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Colchicine
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colchicine brand name

Antigout anti-inflammatory agent P-glycoprotein use or the use of potent CYP3A4 inhibitors together with concurrent renal or hepatic dysfunction raises the risk of toxicity. used as the main treatment and preventative measure for acute gout as well as for familial Mediterranean fever

Other names for this medication:
Colcrys, Gloperba, Mitigare

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Etoricoxib, Motrin, Piroxicam, Naprosyn, Cyclosporine, Feldene, Arcoxia, Naproxen, Neoral, Indocin, Zyloprim

Description

Monosodium urate crystals from hyperuric body fluids that are deposited in the joint tissue are thought to cause an acute gout attack by triggering an inflammatory response, which becomes worse as more crystals build up. As a result lactic acid and proinflammatory enzymes are released which cause inflammation with severe pain, redness, and swelling of the affected joint. Colchicine is transformed into 2-O- and 3-O-demethylcolchicine by the enzyme CYP3A4. Regardless of concentration, colchicine only binds to albumin and other minor proteins in serum (39 5%). Colchicine directly reduces the production of lactic acid while also preventing leukocytes from phagocytosing uric acid. Orally administered colchicine is absorbed, with a single dose given while fasting resulting in a mean Cmax of 2.5 ng/mL (range 1.1 to 4.4 ng/mL) in 1 to 2 hours. The mean elimination half-life after multiple oral doses (0.6 mg twice daily) is 26.6 to 31.2 hours. A local pH decrease that is favored by lactic acid makes uric acid deposition more effective. In an effort to phagocytose the urate crystals, leukocytes move to the locations where they have been deposited. Plasma levels of these metabolites are minimal (less than 5% of parent drug). Between 5 and 8 L/kg is the average apparent volume of distribution. As a result, the cycle of urate crystal deposition and inflammatory response that sustains an acute gout attack is broken.

Dosage

If your symptoms don't go away or worsen, call your doctor right away. With or without food, colchicine can be taken. There are different colchicine dosages for gout and Mediterranean fever. Detailed instructions on Colchicine dosage Never buy colchicine online or from suppliers outside of the United States. Even if you feel fine, do not stop using colchicine unless your doctor instructs you to. Take this medication only as directed and never in excess of that. Follow all directions on your prescription label. Pay attention to your doctor's advice. You might need frequent medical exams if you take this medication for a prolonged period of time. When not in use, keep the bottle firmly shut. Away from moisture, heat, and light, store at room temperature. It may be less effective the longer you wait to begin taking the medication. Colchicine should be taken as soon as a gout attack is noticed for best results. Using this medication improperly or without the advice of a doctor can result in serious side effects or death. If your gout pain persists an hour after taking the first dose of colchicine, you might need to take a second, smaller dose. Depending on why you are taking this medication, you will receive a different dose.

Missed dose

To make up for a missed dose, don't take more medication. If it is almost time for your next scheduled dose, skip the missed dose. The missed dose should be taken as soon as you remember.

Overdose

However, if overdose is suspected, seek emergency medical attention. It is unlikely that an overdose will happen if colchicine is given by a medical professional in a hospital setting. Call your doctor, your local poison control center, or get immediate medical help if you take too much colchicine.

Storage

Keep the medication away from children. Protect from light and moisture. Store at or below 30 °C.

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Side effects

There could be negative effects from colchicine. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Colchicine may reduce male fertility. If you experience any of the following symptoms, stop taking colchicine right away and call your doctor. Nausea, vomiting, diarrhea, stomach cramps or pain, muscle pain or weakness, numbness or tingling in the fingers or toes, unusual bruising or bleeding, sore throat, fever, chills, and other signs of infection The dangers of taking colchicine should be discussed with your doctor. Tell your doctor if any of the following symptoms are severe or do not go away : nausea vomiting diarrhea stomach cramps or pain muscle pain or weakness numbness or tingling in the fingers or toes unusual bruising or bleeding sore throat, fever, chills, and other signs of infection weakness or tiredness paleness or grayness of the lips, tongue, or palms Some side effects can be serious.

Interactions

For more information, consult your physician or pharmacist. Especially tell your doctor if you are taking: atazanavir sulfate (Reyataz) clarithromycin (Biaxin) cyclosporine (Neoral, Gengraf, Sandimmune) darunavir (Prezista) fosamprenavir (Lexiva) with ritonavir fosamprenavir (Lexiva) indinavir (Crixivan) itraconazole (Sporanox) ketoconazole (Nizoral) Iopinavir/ritonavir (Kaletra) nefazodone (Serzone) nelfinavir mesylate(Viracept) ritonavir (Norvir) saquinavir mesylate (Invirase) telithromycin (Ketek) tipranavir (Aptivus) Do not start a new medicine without talking to your doctor. You should let your doctor know about all of your medications, even those that you may only be using temporarily, like antibiotics. This is not a complete list of colchicine drug interactions.

