Side effects
For more details, consult your physician or pharmacist. For medical advice about side effects, contact your doctor. Oral: Common side effects of indomethacin suspension and capsules include the following: headache dizziness vomiting diarrhea constipation ringing in the ears Topical: Common side effects of indomethacin suppositories include the following: headache dizziness vomiting diarrhea constipation irritation of the rectum constant feeling of the need to empty the bowel ringing in the ears Injectable: Side effects of indomethacin injection in infants are uncommon, but may include: bleeding coagulation problems renal failure This is not a complete list of indomethacin side effects. See the "Indomethacin Precautions" section. Indomethacin has been linked to serious side effects. If any side effect bothers you or does not go away, let your doctor know right away. Call the FDA at 1-800-FDA-1088 to report side effects.
Interactions
Before combining Indocin with any other medications, particularly: If you use an antidepressant, check with your doctor before taking Indocin. Drug interactions with indocin (more information) Not all possible drug interactions are covered in this list. Prescription, over-the-counter, vitamin, and herbal medications as well as Indocin itself may have an impact on other medications. You may bruise or bleed more easily if you take certain antidepressants along with an NSAID. This is not an exhaustive list. cyclosporine, lithium, methotrexate, probenecid, blood thinners like warfarin, coumadin, or jantoven, as well as other NSAIDs like aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, meloxicam, and others.
Contraindications
You may become more groggy or lightheaded if you consume alcohol or marijuana (cannabis). Avoid tanning booths and sunlamps. Inform your surgeon or dentist of everything you use, including prescription, over-the-counter, and herbal products. Inform your doctor or pharmacist if you have any allergies before taking indomethacin, aspirin, or other NSAIDs (such as naproxen, ibuprofen, or celecoxib). Tell your doctor or pharmacist about all of your medical conditions before taking this medication, especially if you have: asthma (including a history of breathing problems getting worse after taking aspirin or other NSAIDs), bleeding or clotting issues, nasal polyps, heart disease (including a history of heart attacks), high blood pressure, liver disease, stomach/intestinal/esophageal problems (including bleeding, ulcers, and recurrent heartburn), and stroke. Women of childbearing age should discuss the benefits and risks of using this medication with their doctor(s) before beginning. Children using this medication should exercise caution. Children may be more sensitive to the side effects of this drug, especially serious liver problems. Consult your doctor before breast-feeding. To learn more, speak with your physician or pharmacist. Your risk of stomach bleeding may increase if you regularly use alcohol and/or tobacco, especially when taking this medication. With your doctor, go over the advantages and disadvantages of the proposed course of action. Until you can do something safely, avoid operating machinery, driving, or doing anything else that requires alertness. Drink plenty of fluids as prescribed by your doctor to avoid dehydration, and inform them right away if you notice a change in the volume of your urine. Between 20 and 30 weeks of pregnancy, if your doctor decides you need to take this medication, you should take it in the shortest amount of time possible at the lowest effective dose. It is not recommended for use in pregnancy from 20 weeks until delivery. When taking NSAIDs, including indomethacin, kidney issues can occasionally arise. Limit alcohol and stop smoking. Don't spend too much time outside. While taking this medication, older adults may be more susceptible to mental/mood changes, kidney issues, heart attacks, strokes, stomach/intestinal bleeding, and kidney problems. Dehydration, heart failure, kidney disease, being an older adult, taking certain medications, and having any of these conditions increase your risk of complications (see also the Drug Interactions section). Talk to your doctor if you are using marijuana (cannabis). Get more information by speaking with your pharmacist. If you are expecting a child or plan to have a child, let your doctor know. If you experience skin blisters or redness, or if you get a sunburn, call your doctor right away. You might feel groggy or lightheaded after taking this medication. This medication enters breast milk and could have negative effects on a nursing infant. This medication has the potential to harm an unborn child and interfere with a normal labor and delivery. You might become more sensitive to the sun as a result of this medication. This medicine may cause stomach bleeding. This product might include inactive components that could lead to allergic reactions or other issues. When outdoors, apply sunscreen and don protective gear. Using this medication after 30 weeks of pregnancy is not advised.
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indomethacin (Indocin, Indocin-SR) naproxen (Anaprox, Naprelan, Naprosyn, Aleve) Combining ARBs, ACE inhibitors, or aliskiren (Tekturna) increases risk of hypotension (low blood pressure), hyperkalemia, and reduces kidney function compared to each drug used alone, and there is no additional benefit on preventing end stage kidney disease or death. Metoprolol can mask the early warning symptoms of low blood sugar (hypoglycemia) and should be used with caution in patients receiving treatment for diabetes. Aliskiren and losartan should not be combined in patients with diabetes or with renal impairment.
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) used for treating fever, pain, and inflammation. Reduction of prostaglandins also diminishes the function of platelets and the ability of the blood to clot. Aspirin inhibits the function of platelets for prolonged periods of time so it is used to reduce the risk of another stroke or heart attack in patients who have had a previous stroke or heart attack. Xarelto, in combination with aspirin, is indicated to reduce the risk of major cardiovascular events (cardiovascular death, myocardial infarction, and stroke) in patients with chronic coronary artery disease or peripheral artery disease. Xarelto is used to reduce the risk of stroke and blood clots in patients with atrial fibrillation not due to a heart valve problem; to treat and reduce the risk of deep vein thrombosis (DVT, blood clots in the veins of the legs) and pulmonary embolism (PE, blood clots in the lungs); and reduce the risk of blood clots in the legs and lungs of patients who have just had hip or knee replacement surgery.
Calcium carbonate – containing antacids, nexium, and omeprazole: they lower chromium absorption and they should be taken 2 – 4 hours apart. Chromium is found in the body in the organic active form in the trivalent state (as a part of GTF) or bound to beta globulin protein. Brewer`s yeast is the best food source of chromium.
Voltaren gel, or diclofenac sodium 1%, has been available as a prescription product in America since 2007. Despite the lower absorption, patients should avoid combining oral and topical NSAIDs. A new over-the-counter medication is now available at Sona Pharmacy! Oral NSAIDs to look for on labels include: OTC Oral NSAIDs: Advil (ibuprofen) Aleve (naproxen) Midol Extended Relief (naproxen) Motrin (ibuprofen) Naprosyn (naproxen) Prescription Oral NSAIDs: Celebrex (celecoxib) Feldene (piroxicam) Indocin (indomethacin) Mobic (meloxicam) Toradol (ketorolac) Ketoprofen Etodolac Diclofenac All NSAIDs, topical or oral, should be avoided in patients with cardiac conditions or renal insufficiency. Voltaren Arthritis Pain has advantages over oral NSAIDs due to a decreased amount of absorption into the body.