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Disulfiram
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disulfiram 500 mg

Alcohol addiction is treated with the carbamate derivative disulfiram.

Other names for this medication:
Antabuse

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Description

Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the disulfiram-alcohol reaction. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. Disulfiram doesn't seem to have an impact on how quickly the body gets rid of alcohol. When a patient taking disulfiram consumes even trace amounts of alcohol, they experience a very unpleasant reaction. Disulfiram is not tolerable when administered for an extended period of time; rather, the longer a patient is on therapy, the more exquisitely sensitive he becomes to alcohol. This response, which is proportional to the dosages of alcohol and disulfiram, will continue as long as alcohol is still being metabolized.

Dosage

Avoid all alcoholic foods and beverages, vinegars, and sauces. Disulfiram comes in tablets to take by mouth. Do not drink any alcoholic beverages (including wine, beer, and medications that contain alcohol such as cough syrup) while taking disulfiram, during the 12-hour period before you take your first dose, and for several weeks after stopping the drug. Never take it in larger or smaller amounts or more frequently than your doctor has instructed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. If you find it difficult to swallow the tablets, break them up and mix the medication with water, milk, coffee, tea, soft drinks, or fruit juice. It needs to be taken once daily. Follow the disulfiram instructions precisely.

Missed dose

When you remember, take the missed dose. Unless your doctor instructs you otherwise, take the remaining doses of the day at regularly spaced intervals.

Overdose

Call 911 right away if the victim has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused. In case of overdose, call the poison control helpline at 1-800-222-1222. You can find information online at https://www.poisonhelp.org/help.

Storage

This medication should not, however, be flushed down the toilet. Instead, using a medication take-back program is the best way to get rid of your medication. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Store this medication out of children's reach in the tightly closed, original container. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. Always lock safety caps and put medication in a secure spot right away that is up and out of the way and out of reach of young children to prevent poisoning. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

Drug interaction information for disulfiram Drug class: medications used to treat alcohol dependence Patient resources Advanced Reading Other brands Antabuse Professional resources Prescribing Information Related treatment guides Alcohol Dependence Prescription and over-the-counter medications, vitamins, and herbal products, among others, may interact with disulfiram. Any new or discontinued medications should be disclosed to all of your healthcare providers.

Interactions

Drug interaction information for disulfiram Drug class: medications used to treat alcohol dependence Patient resources Advanced Reading Other brands Antabuse Professional resources Prescribing Information Related treatment guides Alcohol Dependence Prescription and over-the-counter medications, vitamins, and herbal products, among others, may interact with disulfiram. Any new or discontinued medications should be disclosed to all of your healthcare providers.

Contraindications

Driving and using large machinery shouldn't be done until you know how disulfiram affects you. Do not take disulfiram if you: are allergic to disulfiram or to any of its ingredients are allergic to thiuram derivatives used in pesticides and rubber vulcanization have recently taken metronidazole, paraldehyde, alcohol, or alcohol-containing preparations such as cough syrups and tonics have severe myocardial disease or coronary occlusion have psychoses Disulfiram has been associated with serious side effects, such as liver toxicity. If you experience any, or all, of the following signs or symptoms of liver toxicity, contact your doctor right away. Disulfiram can also cause drowsiness and blurred vision.

Is disulfiram an agonist or antagonist?

The physician should instruct relatives accordingly. Disulfiram is an alcohol antagonist drug.

What is the action of disulfiram in pharmacology?

Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms.

What are disulfiram tablets used for?

Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.

Is disulfiram a benzodiazepine?

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice. Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.

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Bran Mar 8, 2015, 12:27:37 PM

They can be prescribed and used during alcohol detox to relieve symptoms of withdrawal. Acamprosate helps the brain redevelop normal function independent of alcohol by blocking the positive feelings that comes with drinking, lessening the chance of relapse. Benzodiazepines Benzodiazepines are anti-anxiety medications commonly used as sedatives.

pizan2003 Feb 27, 2021, 10:43:36 AM

Contraindications Hypersensitivity to nitroimidazole derivatives; first trimester of pregnancy in patients with trichomoniasis. Hepatic Impairment: Patients with severe hepatic disease metabolize drug slowly; use caution and lower dose. If administered by intermittent infusion, discontinue primary fluid during infusion. ADULTS: IV 15 mg/kg loading dose infused over 1 hr (approximately 1 g for a 70 kg adult); then 7.5 mg/kg infused over 1 hr q 6 hr (approximately 500 mg for a 70-mg adult). Elderly: Monitoring serum levels may be necessary for proper dosing.

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Recent research from the United States and Switzerland indicates gene therapies utilizing antisense and antisurvivin treatments have tremendous potential. Sources of information are listed at the bottom of the article. [6] What Does this Mean for the Future of Mesothelioma Treatment? In nature, apoptosis is triggered by certain hormonal processes. Conversely, people with cancer, such as malignant mesothelioma, show lower than normal rates of apoptosis.

zlin143 Aug 17, 2021, 7:21:24 AM

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa (as monotherapy). Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.

Julene Thompson Sep 16, 2016, 7:07:12 AM

Physicians' Desk Reference, (PDR), 53rd edition. As of 2000, however, calcium carbimide is still not approved for use in the United States. Alcohol (ethanol) is normally metabolized first to acetaldehyde, which is then quickly metabolized further so that levels of acetaldehyde are ordinarily quite low in the body (acetaldehyde is toxic).

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