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cyclophosphamide dose calculation

Detailed drug information for intravenous and oral cyclophosphamide. Includes common brand names, drug descriptions, warnings, side effects and dosing information.

Other names for this medication:
Procytox

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Description

Additionally, cyclophosphamide has been linked to cancer, mutations, birth defects, and sterility. It has been used to treat leukemia and lymphoma. Its side effect, alopecia, has been used for defleecing sheep. precursor of an immunosuppressive and antineoplastic alkylating nitrogen mustard agent, which the liver must activate in order to produce the active aldophosphamide.

Dosage

You should carefully follow your doctor's instructions regarding how much water you should consume each day and how frequently you should empty your bladder. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Do not chew or crush the tablets/capsules. Without first getting your doctor's approval, never up the dosage or take this medication more frequently. Keep the capsules closed. To help prevent kidney and bladder side effects while taking this medication, you must drink more fluids than usual and urinate frequently. Wash your hands thoroughly as soon as possible if you unintentionally come into contact with broken tablets or capsules. Women who are or may become pregnant should not handle this medication or breathe dust from the tablets or capsules because it can be absorbed through the skin and lungs and may harm an unborn child. Tablets and capsules should be taken whole. Exactly as prescribed by your doctor, take this medication by mouth. The dosage is determined by several factors, including your health, weight, treatment response, and any additional therapies you may be receiving (such as radiation or additional chemotherapy drugs). The likelihood of serious side effects could rise while your condition won't get any better any quicker.

Missed dose

To make up for a missed dose, do not take a second one. Skip the missed dose and carry on with your regular dosing schedule, though, if it is almost time for the subsequent dose. Take the missed dose as soon as you remember it.

Overdose

If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Dial 1-800-222-1222 to reach the poison control hotline in the event of an overdose. Additionally, information is accessible online at https://www.poisonhelp.org/help. Black, tarry stools, red urine, unusual bruising or bleeding, unusual tiredness or weakness, a sore throat, a cough, a fever, or other signs of infection, as well as swelling in the legs, ankles, or feet are all indications of overdose.

Storage

Speak with your pharmacy or the regional waste management firm. Unless specifically instructed to do so, avoid flushing medications down the toilet or pouring them into drains. Place nowhere near a bathroom. Keep kids and pets away from all medications. When it is no longer needed or has expired, properly dispose of this product. Put the oral solution in the fridge. Store at room temperature away from light and moisture.

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Side effects

Ask your doctor or pharmacist for more information. Other less severe but more frequent side effects include: nausea, vomiting, loss of appetite, weight loss, diarrhea, temporary hair loss, mouth sores, changes in skin or nail color, menstrual changes, and temporary or permanent sterility. Discuss any side effect that bothers you or does not go away with your doctor. look at the section on drug precautions. Cyclophosphamide use can result in serious side effects. The side effects of cyclophosphamide are not all included in this list.

Interactions

Malignant Diseases: Cyclophosphamide is indicated for the treatment of: Malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma Multiple myeloma Leukemias: chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenousand monocytic leukemia, acute lymphoblastic (stem-cell) leukemia (cyclophosphamide given during remission is ... Pediatric Patients with Minimal Change Nephrotic Syndrome: Cyclophosphamide is prescribed to treat pediatric patients with biopsy-proven minimal change nephrotic syndrome when adrenocorticosteroid therapy has not produced the desired results or when the patient is unable to tolerate it. Malignant diseases: Cyclophosphamide is indicated for the treatment of Hodgkin disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma, multiple myeloma, acute myelogenous and monocytic leukemia, and acute lymphoblastic leukemia (AML).

Contraindications

Lactation. Patients with DM, severe immunosuppression, acute porphyria, pre-existing CV disease, or those at risk for cardiotoxicity impaired liver and kidney function.

Is cyclophosphamide an antineoplastic drug?

Cyclophosphamide is an antineoplastic agent metabolized to active alkylating metabolites with properties similar to those of chlormethine. It also possesses marked immunosuppressant properties. It is widely used, often in combination with other agents, in the treatment of several malignant diseases.

How do you administer cyclophosphamide?

Intravenous administration should preferably be conducted as an infusion. To reduce the likelihood of adverse reactions that appear to be administration rate-dependent (e.g. facial swelling, headache, nasal congestion, scalp burning), cyclophosphamide should be injected or infused very slowly.

