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clonidine drug interaction

If you get out of a lying position too quickly while taking clonidine, you could experience lightheadedness, dizziness, and fainting. High blood pressure is treated with clonidine. When taking clonidine for the first time, this happens more frequently.

Other names for this medication:
Catapres, Kapvay, Catapres-TTS, Catapres-Tts-1, Duraclon

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Beloc, Combipres, Valsartan, Toprol, Norvasc, Carvedilol, Minipress, Aceon, Benicar, Coversyl, Tenoretic, Losartan, Calan, Bystolic, Zytanix, Hyzaar, Bisoprolol, Telmisartan, Micardis


Alpha-2 adrenoceptors are antagonized by clonidine, which has effects like lowering blood pressure, sedation, and hyperpolarization of nerves. Given twice daily, it has a long duration of action, and the therapeutic range is between 0.1mg and 2.4mg per day.


Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Children under 6 years old: Your doctor must determine the use and dosage. Your doctor must determine the use and dosage for children. Clonidine extended-release tablets works differently than clonidine immediate-release tablets. A patient information leaflet is typically included with clonidine. The functionality of various brands might vary. Do not chew, cut, or crush it. If your doctor doesn't instruct you to, don't switch from extended-release to immediate-release medication. Use medication only as prescribed by your doctor, and never take it more frequently. Observe your doctor's instructions or the instructions on the product's label. Teenagers and kids aged 6 and older—At first, 0.1 milligram (mg) once daily, given at bedtime, for attention deficit hyperactivity disorder (ADHD) oral dosage form (extended-release tablets). Adults—At first, 0.17 milligram (mg) or 2 milliliter (mL) once a day, given at bedtime, for high blood pressure in the oral dosage form (extended-release suspension). Adults: Start with 0.17 milligram (mg) given once daily at bedtime in the oral dosage form (extended-release tablets). Adults should take 0.1 milligram (mg) of the oral dosage form (tablets) twice daily, in the morning and at bedtime. For patients taking the prolonged-release oral suspension: Utilize the dosage that your doctor has advised. If high blood pressure is not treated, it can result in serious issues like heart failure, blood vessel disease, stroke, or kidney disease. Ask your doctor any questions you may have. Unless your doctor instructs you to, do not alter your dose if it differs from the recommended one. Treatment for high blood pressure may also involve diet changes, especially ones that reduce your intake of foods high in sodium (salt), and weight loss in addition to the use of clonidine. In fact, many may feel normal. Place the adapter inside the bottle's neck. Turn the bottle upside down while inserting the syringe tip into the adapter. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Many patients who have high blood pressure will not notice any signs of the problem. Put the medication right in your mouth. Before using clonidine, make sure you have carefully read and comprehended them. Remember that clonidine will not cure your high blood pressure but it does help control it. Each time you use the bottle, shake it vigorously for 5 to 10 seconds. Completely swallow the extended-release tablet. The amount of medicine that you take depends on the strength of the medicine. For various patients, there will be a different clonidine dose. Only the typical clonidine doses are listed in the information below. The typical dose ranges from 0.17 mg (2 mL) to 0.52 mg (6 mL) daily. The usual dose is 0.17 to 0.52 mg per day. The typical dose is divided into two doses of 0.2 mg to 0.6 mg per day. Thus, if you want to lower your blood pressure and keep it down, you must continue to use it as prescribed. Use only the brand of clonidine that your doctor recommended. You may have to take high blood pressure medicine for the rest of your life. Whether you eat or not, you can take the tablet. Before making dietary changes, consult with your doctor. Your doctor may adjust your dose as needed. As required, your doctor will raise your dosage. Your physician will advise you on the frequency and dosage of clonidine use. Which of these is most crucial for you will be revealed by your doctor. Your dose may need to be changed several times in order to find out what works best for you.

Missed dose

Do not double doses. On the other hand, skip the missed dose and resume your regular dosing schedule if it is almost time for your next dose. When taking clonidine extended-release tablets, skip the dose you missed and continue taking the medication as prescribed. Take clonidine as soon as you remember if you miss a dose. Immediately consult your doctor if you miss more than one dose of clonidine tablets. Your blood pressure may rise to an extremely high level and result in serious side effects if your body is depleted of clonidine for an extended period of time.


However, if overdose is suspected, seek emergency medical attention. It is unlikely that an overdose will happen if clonidine is given by a healthcare professional in a medical setting. Call your doctor, your local poison control center, or get immediate medical help if you take too much clonidine.


You should not, however, dispose of this medication in the toilet. Instead, using a medication take-back program is the best way to get rid of your medication. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Keep this medication tightly closed in its original container away from the reach of children. If you do not have access to a take-back program, you can find more information at the FDA's Safe Disposal of Medicines website ( Store it at room temperature, away from sources of extreme heat, and dry (not in the bathroom). To find out about take-back programs in your neighborhood, speak with your pharmacist or get in touch with your city's waste/recycling department. Always lock safety caps and put medication in a secure location right away that is up and away and out of young children's sight and reach to prevent poisoning. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Side effects

A medicine may also have some unintended side effects in addition to the effects that are required. Even though not all of these side effects are likely to happen, if they do, medical attention may be required. Check with your doctor immediately if any of the following side effects occur: Less frequent Mental depression swelling of the feet and lower legs Rare


To learn more, consult your physician or pharmacist. Tell your doctor right away if you take any of the following medications: digoxin (Lanoxin), calcium channel blockers such as verapamil (Calan), diltiazem (Cardizem), or amlodipine (Norvasc), beta blockers such as carvedilol (Coreg), or metoprolol (Lopressor), alcohol, barbiturates, such as phenobarbital, or tricyclic antidepress Inform your doctor about all of the medications you take, including any prescription and over-the-counter drugs, vitamins, and herbal supplements.


