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Isosorbide
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isosorbide dinitrate brand

Isosorbide can only be used to prevent angina; it cannot be used to stop an angina attack once it has started. Chest pain in patients with coronary artery disease is treated with isosorbide extended-release (long-acting) tablets and extended-release capsules. For the treatment of angina (chest pain) in those with coronary artery disease (narrowing of the blood vessels that supply blood to the heart), isosorbide immediate-release tablets are used. Isosorbide belongs to the vasodilator drug class. By allowing the blood vessels to relax, it allows the heart to beat more easily and use less oxygen.

Other names for this medication:
Bidil, Dilatrate, Isordil

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Description

The use of isosorbide to temporarily lower intraocular pressure and stop an acute glaucoma attack was previously recommended, but this use is not currently accepted. For additional isosorbide indications, see the drug entries and.

Dosage

Continue to take isosorbide even if you feel well. Do not stop taking isosorbide without talking to your doctor. Do not take more or less of it or take it more often than prescribed by your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. At any point during your treatment, call your doctor if your chest pain attacks happen more frequently, last longer, or get worse. To be swallowed whole, isosorbide is available as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule. Coronary artery disease cannot be cured by isosorbide, but it can control chest pain. After using isosorbide for a while or taking multiple doses, it might not work as well. To treat heart failure, isosorbide tablets are also taken in combination with other drugs. Do not crush, chew, or divide the tablets or capsules for extended release; instead, swallow them whole. Administer isosorbide exactly as prescribed. Talk to your doctor about the possible risks of using this medication for your condition. The extended-release capsule is typically taken once daily. Typically, one daily morning dose of the extended-release tablet is required. The tablet is typically taken twice or three times a day. Ask your doctor or pharmacist for more details if you're interested in using this medication for a different purpose. Keep eating normally unless your doctor instructs you otherwise. Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide.

Missed dose

To make up for a missed dose, do not take a second one. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. As soon as you remember, take the missed dose.

Overdose

If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. To report an overdose, dial 1-800-222-1222 for the poison control hotline. Additionally, information is accessible online at https://www.poisonhelp.org/help. Overdose symptoms can include headaches, confusion, fever, dizziness, nausea, vomiting, bloody diarrhea, shortness of breath, sweating, flushing, cold, clammy skin loss of body movement, coma (loss of consciousness for a while), seizures, and more.

Storage

However, you shouldn't dispose of this medication in the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication tightly closed in the original container and out of the reach of children. If you do not have access to a take-back program, you can find more information at the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p). Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Always lock safety caps and store medications up and away, out of sight, and away from young children to prevent poisoning. http://www.upandaway.org Unused medications should be disposed of in special ways to prevent pets, children, and other people from consuming them.

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Side effects

Call your doctor if you have any unusual problems while you are taking this medication. You or your doctor can report a serious side effect to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088. Call your doctor right away or seek emergency medical attention if you experience any of the following symptoms: nausea, worsening chest pain, rash, itching, or difficulty breathing or swallowing. Isosorbide may also have additional side effects. Isosorbide may cause side effects. Inform your doctor if any of the following side effects occur or worsen, including those listed in the SPECIAL PRECAUTIONS section: nausea, worsening chest pain, rash, itching, or difficulty breathing or swallowing.

Contraindications

You should be aware that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Alcohol can exacerbate the side effects of isosorbide. Ask your pharmacist for a list of the ingredients. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Mention any of the following: aspirin; beta blockers such as atenolol (Tenormin, Tenoretic), carteol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), Before taking isosorbide, tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. Do not try to change the times or the way that you take isosorbide in order to avoid headaches because then the medication may not work as well. Call your doctor right away if you find out you're pregnant while taking isosorbide, let them know if you're having surgery, including dental work, and ask them if drinking alcohol is safe while taking the medication. You should know that you may experience headaches every day during your treatment with isosorbide, so take extra precautions to prevent falling. These headaches could indicate that the medication is performing as intended. Get up gradually and leave your feet on the floor for a few minutes before standing up to avoid this issue. Tell your doctor if you think you may be dehydrated, if you've recently had a heart attack, if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (a thickening of the heart muscles), and if you're pregnant, planning to become pregnant, or nursing. Your doctor may need to change the doses of your medications or monitor you closely for side effects. For the treatment of your headaches, your doctor might advise taking a painkiller. Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

Will it affect my sex life?

