There could be negative effects from colchicine. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Colchicine may reduce male fertility. If you experience any of the following symptoms, stop taking colchicine right away and call your doctor. Nausea, vomiting, diarrhea, stomach cramps or pain, muscle pain or weakness, numbness or tingling in the fingers or toes, unusual bruising or bleeding, sore throat, fever, chills, and other signs of infection The dangers of taking colchicine should be discussed with your doctor. Tell your doctor if any of the following symptoms are severe or do not go away : nausea vomiting diarrhea stomach cramps or pain muscle pain or weakness numbness or tingling in the fingers or toes unusual bruising or bleeding sore throat, fever, chills, and other signs of infection weakness or tiredness paleness or grayness of the lips, tongue, or palms Some side effects can be serious.
For more information, consult your physician or pharmacist. Especially tell your doctor if you are taking: atazanavir sulfate (Reyataz) clarithromycin (Biaxin) cyclosporine (Neoral, Gengraf, Sandimmune) darunavir (Prezista) fosamprenavir (Lexiva) with ritonavir fosamprenavir (Lexiva) indinavir (Crixivan) itraconazole (Sporanox) ketoconazole (Nizoral) Iopinavir/ritonavir (Kaletra) nefazodone (Serzone) nelfinavir mesylate(Viracept) ritonavir (Norvir) saquinavir mesylate (Invirase) telithromycin (Ketek) tipranavir (Aptivus) Do not start a new medicine without talking to your doctor. You should let your doctor know about all of your medications, even those that you may only be using temporarily, like antibiotics. This is not a complete list of colchicine drug interactions.
Ask your doctor or pharmacist or check the medication guide for a list of ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional products, and herbal supplements you are taking, have taken within the past 14 days, or plan to take. Be sure to mention any of the following: aprepitant (Emend); cholesterol-lowering drugs (statins) such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravacho); antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin), If you have an allergy to any of the ingredients in colchicine tablets or solution, talk to your doctor and pharmacist before taking colchicine. Call your doctor if you get pregnant while taking colchicine. Many other medications may also interact with colchicine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have or have ever had kidneyor liver disease. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Inform your doctor if you are pregnant, intend to become pregnant, or are breastfeeding, as these conditions may make it necessary for them to advise you against taking colchicine.