Side effects
Rarely will this medication cause a very serious allergic reaction. Although sitagliptin by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if this drug is prescribed with other diabetes medications. To find out what to do if you miss a meal, speak to your doctor or pharmacist. If you experience any extremely serious side effects, such as signs of pancreatitis (such as nausea/vomiting that won't stop, loss of appetite, or excruciating stomach/abdominal/back pain), seek medical attention right away. However, if you experience any of the following signs of a serious allergic reaction, seek medical attention right away: rash, itching or swelling (especially of the face, tongue, or throat), extreme dizziness, or difficulty breathing. Inform your doctor right away if any of these symptoms appear. If you are lacking these dependable sources of glucose, quickly raise your blood sugar levels by consuming fruit juice or regular soda, or by eating a quick source of sugar like table sugar, honey, or candy. Contact your doctor or pharmacist if you experience any other effects that aren't covered above. For medical advice about side effects in Canada, call your doctor. For medical advice about side effects in the US, call your doctor. It is a good practice to always have glucose gel or tablets on hand to treat low blood sugar. If you consume a lot of alcohol, engage in unusually strenuous exercise, or don't get enough calories from food, your risk of developing low blood sugar increases. Many people using this medication do not have serious side effects. Keep in mind that your doctor has prescribed this medication because they believe it will benefit you more than it will harm you. Hyperglycemia, also known as high blood sugar, causes symptoms such as increased urination, thirst, confusion, drowsiness, flushing, rapid breathing, and a fruity breath odor. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. If the dosage of your other diabetes medication(s) needs to be lowered, discuss this with your physician or pharmacist. As soon as possible, inform your doctor of the reaction. Tell your doctor right away of any serious side effects, including: signs of kidney problems (such as change in the amount of urine), joint pain, unusual skin blisters, signs of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain). This is not a complete list of possible side effects. Eat meals on a regular schedule and avoid skipping them to help prevent low blood sugar. You can contact the FDA to report side effects at 1-800-FDA-1088 or online at www.fda.gov/medwatch. Health Canada can be contacted at 1-866-234-2345 if you wish to report side effects. The diabetes medication(s) you're taking may need to be changed by your doctor.
Interactions
Drug interactions for Januvia (more information) If you take other medications at the same time as Januvia, it might not work as well. The management of blood sugar can also be impacted by many other medications. Not all possible interactions are covered here. Prescription, over-the-counter, vitamin, and herbal medications as well as other drugs may have an impact on sitagliptin. Tell your doctor about all medicines you start or stop using. Tell your doctor about all of the medications you are taking now as well as any new or discontinued ones. This includes vitamins, herbal products, prescription and over-the-counter medications. If you also use insulin, you might be more prone to low blood sugar.
Contraindications
Do not stop taking your medication. If you have a reaction to any of the ingredients in Januvia, avoid taking the medication. Contact your doctor right away if you experience severe or persistent joint pain. Swelling of the face, lips, tongue, and throat that may make it difficult to breathe or swallow are signs of a serious allergic reaction to Januvia. Tell your doctor if you have or have ever had pancreatitis, an inflammation of the pancreas. Tell your doctor if you have kidney problems or any other medical conditions. If your medication is thought to be the probable cause of excruciating joint pain, your doctor will decide whether to stop taking it.
Insulin is a hormone that is necessary to carry glucose from the blood into the cells of the body, where it can be used. This prescription medication contains the active ingredient sitagliptin and belongs to a class of drugs called dipeptidyl peptidase-4 inhibitors. There are several alternative medications for treating type 2 diabetes. Metformin is sometimes prescribed in combination with other diabetes medications or insulin 2.
• You should avoid drinking alcohol while using this medicine because Kaletra liquid already contains alcohol. You should take care of unprotected sex or sharing razors and toothbrushes. Minimum age limit to take Kaletre is 14 days. Ritonavir and Lopniavirboth are antiviral medications that prevent human immunodeficiency virus (HIV) cells from multiplying in human body. Follow your medical expert's directions about any restrictions on beverages, food or activity.
These findings were based on examination of a small number of pancreatic tissue specimens taken from patients after they died from unspecified causes. They are used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. "At present, the GLP-1 class of drugs is heavily promoted (and prescribed) as having purported advantages that outweigh its risks. Writing in an accompanying commentary, Belinda Gier, PhD, and Peter Butler, MD, from the Larry L. Hillblom Islet Research Center, University of California, Los Angeles, agree, calling the issue of pancreatic cancer "the real crux of the controversy with regard to the safety of GLP-1–based treatment." • And our last report about Victoza was in November 2012: "The Drug-Induced Pancreatitis Safety Problem That Hangs Around Victoza Gets Another Look".
The use of such products, irrespective of indication, is prohibited and will require a TUE. This is now listed as permitted and a TUE is not required. {openx:269} Diabetic athletes should note that the (World Antidoping Agency) WADA have recently clarified the status of Sitagliptin (Januvia). An athlete wishing to become a bone marrow donor, for which the procedure involves the administration of Filgrastim (Neupogen), Pegfilgrastim (Neulasta), Lenograstim (Granocyte), Molgramsatim (Leucomax) or other granulocyte colony stimulating factor will be required to apply for a standard Therapeutic Use Exemption (TUE).
Other DPP-4 inhibitors such as omarigliptin (Marizev), sitagliptin (Januvia), vildagliptin (Galvus), and saxagliptin (Onglyza) were also associated with a higher risk of fractures compared to placebo. This review included 117 studies with 221,364 patients that had T2D. Voglibose (Voglib), an α-glucosidase inhibitor, significantly decreased the risk of fracture compared to placebo by 97%.
In summary, this recent study found that the DPP-4 inhibitor class of drugs is not associated with IBD; however, DPP-4 inhibitor diabetes drugs, such as Januvia and Onglyza, increase the risk of Crohn's disease (CD). Now, about a year later, the medical journal Annals of Pharmacotherapy has published an article, "Dipeptidyl Peptidase-4 Inhibitors and Inflammatory Bowel Disease Risk: A Meta-analysis", which concludes that DPP-4 inhibitors do not appear to increase the risk of developing IBD -- but goes on to point out that these drugs, such as Januvia and Onglyza, increase the risk of Crohn's disease (CD). In the primary random-effects analysis, DPP-4 inhibitor exposure resulted in a nonsignificant increase in the risk of [inflammatory bowel disease (IBD)] (RR = 1.52; 95% CI = 0.72 to 3.24; I2 = 54.2%).... DPP-4 inhibitor use significantly increased the risk of [Crohn's disease (CD)] (RR = 2.47; 95% CI = 1.36 to 4.48)....