Isosorbide mononitrate or dinitrate is not likely to affect your sex life. However, do not take medicines for erection problems if you are taking isosorbide mononitrate or dinitrate. These include: avanafil sildenafil (including Viagra) vardenafil tadalafil Some people with angina worry that having sex will trigger an angina attack, but the risk of this happening is low. It is as safe as other forms of exercise with similar levels of effort. Talk to your doctor if you are having problems with your sex life.

What drug class does isosorbide belong to?

Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.

Do I need to avoid playing sports?

You do not need to avoid playing sports due to taking isosorbide mononitrate or dinitrate. It's important to stay active if you have angina or heart failure. It will help if you can: build up your activity level gradually and take regular breaks keep your GTN tablets or spray with you in case you need them use your tablets or spray before starting exercise, if you need to Talk to your doctor if you're not sure it's safe for you to exercise.

Is there any food or drink I need to avoid?

Apart from limiting alcohol, you can eat and drink normally while you are taking isosorbide mononitrate or dinitrate. However, if you have angina you may have a higher risk of having a heart attack or stroke. You can help reduce your risk of problems like these by: eating a balanced diet cutting down on alcohol losing weight if you are overweight Drinking alcohol can increase the effects of isosorbide mononitrate and dinitrate. It can make your blood pressure too low and you may feel dizzy, lightheaded or sleepy.

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Testimonials
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timmyspan Mar 20, 2018, 3:58:32 PM

Saproterin (Tetrahydrobioterine, BH4) is a cofactor for nitric oxide synthetase. and/or alcohol may potentiate the hypotensive effect of the tablets. beta blockers, calcium antagonists, vasodilators, ACE-inhibitors, monoamine oxidase inhibitors etc. The concurrent intake of ISDN with ACE-inhibitors or arterial vasodilators could be a desirable interaction unless the antihypertensive effects are excessive in which case consider reducing the dose of one or both drugs.

Dan Randall Jul 23, 2019, 5:00:38 AM

Use during the periods of pregnancy and a lactation is possible in cases when the expected advantage for mother exceeds probable negative impact on a fruit or the child. ), acetylsalicylic acid and isosorbide of mononitrate strengthening of anti-anginal effect is possible. A form of release • of the Tablet on 20 mg or 40 mg, in packing of 30 tablets.

Louie McCoy Apr 15, 2020, 7:30:32 AM

Dosing: Geriatric Dosing: Adjustment for Toxicity If patient experiences intolerable side effects, dose may be reduced to as little as one-half tablet 3 times daily; dose should be titrated upward as soon as tolerated. Note: May also consider use of hydralazine 3 times daily and isosorbide dinitrate 3 times daily as separate components rather than this combination tablet (ACC/AHA/HFSA [Yancy 2017]; ACCF/AHA [Yancy 2013]; Meyer 2019). Dosing: Adult Heart failure with reduced ejection fraction (HFrEF): Note: As additional therapy for persistent NYHA class III or IV HFrEF despite optimal medical therapies or for patients who cannot tolerate an ACE inhibitor, ARB, or angiotensin II-neprilysin inhibitor (ACCF/AHA [Yancy 2013]; Colucci 2019). Oral: Initial: One tablet (containing 20 mg of isosorbide dinitrate and 37.5 mg of hydralazine) 3 times daily; titrate dose in 2 to 4 weeks to a maximum dose of 2 tablets (containing a total of 40 mg of isosorbide dinitrate and 75 mg of hydralazine) 3 times daily.

matheus Oct 19, 2013, 7:32:22 PM

Firstly ask your doctor or health care professional.Severe hypotension, particularly with upright posture, may be caused by even small doses of Isordil. You are lucky, our company products quality and safe medicine for cheap price. The patients who have hypertension, who may be volume depleted should take this drug with caution. If you take Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) together with Isordil it can increase the blood pressure lowering effects and may cause excessive blood pressure reduction. Isordil should be taken by mouth with a glass of water without food.

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