Inform your doctor and pharmacist about all prescription and nonprescription drugs, vitamins, dietary supplements, and herbal products you are currently taking or plan to take. Before taking clonidine, tell your doctor and pharmacist if you are allergic to clonidine, any of its ingredients, clonidine patches, or any other medications.

What class is clonidine?

Clonidine belongs to the class of medicines called antihypertensives. It works in the brain to change some of the nerve impulses. As a result, the blood vessels relax and blood passes through them more easily, which lowers blood pressure.

Is clonidine an alpha or beta-blocker?

Metoprolol and clonidine belong to different drug classes. Metoprolol is a beta-blocker (beta-adrenergic blocking agent) and clonidine is an alpha-2 adrenergic agonist (central alpha agonist). Side effects of metoprolol and clonidine that are similar include constipation, fatigue/tiredness, or impotence.

Can clonidine be sublingual?

Sublingual clonidine may be a useful addition to the treatment of the hypertensive patient because of its apparent effectiveness, simplicity, and safety.

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kajal chaudhri Nov 8, 2018, 12:33:48 PM

Read more Clonidine (Clonidine transdermal system) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials. It is available in strength of 0.1 mg/d per ml. Disclaimer GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Clonidine (Clonidine transdermal system) which is also known as Clonidine transdermal system and Manufactured by Actavis Pharma, Inc..

Ghazali Shacklebolt Jun 6, 2020, 10:42:34 AM

Examples of catecholamine-depleting drugs include: Clonidine: If you’re taking clonidine with nebivolol but need to stop taking it because your blood pressure is getting too low, your doctor will first stop your nebivolol treatment for several days before your clonidine treatment is stopped. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. This can be harmful or prevent the drug from working well.

shakeIt Mar 27, 2010, 1:13:25 AM

Lastly, they are ideal for people who cannot take stimulant ADHD treatments due to health reasons such as heart conditions. One of the medications that doctors prescribe for ADHD is clonidine. It may not be effective for ADHD with inattentive presentations and symptoms. It also affects the composition and production of breast milk.

sqrt Jun 18, 2020, 1:39:14 AM

As a result, many patients form a dependence on it, and some patients are afraid of the withdrawal symptoms upon discontinuing Catapres use. This medicine is prescribed for various health conditions and disorders such as ADHD, which helps control hyperactivity and impulsivity. Those addicted to opiates have the greatest potential for developing a Clonidine addiction. A Clonidine patch is applied on the upper arm or chest once a week. 1997;3(2):105-. Schindler EA, Tirado-Morales DJ, Kushon D. Clonidine abuse in a methadone-maintained, clonazepam-abusing patient.

Washington Guilhardes May 22, 2022, 10:43:53 PM

Consult your doctor or pharmacist if you have questions about your dosing schedule.The dosage is based on your medical condition and response to treatment.If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 2 hours before or at least 4 hours after these medications.Use this medication regularly to get the most benefit from it. Report any new or worsening symptoms immediately.When used for a long time, this medication may not work as well and may require different dosing or an additional medication. To prevent any reactions while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Chlorthalidone is a "water pill" (diuretic) and causes your body to get rid of extra salt and water. HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily.

Openmindead Oct 6, 2022, 1:55:12 AM

It is stable in light, air, and heat and does not exhibit polymorphism. Gabapentin (cyclohexaneacetic acid, Neurontin, CHNO, MW 171.24) occurs as a white to off-white, crystalline solid that is freely soluble in water and in alkaline and acidic solutions. It is classified as a centrally acting alpha 2 adrenergic agonist and imidazoline receptor agonist and has been in clinical use since 1966. The content is not intended to be a substitute for professional advice. Ethoxydiglycol is nonirritating and is used as a solvent, solubilizer, and cosurfactant.

Alex Peterson May 29, 2014, 8:01:30 PM

Risk Summary Prolonged experience with clonidine in pregnant women over several decades, based on published literature, including controlled trials, a retrospective cohort study and case reports, have not identified a drug associated risk of major birth defects, miscarriage, and adverse maternal or fetal outcomes. Increases in resorptions were observed in both rats and mice at 500 mcg/kg/day (10 and 5 times the MRHD in rats and mice, respectively) or higher when the animals were treated on gestation days 1 to 14; 500 mcg/kg/day was the lowest dose employed in this study. No developmental effects were seen in rabbits administered oral clonidine hydrochloride during organogenesis at doses up to 3 times the MRHD (see Data). • Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ADHD medications, including clonidine hydrochloride, during pregnancy. In animal embryofetal studies, increased resorptions were seen in rats and mice administered oral clonidine hydrochloride from implantation through organogenesis at 10 and 5 times, respectively, the maximum recommended human dose (MRHD) given to adolescents on a mg/m2 basis.

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