Description
Additionally, superficial basal cell carcinoma, a specific type of skin cancer, can be treated with imiquimod. Warts cannot be cured by iquiquimod, and the medication may cause the development of new warts. Imiquimod helps to relieve and control wart production but does not directly combat the viruses that cause warts. Actinic keratoses, a skin condition affecting the scalp and face, are also treated with imiquimod. A toll-like receptor 7 agonist, imiquimod modifies immune response. Warts on the genital and anal skin can often be treated topically with imiquimod. Imiquimod is particularly useful on areas where surgery or other treatments may be difficult, complicated or otherwise undesirable, especially the face and lower legs. The rectum, penis, and vaginal warts are not treated with it.
Dosage
Apply imiquimod cream exactly as prescribed. Before the appropriate amount of time has passed, avoid bathing or getting the treated area wet. Don't apply imiquimod cream to your skin for any longer than advised. Carefully adhere to the instructions on your prescription label. For actinic keratosis, imiquimod cream is typically applied once per day for two days per week, three to four days apart, for a total of 16 weeks. It is typical to apply imiquimod cream once daily for three days a week for 16 weeks to treat external genital and perianal warts. imiquimod cream is typically applied once daily for six weeks, five days a week, for superficial basal cell carcinoma. The length of time your doctor advises is appropriate for leaving the cream on the affected area or areas. Depending on the type of skin condition that imiquimod cream is used to treat, it must be applied to the skin for a different amount of time.
Overdose
Call your neighborhood poison control center right away if you accidentally apply too much imiquimod or if someone swallows imiquimod cream. If necessary, seek emergency medical help.
Storage
At 4° to 25°C, keep things in storage. Store away from sunlight in a cool, dry environment.
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It should remain on the skin for 6 to 10 hours and the area should then be washed with mild soap and water. Aldara works by helping the immune system of the body produce natural substances that help to fight the HPV virus. The HPV infection can be passed on by sexual contact such as vaginal and anal sex, even if there are no visible warts at the time. If there is any unused cream in a sachet it should be disposed of immediately and not used for the next application.
Apply a thin layer of this medication onto the clean, dry wart area and rub gently into skin until the cream is absorbed. Leave the medication on the skin area for 8 hours, and then remove it by washing the treated area with mild soap and water. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.
If this does happen by accident, wash it off with warm water as soon as possible. There are two strengths of cream available - 3.75% (brand name Zyclara®) and 5% (brand names Aldara® and Bascellex®). If the area has still not cleared after 16 weeks of using the cream, you must stop using imiquimod and see your doctor for further advice.
On 28 April 2016, orphan designation (EU/3/16/1653) was granted by the European Commission to Galderma R&D, France for resiquimod to be used in the treatment of cutaneous T-cell lymphoma. In an animal disease model, systemic administration of resiquimod-loaded nanoparticles has been shown to improve response rates to cancer immunotherapy with a checkpoint inhibitor through stimulation of tumor-associated macrophages. It is used as a topical gel in the treatment of skin lesions such as those caused by the herpes simplex virus and cutaneous T cell lymphoma, and as an adjuvant to increase the effectiveness of vaccines. Resiquimod (R-848) is a drug that acts as an immune response modifier, and has antiviral and antitumour activity. It has several mechanisms of action, being both an agonist for toll-like receptor 7 and 8, and an upregulator of the opioid growth factor receptor.