What is the mechanism of action of cyclophosphamide?

MECHANISM OF ACTION: Cyclophosphamide is an alkylating agent of the nitrogen mustard type. 2 An activated form of cyclophosphamide, phosphoramide mustard, alkylates, or binds, to DNA. Its cytotoxic effect is mainly due to cross-linking of strands of DNA and RNA, and to inhibition of protein synthesis.

When is mesna required with cyclophosphamide?

Mesna should always be given with ifosfamide and high dose cyclophosphamide if hyperhydration is not being used.

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Testimonials
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Mark Nimzidyne Oct 29, 2010, 11:43:50 PM

diarrhea mouth sores bladder problems, including irritation and bleeding. As a first-line therapy, it is most commonly given orally in combination with Velcade (bortezomib) and dexamethasone (CyBorD or VCd). A cyclophosphamide infusion, or intravenous (IV) cyclophosphamide, can also be used as part of the stem cell harvesting process in combination with colony stimulating factors.

Thomas Thaler Sep 3, 2021, 11:47:00 PM

Fien Apr 25, 2014, 5:27:41 PM

Data from 2 small phase II studies support the use of doxorubicin (in combination with cisplatin with or without capecitabine) in the treatment of metastatic hepatocellular carcinoma, in patients fit enough to tolerate therapy Lee 2004, Park 2006. Data from phase II trials supports the use of doxorubicin in combination with vincristine, cyclophosphamide, and cisplatin Fornasiero 1991 or in combination with cisplatin and cyclophosphamide Loehrer 1994 for the treatment of advanced thymomas. A retrospective review performed across two institutions (with 2 years of follow-up data) also suggests the utility of doxorubicin as a component of TACE Morse 2012. Clinical experience also suggests the utility of doxorubicin (in combination with cisplatin and cyclophosphamide) for palliative management of advanced salivary gland cancers Laurie 2006. Data from a randomized open-label phase III trial supports the use of doxorubicin (in combination with rituximab, cyclophosphamide, vincristine, and prednisone [R-CHOP]) for the management of Waldenström macroglobulinemia Buske 2009.

inderbagga Jun 3, 2022, 12:50:19 PM

Results: Of the 1,088 eligible women, 546 were assigned to receive 5′-DFUR alone and 542 were assigned to receive 5′-DFUR plus CPM. Women 50 years or older concurrently received 20 mg/d of tamoxifen for 2 years in both groups. All patients initially received 5′-DFUR in an oral dose of 1,200 mg/d for 4 weeks, starting 4 weeks after surgery.

Dam Col Jan 17, 2015, 11:53:48 AM

Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Diffuse Large B-Cell Lymphoma (DLBCL) nutrition may have to be redesigned. Foods to Avoid with Cyclophosphamide treatment Acorn : Acorn contains active ingredients such as Folic Acid, Retinol and others. The treatment for Diffuse Large B-Cell Lymphoma (DLBCL) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Diffuse Large B-Cell Lymphoma (DLBCL). In short – the answer to “What Should I Eat” for Diffuse Large B-Cell Lymphoma (DLBCL) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Unda May 12, 2020, 7:26:25 PM

Within this group, 60% of patients achieved CR and 40% achieved PR status. Mechanism of Action Fludarabine is a purine analogue and is metabolized rapidly to F-Ara-ATP, which inhibits DNA synthesis by inhibition of DNA polymerases and prevents elongation of DNA strands through direct incorporation into the DNA molecule. These agents alkylate DNA bases, thereby producing “cross-links” that covalently link the two DNA strands and prevent cell replication.

Nipun Gogia Sep 18, 2013, 7:57:07 PM

Aromatic ring will further increase the distribution of the drug throughout the body. IUPAC nomenclature (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide Classification Cyclophosphamide falls under the category of alkalyting agents. a)2-Chloro-N,N-bis-(2-chloroethyl)-N-methylethan-1-amine b) (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide c)2-Chloro-N-(2-chloroethyl)-N-methylethan-1-amine Q.2 What can be the correct sequence for the action of Cyclophosphamide I. formation of cross linkages in the DNA by the action of metabolites II. Benzimidazole ring can provide the local and faster action of the drug.

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