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Digoxin
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digoxin medication dosage

Cardiac glycosides given orally and intravenously Rapid ventricular response is more likely when used in WPW patients. Used for CHF and treatment/prophylaxis of supraventricular tachyarrhythmias

Other names for this medication:
Digifab

Similar Products:
Amiodarone, Lisinopril, Nimotop, Hydrochlorothiazide, Nimodipine, Cordarone, Warfarin

Description

Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients. 2) To increase myocardial contraction in children diagnosed with heart failure. 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation. When clinically feasible, digoxin should be given to adults with heart failure in combination with a diuretic and an ACE inhibitor for the best results.

Dosage

By oral administration: Rapid digitalization: 1-1.5 mg in divided doses over 24 hours Less urgent digitalization: 250-500 micrograms daily (higher dose may be divided) Maintenance: 62.5-500 micrograms daily (higher dose may be divided) depending on renal function and in atrial fibrillation on heart rate response. The typical range is 125–250 micrograms per day (lower doses may be appropriate in elderly patients). Usual dosage: 125–250 micrograms per day (lower dose may be divided), depending on renal function and on the heart rate response in atrial fibrilation.

Missed dose

To make up for a missed dose, don't take a second one. If the next dose is almost due, skip the missed one and carry on with your regular dosing schedule. Take the missed dose as soon as you remember it.

Overdose

Immediately dial 911 for emergency services if the victim has collapsed, experienced a seizure, is having difficulty breathing, or cannot be aroused. In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help.

Storage

You shouldn't flush this medication down the toilet, though. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication tightly closed in its original container away from the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. Keep it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's garbage/recycling department. Always lock safety caps and put medication in a secure spot right away that is up and out of the way and out of reach of young children to prevent poisoning. http://www.upandaway.org To make sure that pets, kids, and other people cannot consume leftover medications, they should be disposed of in a specific manner.

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Side effects

It is safe to take digoxin during pregnancy. Anorexia, nausea, vomiting, diarrhea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucinations, depression, arrhythmia, heart block, intestinal ischaemia, gynecomastia on long-term use, and thrombocytopenia have all been reported as side effects of excessive dosage.

Interactions

Ask your doctor or pharmacist for more information. Tell your doctor right away if you take any of the following medications: antacids like Tums, Citrical, or Maalox, verapamil (Calan), amiodarone (Cordarone), propafenone (Rythmol), indomethacin (Indocin), itraconazole (Sporanox), alprazolam (Xanax), spironolactone (Aldactone), diphenoxy Inform your doctor about all of the medications you take, including any prescription and over-the-counter drugs, vitamins, and herbal supplements.

Contraindications

Digoxin can cause dizziness or blurred vision. Do not drive or operate heavy machinery until you know how digoxin affects you. If you have a condition known as ventricular fibrillation or are allergic to digoxin or digitoxin, you should avoid taking digoxin. Digoxin has been linked to a number of serious side effects, including AV (atrioventricular) block, which should be reported as soon as possible if you experience any of the following symptoms: dizziness, confusion, or a pounding in the chest. Wolff-Parkinson-White Syndrome, which is characterized by an abnormal electrical pathway in the heart, should also be reported as soon as possible.

Is the digoxin a beta blocker?

Digoxin and metoprolol belong to different drug classes. Digoxin is a cardiac glycoside and metoprolol is a beta-blocker.

What are the indications for digoxin?

Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients. 2) To increase myocardial contraction in children diagnosed with heart failure. 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.

What is difference between digoxin and Digitoxin?

It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function.

Is Toloxin the same as digoxin?

Digoxin has been marketed in Canada since 1936. It is currently marketed under the following brand names: Lanoxin, Toloxin, Apo-digoxin, PMS-digoxin, and Digoxin Injection C.S.D. Digoxin is used to treat mild to moderate heart failure by improving heart pumping activity and improving the symptoms of heart failure.

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Testimonials
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David Ringhofer Jun 3, 2011, 10:00:41 AM

It is generally believed that the amount of digoxin in breast milk that a breast-fed infant would receive is not likely to affect the infant. Your child’s doctor will want to closely monitor the effectiveness of this medication for your child. Pregnancy: Digoxin should be taken by pregnant women only if clearly needed. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

JayceeZ Jul 22, 2018, 6:47:36 AM

Moreover, it may be used to convert paroxysmal supraventricular tachycardia to sinus rhythm. READ THIS NEXT: Soursop vs Cherimoya – Nutrition Facts It reaches about 5 feet tall, with many large, thick, hairy leaves at the base and tube-shaped, spotted, purple flowers.

Da google Mar 2, 2021, 12:25:06 PM

Serum digoxin concentrations should be monitored prior to initiation of Tykerb and throughout coadministration. This increase in paclitaxel exposure may have been underestimated from the in vivo evaluation due to study design limitations. Digoxin: Following coadministration of Tykerb and digoxin (P-gp substrate), systemic AUC of an oral digoxin dose increased approximately 2.8-fold. Dose adjustment of lapatinib should be considered for patients who must receive concomitant strong inhibitors or concomitant strong inducers of CYP3A4 enzymes. Ketoconazole: In healthy subjects receiving ketoconazole, a CYP3A4 inhibitor, at 200 mg twice daily for 7 days, systemic exposure (AUC) to lapatinib was increased to approximately 3.6-fold of control and half-life increased to 1.7-fold of control.

Lord Goderick Jul 7, 2017, 11:46:58 PM

The usual daily Lanoxin dose is 125 to 250 micrograms (0.125 to 0.25 mg) for patients with normal renal function. More Medicine Information : Fortum (Ceftazidime) Injection Uses, Dose Administration, Side Effects Unless doses lower than those in non elderly patients used.

alikdrova Jun 9, 2016, 11:37:39 AM

Some of the common side effects of Digoxin include nausea, diarrhea, feeling weak or disoriented, headache, weakness, anxiety, depression, or rash. However, if you see any of the following symptoms of a Digoxin allergy, get emergency medical attention: hives, breathing trouble, swelling of the cheeks, tongue, lips, or throat. If you experience a rapid, slow, or irregular heart rate; bloody or black, tarry stools; disorientation, weakness, hallucinations, strange thoughts or behavior; breast enlargement or soreness; hazy or yellowed eyesight, call your doctor at once.

SleepWalker Apr 17, 2019, 10:31:48 AM

Oral Contraceptive (estrogen/progesterone): Coadministration of Latuda (40 mg/day) at steady state with an oral contraceptive (OC) containing ethinyl estradiol and norelgestimate resulted in equivalent AUC and Cmax of ethinyl estradiol and norelgestromin relative to OC administration alone. Given the primary CNS effects of Latuda, caution should be used when it is taken in combination with other centrally acting drugs and alcohol. This suggests that an interaction of Latuda with drugs that are inhibitors or inducers of these enzymes is unlikely. Digoxin dose adjustment is not required when coadministered with Latuda.

Pavel Babin Feb 14, 2011, 6:01:27 PM

Suggested doses are intended only as an initial guide. The maintenance dosage should be based upon the percentage of the peak body stores lost each day through elimination. The possibility of reduced renal function and lower lean body mass should be taken into account when dealing with elderly patients. Children over ten years of age require adult dosages in proportion to their body weight.

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