases. It is recommended that Lamotrigine tablet not be restarted in patients who have discontinued due to rash associated with prior treatment with lamotrigine unless the potential benefit clearly outweighs the risk. It is recommended that from the time that the hormonal contraceptive is started, the lamotrigine dose is increased by 50 to 100 mg/day every week, according to the individual clinical response.

Forres May 24, 2022, 8:17:42 AM

Prescribers should assess the need for escalation to maintenance dose when restarting Lamotrigine in patients who have discontinued lamotrigine for any reason, since the risk of serious rash is associated with high initial doses and exceeding the recommended dose escalation for lamotrigine (see section 4.4). Initial, escalation and maintenance doses should generally be reduced by approximately 50% in patients with moderate (Child-Pugh grade B) and 75% in severe (Child-Pugh grade C) hepatic impairment. The transition regimen involves escalating the dose of lamotrigine to a maintenance stabilisation dose over six weeks (Table 3) after which other psychotropic medicinal products and/or AEDs can be withdrawn, if clinically indicated (Table 4). No dosage adjustment from the recommended schedule is required.

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