Contraindications

Ask your doctor or pharmacist or check the medication guide for a list of ingredients. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional products, and herbal supplements you are taking, have taken within the past 14 days, or plan to take. Be sure to mention any of the following: aprepitant (Emend); cholesterol-lowering drugs (statins) such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravacho); antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin), If you have an allergy to any of the ingredients in colchicine tablets or solution, talk to your doctor and pharmacist before taking colchicine. Call your doctor if you get pregnant while taking colchicine. Many other medications may also interact with colchicine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. tell your doctor if you have or have ever had kidneyor liver disease. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Inform your doctor if you are pregnant, intend to become pregnant, or are breastfeeding, as these conditions may make it necessary for them to advise you against taking colchicine.

Is Mitigare the same as colchicine?

The FDA approved Mitigare® (Colchicine) 0.6 mg Capsules, the first and only other branded colchicine product for prevention of gout flares in adults.

Why was colchicine taken off the market?

However, Colcrys (colchicine, Takeda Pharmaceuticals) — the first FDA-regulated product — entered the market in 2009 at $5 per pill and received exclusivity to treat gout for 3 years. This caused the other unapproved formulation of colchicine to be ordered off the market.

Is Mitigare a generic for colchicine?

Mitigare® (colchicine) 0.6 mg Capsules, and its authorized generic, colchicine 0.6 mg capsules, are a distinctive two-tone blue color. This pop of color may help adult patients distinguish these capsules from other medications they take.

Why is colchicine toxic?

As a mitotic inhibitor, colchicine's toxic effects are first seen in the rapidly proliferating cells of the gastrointestinal epithelium. Within two to twelve hours of ingestion or administration of IV colchicine, nausea, abdominal pain, vomiting and diarrhea resulting in significant fluid losses may be seen.

Which is better for gout colchicine or indomethacin?

Indocin (indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects. Colcrys (colchicine) treats and stops sudden gout attacks. It can be used to prevent gout when people are first starting on allopurinol.

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Testimonials
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cdoch Nov 28, 2020, 1:20:35 AM

Getting answers to your questions If you have questions about the True Blue Savings card, click here. Patient Brochure— Learn more about preventing gout flares and Mitigare. Only eligible patients pay as little as $0 for the first 30 days. *Please see complete eligibility Terms and Conditions available at Mitigare.com. Maximum savings of $65 on the first fill and $50 on refills.

Ehsan Hasin Aug 12, 2017, 8:54:59 PM

Is colchicine beneficial in the management of coronary artery disease? However, colchicine had no effect on the risk of death, either from heart disease or other causes. It is not clear if colchicine reduces the risk of heart attack, stroke, or death in patients with CAD.

Ian Khel Hidayat Aug 10, 2021, 2:22:31 AM

Please see the full Prescribing Information and Medication Guide for Mitigare for complete product details. Talk with your doctor about taking Colchicine with ULT If you are taking ULT and still suffer with gout flares, talk with your doctor. Neuromuscular toxicity and rhabdomyolysis may occur with chronic treatment with colchicine in therapeutic doses, especially in combination with other drugs known to cause this effect. For a full list of resources and their attributing links, see below.

nizam abdullah Oct 14, 2017, 11:27:41 AM

This strategy was devised to help people with gout achieve a uric acid level of less than 6 mg/dL of blood. These are just some of the reasons why it is so important to gain control of the disease early on—before it becomes chronic. NOTE: This article was not written by a medical professional and is not intended to substitute for the guidance of a physician. Many people with gout take ULT and colchicine or another anti-inflammatory medicine as part of their gout flare prevention treatment program. Talk with your doctor If you are taking ULT and still suffering with gout flares, talk with your doctor.

BlitzkriegBlue May 18, 2014, 3:30:18 PM

If you have kidney or liver disease, your doctor may prescribe a lower dose. In which case, skip the missed dose and take the next one at the usual time. Your doctor will probably recommend taking this medicine long-term. Follow your doctor's instructions about how many tablets to take, and how many times a day. You will also have regular blood and urine tests.

AARON KILI Sep 5, 2021, 8:51:40 PM

Fast Facts on the Mitigare (Colchicine) True Blue Savings Card The Mitigare® True Blue Savings Card helps qualified patients save on their colchicine therapy. With the Mitigare® True Blue Savings Card, eligible patients can receive Mitigare®(colchicine) 0.6 mg Capsules or Authorized Read more...

Brad Dwight Hill Jun 18, 2012, 1:46:28 PM

US Brand Name Descriptions Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). Colchicine is not an ordinary pain reliever and will not relieve most kinds of pain. Most people take small amounts of it regularly for a long time (months or even years) to prevent severe attacks or other problems caused by inflammation.

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