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Before using any other eye drop products, wait at least five minutes before using Combigan. Glaucoma and elevated eye pressure are both treated with combigan.

Other names for this medication:
Duotrav, Azarga, Istalol, Timoptic, Betimol, Cosopt, Xalacom, Timolol

Similar Products:
Careprost, Lumigan, Moxifloxacin, Latanoprost, Bimatoprost, Brimonidine, Vigamox, Latisse, Cyclomune, Xalatan


Combigan is typically administered twice daily and is available as eye drops. Combigan may be used in conjunction with other eye drop medications, but if more than one eye drop is required, the various medications should be used at least five minutes apart. Combigan should not be taken in two doses at once. After the date indicated on the bottle's expiration, do not use the product. Patients who misuse eye drops or fail to store them properly risk unintentionally contaminating the eyedrop containers. Take your next dose at the scheduled time if it is almost time for the next one. If you miss a dose, don't take it. Use caution if the solution changes color or becomes cloudy. Take the missed dose right away if you forget to do so. Replace the cap immediately after use to avoid contamination. Exactly as directed, use Combigan. You should not use two or more beta-blocking eye drop medications at the same time unless directed to by your physician.


Carefully adhere to the instructions on your prescription label. Combigan should be administered twice daily, one drop into the affected eye(s), spaced roughly 12 hours apart. As directed by your doctor, take this medication exactly as directed.

Missed dose

In order to catch up on a missed dose, do not take more medication. If it is almost time for your next scheduled dose, skip the missed dose. When you remember, use the missed dose.


Call your doctor or the local poison control center if you use too much Combigan, or go to the hospital right away for emergency care.

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Side effects

Call your doctor at once if you have: For medical guidance on side effects, call your doctor. Combigan side effects (more detail) Typical adverse reactions to Combigan include: If you experience any of these symptoms of an allergic reaction to Combigan, seek immediate medical attention: hives; trouble breathing; swelling of your face, lips, tongue, or throat. There may be other side effects; this is not a comprehensive list. Call 1-800-FDA-1088 to contact FDA and report side effects. use of the eye drops may cause mild stinging, burning, or drowsiness, as well as a mild itching, redness, or irritation of the eyes. Slow or irregular heartbeats, rapid heartbeats or fluttering in the chest, shallow breathing that makes you feel like you might pass out, intense swelling, redness, or discomfort in or around the eye, eye pain or increased watering, or numbness or tingling in the hands or feet are all symptoms to watch out for.


Before combining Combigan with a sedative, narcotic pain reliever, muscle relaxant, or medication for anxiety, depression, or seizures, consult your doctor. Combigan drug interactions (more detail) More information on Combigan (brimonidine / timolol ophthalmic) Price & coupons Generic availability In Spanish FDA approval history Patient resources Advanced Reading Professional resources Prescribing Information Related treatment guides Glaucoma/Intraocular Hypertension Glaucoma Glaucoma/Intraocular Hypertension In this medication guide, not all potential interactions are covered. Combigan may interact with other medications, including over-the-counter drugs, prescription drugs, vitamins, and herbal remedies. Combigan Product Label References Tell your doctor about all of your current medications, as well as any that you start using or stop using while taking Combigan, in particular: This is not a comprehensive list. These effects may be exacerbated if this medication is taken with other medications that cause drowsiness or slow breathing. Digoxin, digitalis, reserpine, antidepressants such as amitriptyline, bupropion, clomipramine, desipramine, doxepin, duloxetine, fluoxetine, imipramine, nortriptyline, and paroxetine, MAO inhibitors such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylc


Although Combigan had minimal effect on the blood pressure of most patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease. Combigan contains benzalkonium chloride which may be absorbed by soft contact lenses. Combigan may worsen diseases associated with weak blood flow. Patients who have Raynaud's phenomenon, orthostatic hypotension, cerebral or coronary insufficiency, or both, should use Combigan with caution. If you experience any of the following symptoms, contact your doctor right away and stop taking Combigan: sudden difficulty breathing, sudden extreme fatigue, swelling of the extremities, or low blood pressure during surgery. Until you know how Combigan affects you, avoid operating heavy machinery or driving. You should not use Combigan if you have any of the following conditions: severe chronic obstructive pulmonary disease, sinus bradycardia, second- or third-degree atrioventricular block, heart failure, or a history of bronchial asthma. Eye infections. Eyedrop containers can become inadvertently contaminated by patients who not use eye drops properly or do not store them in a clean area. Consult your doctor about how to correctly recognize symptoms of low blood pressure while taking Combigan if you have diabetes and take insulin or other medications to control your blood sugar. If you have hyperthyroidism, talk to your doctor about the best way to recognize thyroid emergency symptoms while taking Combigan. concealing the hyperthyroidism symptoms. concealment of low blood sugar symptoms. Combigan can make you feel drowsy, sleepy, and dizzy due to muscle weakness. 15 minutes after administering Combigan, replace your contact lenses. Before taking Combigan, take out your contact lenses. Combigan is known to cause serious side effects, such as the following: worsening of conditions involving poor blood flow. severe cardiac reactions, such as heart failure. severe asthmatic patients' bronchospasms and other respiratory reactions. If you have trouble breathing, stop taking Combigan and notify your doctor right away. There have been reports of bacterial eye infections associated with the use of eye drop products. heart disease getting worse. In order to avoid complications during major surgery, your doctor may advise stopping Combigan.

Is Combigan the same as timolol?

Combigan is a fixed combination of brimonidine, an alpha-2 adrenergic agonist, and timolol, a beta blocker. It is used twice daily to reduce intraocular pressure. Both agents act complementarily to reduce IOP by suppressing aqueous production via different pathways.

How long can you use Combigan eye drops?

Throw out any remaining solution after four weeks from the date of opening. Eye drops contain a preservative which helps prevent germs growing in the solution for the first four weeks after opening the bottle.

Is there a cheaper version of Combigan?

There's currently no generic form of Combigan. However, there's a generic form of Lumigan called bimatoprost. Brand-name medications usually cost more than generics.

Is there a generic version of Combigan?

Apotex Corporation has launched the authorized generic version of Combigan® (Brimonidine Timolol OPSO 0.2%/0.5%) in the United States. Brimonidine Timolol is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

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EssDub Sep 27, 2016, 10:51:45 AM

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Chris L May 5, 2013, 10:40:00 AM

If it is almost time for your next dose, only take one dose. Hair loss is not a reported side effect of Simbrinza. Exercise caution if you are taking any antihypertensives or cardiac glycosides. Related Drugs Alphagan Azarga Azopt Combigan Lumigan Travatan Z Vyzulta Xalatan References: • • Simbrinza.

Saif Mohammed Jun 14, 2016, 3:56:06 PM

Some people complain about depression, burning sensation in eyelids, teary eyes, foreign body sensation, etc. For patients having Glaucoma, the doctors suggest Generic Combigan Eye Drop. If the eye drop doesn't suit you it can cause some allergies, conjunctival folliculosis, Conjunctival hyperemia, etc. The Combigan Eye drop comes to your mouth after a certain time and it can cause oral dryness.

yetAnotherStudent Jan 31, 2019, 10:27:36 AM

Combigan sold in the U.S. is manufactured in the U.S. Combigan (brimonidine and timolol) is prescribed for the treatment of glaucoma and lowering pressure in the eyes. It works by reducing the amount of fluid in the eyes. You can save money on Combigan eye drops 0.2/0.5 % using online pharmacies. Combigan is available in the U.S. and at accredited international online pharmacies.

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