Description

Diltiazem has been used for a wide range of off-label purposes in addition to its primary FDA-approved uses, including the treatment of anal fissures (in topical formulations), the prevention of migraines, the treatment of pulmonary hypertension, and the relief of cramps that are brought on by rest in the lower extremities. It belongs to the group of medications known as non-dihydropyridine calcium channel blockers and was given FDA approval in 1982. Diltiazem, a powerful vasodilator, is used clinically to treat hypertension, atrial fibrillation, atrial flutter, and chronic stable angina. Compared to dihydropyridine drugs, such as , that preferentially act on vascular smooth muscle and that directly acts on the heart muscle, diltiazem displays an intermediate specificity to target both the cardiac and vascular smooth muscle. A derivative of benzothiazepine with antihypertensive and vasodilating properties is diltiazem. The main way it works is by preventing calcium from entering cardiac and vascular smooth muscle during depolarization. It also has other mechanisms of action. Diltiazem is marketed under numerous brand names, with Cardizem and Tiazac being the most popular ones. It is typically offered in extended-release oral and intravenous formulations.

Dosage

Carefully adhere to the instructions on your prescription label. Diltiazem injections typically range in dosage from 20 to 25 mg for a single injection, then 10 to 15 mg every hour for up to 24 hours. Follow your doctor's instructions for taking this medication exactly. The dose may be increased slowly over time until treatment goals are achieved. The following factors may influence the dosage your doctor prescribes: the condition being treated; other medical conditions you have; other medications you are taking; and how you react to this drug. Oral: The usual dose range of oral diltiazem for the treatment of hypertension is 180 to 360 mg daily. The typical oral diltiazem dosage range for treating chest pain is 120 to 480 mg per day. According to your needs, your doctor will modify the frequency and dosage of diltiazem.

Missed dose

If you miss a dose, don't take a second one to make up for it. Skip the missed dose and carry on with your regular dosing schedule, though, if it is almost time for the subsequent dose. If you miss a dose, take it as soon as you remember.

Overdose

Immediately dial 911 for emergency services if the victim has collapsed, experienced a seizure, is having difficulty breathing, or cannot be aroused. In case of overdose, call the poison control helpline at 1-800-222-1222. You can find information online at https://www.poisonhelp.org/help. Slow, rapid, or irregular heartbeat, difficulty breathing, seizures, dizziness, confusion, nausea, and increased sweating are all possible overdose symptoms.

Storage

You shouldn't flush this medication down the toilet, though. Instead, using a medication take-back program is the best way to get rid of your medication. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication in the container it came in, tightly closed, and out of reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and store medications up and away, out of sight, and away from young children to prevent poisoning. http://www.upandaway.org Unused medications should be disposed of in special ways to prevent pets, children, and other people from consuming them.

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Side effects

If you experience any of the following: For medical guidance on side effects, contact your doctor. the following are possible diltiazem side effects: Effects of Diltiazem (more information) If you experience any of the following symptoms of a diltiazem allergy: hives; difficulty breathing; swelling of your face, lips, tongue, or throat, seek emergency medical attention. This is not a complete list of side effects and others may occur. Call 1-800-FDA-1088 to contact FDA and report side effects. slow heartbeats; pounding heartbeats or fluttering in your chest; a light-headed feeling, like you might pass out; shortness of breath (even with mild activity), swelling, rapid weight gain; nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. swelling, fainting, drowsiness, headache, nausea, or a rash.

Interactions

For more information, consult your physician or pharmacist. Especially tell your doctor if you take: Atazanavir (Reyataz) Benzodiazepines such as Midazolam (Versed) Triazolam (Halcion) Beta blockers such as Atenolol (Tenormin) Metoprolol (Toprol XL, Lopressor) Carvedilol (Coreg) Bisoprolol (Zebeta) Betaxolol (Kerlone) Nebivolol (Bystolic) Propranolol (Inderal) Labetalol (Trandate) Nadolol (Corgard) Buspirone (Buspar) Carbamazepine (Tegretol) Cimetidine (Tagamet) Cyclosporine (Gengraf, Neoral, Sandimmune) Digoxin (Lanoxin) Statins such as Lovastatin (Altoprev, Mevacor) Simvastatin (Zocor) Quinidine Rifampin Clonidine This is not a complete list of diltiazem drug interactions. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Contraindications

Inform your doctor and pharmacist about all other prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are currently taking or intend to take, and ask for a list of the ingredients from your pharmacist. Atazanavir (Reyataz), benzodiazepines such as midazolam (Versed) and triazolam (Halcion), beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol, metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Inderal, If you have an allergy to diltiazem, any other medications, or any of the ingredients in diltiazem, let your doctor and pharmacist know before taking the medication. If you become pregnant while taking diltiazem, call your doctor right away. If you are having surgery, including dental surgery, let your doctor or dentist know that you are taking diltiazem. Tell your doctor if you have or have ever had a myocardial infarction (MI), a digestive system narrowing or blockage, low blood pressure, or heart, liver, or kidney disease. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

What are the side effects of diltiazem CD?

Dizziness, lightheadedness, weakness, nausea, flushing, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To lower the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Can I drink alcohol with it?

Yes, you can drink alcohol with diltiazem. However, it's best to not drink alcohol for a few days after starting diltiazem or if your doctor increases your dose. Wait until you know how the medicine affects you. Drinking alcohol can increase the blood pressure-lowering effect of diltiazem, which can make you feel dizzy or lightheaded.

What is diltiazem powder used for?

Doctors commonly prescribe diltiazem to treat high blood pressure and to control the type of chest pain known as angina.

What is diltiazem used for and side effects?

Diltiazem is used to prevent chest pain (angina). It may help to increase your ability to exercise and decrease how often you may get angina attacks. Diltiazem is called a calcium channel blocker. It works by relaxing blood vessels in the body and heart and lowers the heart rate.

How long does diltiazem take to work for fissures?

It takes up to two years to regain the normal skin strength associated with a fissure. Most thrombosis will resolve within two weeks.

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