Description
Irbesartan is an angiotensin receptor blocker (ARB) that is used to treat hypertension and diabetic nephropathy. Patients who do not respond well to monotherapy or who are not anticipated to respond well to combination therapy may also benefit from using this medication. Irbesartan was granted FDA approval on 30 September 1997., ARBs are not connected with a dry cough, unlike angiotensin converting enzyme inhibitors.
Dosage
Comments: It has been demonstrated that this medication slows the progression of nephropathy, as indicated by the occurrence of doubling serum creatinine levels or ESRD (need for dialysis or renal transplantation). Detailed Irbesartan dosage information Initial dose: 150 mg orally once per day -Maintenance: 150 to 300 mg orally once per day Maximum dose: 300 mg orally once per day Comments: -Can be used alone or in conjunction with other antihypertensive medications. Use: Diabetic nephropathy treatment in individuals with type 2 diabetes, hypertension, elevated serum creatinine, and proteinuria (greater than 300 mg/day) Use: Treatment of hypertension. Usual Adult Dose for Diabetic Nephropathy: Usual Adult Dose for Hypertension:
Missed dose
In order to catch up, do not double the dose. If it is near the time of the next dose, skip the missed dose. Use the missed dose as soon as you remember it if you do. Take your subsequent dose at the scheduled time.
Overdose
Fast heartbeats or fainting may be signs of an overdose. Call 1-800-222-1222 for poison help if you need immediate medical attention.
Storage
You shouldn't flush this medication down the toilet, though. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication out of the reach of children and tightly closed in the original container. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
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Some patients might receive an additional benefit by increasing the dose to 100 mg, once daily. If any of the above-mentioned side effects persist for long, consult your doctor right away. Get regular tests of creatinine, urea, and potassium in your blood. If you have had a medical history of liver disease, or dehydration, inform your doctor before starting with this medication.
Irbesartan at a dose of 150 mg once daily generally provides a better 24 hour blood pressure control than 75 mg. In particular, the addition of a diuretic such as hydrochlorothiazide has been shown to have an additive effect with irbesartan (see section 4.5). No dosage adjustment is necessary in patients with impaired renal function. However, initiation of therapy with 75 mg could be considered, particularly in haemodialysed patients and in the elderly over 75 years.
Diabetic nephropathy is a complication of type 2 diabetes which causes the kidneys to not work properly. Irbesartan is also used to treat high blood pressure with diabetic nephropathy. This medicine is available only with your doctor's prescription. If it continues for a long time, the heart and arteries may not function properly.
In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease. In particular, the addition of a diuretic such as hydrochlorothiazide has been shown to have an additive effect with Irbesartan Zentiva (see section 4.5). A lower starting dose (75 mg) should be considered for patients undergoing haemodialysis (see section 4.4).
Angiotensina II è un potente vasocostrittore (una sostanza che restringe i vasi sanguigni). La dose solitamente raccomandata è 150 mg una volta al giorno. • Il medicinale può essere ottenuto soltanto con prescrizione medica.
In particular, the addition of a diuretic such as hydrochlorothiazide has been shown to have an additive effect with irbesartan (see section 4.5). No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease. No dosage adjustment is necessary in patients with impaired renal function.
The tablet should be swallowed with a sufficient amount of fluid (e.g. In particular, the addition of a diuretic such as hydrochlorothiazide has been shown to have an additive effect with irbesartan (see section 4.5). Irbesartan 150mg film-coated Tablets at a dose of 150 mg once daily generally provides a better 24 hour blood pressure control than 75 mg. No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. Although consideration should be given to initiating therapy with 75 mg in patients over 75 years of age, dosage adjustment is not usually necessary for older people.