Treatment for non-insulin dependent diabetes melitus (NIDDM) involves the use of glibenclamide. The juvenile-onset type of diabetes, in which the pancreas has lost all or nearly all of its capacity to secrete insulin, as well as patients who have had complete pancreatectomies, render it ineffective. Such patients require insulin, and efforts to control them with oral therapy are risky and doomed to failure.
Change over from insulin to Glibenclamide: The mildly diabetic patient whose insulin requirement is fewer than 20 units daily, can be started on the initial dosage of Glibenclamide with immediate discontinuation of insulin. Daily dose of ½ tablet (2.5 mg) may be continued as maintenance therapy if good control has been achieved. For daily doses over 10 mg, two divided doses may be used. If the need for insulin is moderate or high, the switch should be made gradually by administering both insulin and glibenclamide at the same time and gradually lowering the insulin dose. If the outcome is poor, increasing the daily dose by increments of 12 tablet (2.5 mg) every 3-5 days, up to a maximum of 3 tablets, is required. Initially stabilization dosage: Glibenclamide half tablet (2.5 mg) should be taken initially during or immediately after breakfast. 3-5 days after initiation of the drug, the blood sugar level and urine sugar level should be checked. When switching from other oral anti-diabetics with a similar mechanism of action, patients should be given 1/2 to 1 tablet of glibenclamide. Only NIDDM with relatively recent onset that is being managed with low doses of insulin will transition from insulin to glibenclamide. This should preferably be done in hospital or with daily medical supervision. A patient needs insulin to get through a critical situation when their insulin needs are increased, such as during a fever, surgery, or trauma. Glibenclamide alone is insufficient in these situations.
Must be kept dry and below 30 degrees Celsius.
Leukopenia, thrombocytopenia, and other hemopoietic reactions caused by allergies are occasionally seen. A few possible side effects are headache, dizziness, nausea, vomiting, epigastric pain, and weakness. Glibenclamide is well tolerated.
NIDDM is treated with glibenclamide. It is ineffective in completely pancreatectomized patients and in juvenile-onset type of diabetes, in which the pancreas has lost all or nearly all of its capacity to secrete insulin. Such patients need insulin, and attempts to control them with oral therapy are risky and doomed to failure.
Regardless of the drug selected, a concerted effort must be made by the patient and the doctor to reduce the patient's weight as a necessary component of diabetic treatment. The most crucial aspect of diabetes treatment is weight loss.
Which is better glibenclamide or metformin?
Conclusions At short term, in women with gestational diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin.
Which generation is glibenclamide?
The second generation sulfonylureas include glyburide (also known as glibenclamide), gliclazide, glipizide, and glimepiride, which are oral hypoglycemic agents that are widely used in therapy of type 2 diabetes.
Why glibenclamide is used in type 2 diabetes?
Glibenclamide works by increasing the amount of insulin that your pancreas produces. This helps to reduce the amount of sugar in your blood.
Is glibenclamide better than metformin?
Treatment failure was higher with metformin than with glibenclamide. Conclusions At short term, in women with gestational diabetes requiring drug treatment, glibenclamide is clearly inferior to both insulin and metformin, while metformin (plus insulin when required) performs slightly better than insulin.
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